HitPredict

Interactor 1: BCAR1 (P56945)
Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas)
Gene: BCAR1

Interactor 2: ACK1 (Q07912)
Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2)
Gene: TNK2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	36736316, 17038317
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 1038
+	Hs
		337411 BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00		ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03
+	Hs
		882256 BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00		FAK1_HUMAN (6-692): 3.3e-131: 425: 21.01
+	Hs
		337474 CASL_HUMAN (1-868): 1.02e-91: 309: 35.96		ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03
+	Rn
		192646 BCAR1_RAT (2-870): 4.08e-103: 343: 89.12		FAK1_RAT (6-692): 3.87e-131: 425: 21.36
+	Mm
		710139 BCAR1_MOUSE (1-870): 1.73e-102: 339: 88.67		FAK1_MOUSE (6-692): 1.85e-131: 426: 21.28
+	Hs
		433301 BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00		YES_HUMAN (1-400): 1.3e-128: 403: 29.93
+	Hs
		522874 BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00		SRC_HUMAN (1-400): 3.99e-127: 399: 31.42
+	Hs
		412110 BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00		FYN_HUMAN (1-400): 2.52e-126: 397: 30.18
+	Hs
		411655 BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00		LCK_HUMAN (1-398): 8.72e-125: 391: 30.08
+	Hs
		882292 BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00		FAK2_HUMAN (49-624): 1.48e-117: 387: 26.22
+	Rn
		1144044 BCAR1_RAT (2-870): 4.08e-103: 343: 89.12		FYN_RAT (1-400): 7.56e-126: 395: 30.18
+	Rn
		1144372 BCAR1_RAT (2-870): 4.08e-103: 343: 89.12		SRC_RAT (1-400): 8.14e-126: 395: 31.17
+	Mm
		763397 BCAR1_MOUSE (1-870): 1.73e-102: 339: 88.67		FYN_MOUSE (1-400): 4.06e-126: 396: 30.18
+	Mm
		403441 BCAR1_MOUSE (1-870): 1.73e-102: 339: 88.67		SRC_MOUSE (1-400): 4.79e-125: 393: 31.17
+	Hs
		433668 BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00		LYN_HUMAN (92-388): 4.52e-112: 358: 36.79
+	Hs
		442799 BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00		HCK_HUMAN (76-388): 8.7e-112: 358: 34.40
+	Hs
		412193 CASL_HUMAN (1-868): 1.02e-91: 309: 35.96		FYN_HUMAN (1-400): 2.52e-126: 397: 30.18
+	Hs
		411721 CASL_HUMAN (1-868): 1.02e-91: 309: 35.96		LCK_HUMAN (1-398): 8.72e-125: 391: 30.08
+	Mm
		639448 BCAR1_MOUSE (1-870): 1.73e-102: 339: 88.67		LYN_MOUSE (92-388): 4.67e-112: 358: 37.46
+	Hs
		338201 BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00		EGFR_HUMAN (105-387): 2.98e-55: 211: 39.58