HitPredict

Interactor 1: CTBP2 (P56545)
C-terminal-binding protein 2 (CtBP2)
Gene: CTBP2

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	35271311, 30585266, 36414381, 19754958
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0045892 - negative regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 445 Hs			1 488
+	Hs
		881167 CTBP2_HUMAN (1-445): 0: 604: 100.00		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1032538 CTBP1_HUMAN (20-445): 0: 520: 80.99		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Mm
		292164 CTBP1_MOUSE (20-445): 0: 515: 80.56		HDAC2_MOUSE (1-488): 0: 704: 99.39
+	Hs
		1032389 CTBP1_HUMAN (20-445): 0: 520: 80.99		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		177284 CTBP1_HUMAN (20-445): 0: 520: 80.99		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Hs
		197419 SERA_HUMAN (35-410): 8.39e-125: 374: 27.32		HDAC6_HUMAN (11-363): 6.94e-102: 332: 24.04