Protein: TFS2
Transcription elongation factor S-II (DNA strand transfer protein alpha) (STP-alpha) (DNA strand transferase 1) (Pyrimidine pathway regulatory protein 2)

Gene: TFS2, DST1
Organism: Saccharomyces cerevisiae S288C
Interactions: 62
UniProt ID: P07273

Gene Ontology (top 5):
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000993 - RNA polymerase II complex binding
GO:0001139 - RNA polymerase II complex recruiting activity
GO:0001193 - maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

401820

RPB1
DNA-directed RNA polymerase II subunit RPB1

8

7

Small-scale

0.967

High

454556

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

2

2

High-throughput

0.789

High

454554

RPB3
DNA-directed RNA polymerase II subunit RPB3

5

8

Small-scale

0.709

High

454561

RPB9
DNA-directed RNA polymerase II subunit RPB9

3

5

High-throughput

0.667

High

454550

TFS2
Transcription elongation factor S-II

1

3

High-throughput

0.665

High

454571

LEO1
RNA polymerase-associated protein LEO1

2

2

Small-scale

0.602

High

454573

SPT8
SAGA complex subunit SPT8

2

0

Small-scale

0.593

High

454551

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.536

High

454552

SSB1
Ribosome-associated molecular chaperone SSB1

1

2

High-throughput

0.536

High

454595

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.536

High

454572

RPB11
DNA-directed RNA polymerase II subunit RPB11

1

5

High-throughput

0.515

High

454584

NMD5
Nonsense-mediated mRNA decay protein 5

1

1

Small-scale

0.515

High

448602

SNF1
Carbon catabolite-derepressing protein kinase

1

2

High-throughput

0.501

High

454553

GCN2
eIF-2-alpha kinase GCN2

1

1

High-throughput

0.501

High

454570

PAF1
RNA polymerase II-associated protein 1

1

1

Small-scale

0.501

High

454604

HAA1
Transcriptional activator HAA1

1

0

High-throughput

0.493

High

454592

BRE5
UBP3-associated protein BRE5

1

1

High-throughput

0.489

High

454602

SMT3
Ubiquitin-like protein SMT3

1

2

High-throughput

0.481

High

440997

KAPA
cAMP-dependent protein kinase type 1

1

0

High-throughput

0.480

High

454558

NOT1
General negative regulator of transcription subunit 1

1

0

Small-scale

0.480

High

454568

NOT4
General negative regulator of transcription subunit 4

1

0

Small-scale

0.480

High

454575

POP2
Poly(A) ribonuclease POP2

1

0

Small-scale

0.480

High

454555

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

1

Small-scale

0.479

High

454559

CDC48
Cell division control protein 48

1

2

High-throughput

0.479

High

454560

SPT5
Transcription elongation factor SPT5

1

1

High-throughput

0.479

High

454563

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.479

High

454564

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

3

High-throughput

0.479

High

454565

HOG1
Mitogen-activated protein kinase HOG1

1

3

Small-scale

0.479

High

454569

SPT7
SAGA complex subunit SPT7

1

1

Small-scale

0.479

High

454576

SSN3
Meiotic mRNA stability protein kinase SSN3

1

7

Small-scale

0.479

High

454583

SERB
Phosphoserine phosphatase

1

1

High-throughput

0.479

High

454596

GCN5
Histone acetyltransferase GCN5

1

4

Small-scale

0.479

High

454597

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.479

High

454598

POB3
FACT complex subunit POB3

1

2

High-throughput

0.479

High

454562

SBA1
Co-chaperone protein SBA1

1

0

Small-scale

0.460

High

454600

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

454601

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

392020

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.445

High

454557

SIS1
Protein SIS1

1

1

High-throughput

0.445

High

454566

HSP7F
Heat shock protein homolog SSE1

1

4

High-throughput

0.445

High

454578

XDJ1
DnaJ protein homolog XDJ1

1

3

High-throughput

0.445

High

454581

SSB2
Ribosome-associated molecular chaperone SSB2

1

2

High-throughput

0.445

High

454582

T2FB
Transcription initiation factor IIF subunit beta

1

3

Small-scale

0.445

High

454594

APJ1
J domain-containing protein APJ1

1

3

High-throughput

0.445

High

454585

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.426

High

454593

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.426

High

454589

PFD3
Prefoldin subunit 3

1

1

High-throughput

0.407

High

454574

SSN2
Mediator of RNA polymerase II transcription subunit 13

2

0

Small-scale

0.323

High

454567

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.279

Low

454580

DPO5
rDNA transcriptional regulator POL5

1

0

High-throughput

0.269

Low

427518

RLA1
Large ribosomal subunit protein P1A

1

0

High-throughput

0.249

Low

434477

RL22A
Large ribosomal subunit protein eL22A

1

0

High-throughput

0.249

Low

454579

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

454586

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.249

Low

454588

ASK10
Activator of SKN7 protein 10

1

0

Small-scale

0.249

Low

454590

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

0

High-throughput

0.249

Low

454591

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.249

Low

454599

ATG26
Sterol 3-beta-glucosyltransferase

1

0

High-throughput

0.249

Low

454577

TCPG
T-complex protein 1 subunit gamma

1

0

High-throughput

0.232

Low

454587

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.232

Low

454603

HSP42
Heat shock protein 42

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025