HitPredict

Interactor 1: BCAR1 (P56945)
Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas)
Gene: BCAR1

Interactor 2: PTN12 (Q05209)
Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1)
Gene: PTPN12

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.727

Property	Details
Experiments	12714323, 9285683, 9748319, 27880917, 8887669
Identification Methods	affinity chromatography technology, pull down, proximity labelling technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0017124 - SH3 domain binding
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 780
+	Mm
		728829 BCAR1_MOUSE (1-870): 1.73e-102: 339: 88.67		PTN12_MOUSE (1-780): 0: 560: 83.10
+	Hs
		983485 CASL_HUMAN (1-868): 1.02e-91: 309: 35.96		PTN12_HUMAN (1-780): 0: 586: 100.00
+	Hs
		573636 BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00		PTN1_HUMAN (27-409): 1.5e-127: 389: 24.46
+	Hs
		983518 CASS4_HUMAN (4-865): 6.37e-38: 154: 19.91		PTN12_HUMAN (1-780): 0: 586: 100.00
+	Hs
		882258 BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00		PTN11_HUMAN (7-351): 1.65e-124: 387: 31.48
+	Rn
		783508 BCAR1_RAT (2-870): 4.08e-103: 343: 89.12		PTN11_RAT (7-351): 1.11e-123: 385: 31.48
+	Hs
		983476 ACK1_HUMAN (9-499): 2.55e-30: 131: 15.35		PTN12_HUMAN (1-780): 0: 586: 100.00
+	Hs
		985955 CASL_HUMAN (1-868): 1.02e-91: 309: 35.96		PTN11_HUMAN (7-351): 1.65e-124: 387: 31.48
+	Hs
		199511 EFS_HUMAN (4-429): 4.35e-14: 78: 22.56		PTN12_HUMAN (1-780): 0: 586: 100.00
+	Hs
		441194 ACK1_HUMAN (9-499): 2.55e-30: 131: 15.35		PTPRC_HUMAN (13-678): 1.57e-143: 456: 19.30
+	Dm
		561764 Q9VLS7_DROME (65-706): 2.75e-10: 66.5: 9.08		PTP69_DROME (7-298): 8.96e-74: 264: 26.25
+	Hs
		992570 ACK1_HUMAN (9-499): 2.55e-30: 131: 15.35		PTPRJ_HUMAN (49-297): 6.23e-46: 179: 39.13
+	Dm
		729777 Q9VLS7_DROME (65-706): 2.75e-10: 66.5: 9.08		PTP10_DROME (58-295): 6.75e-42: 167: 36.98