Protein: PREP
Presequence protease, mitochondrial (PreP) (EC 3.4.24.-) (Metalloprotease of 112 kDa) (Pitrilysin metalloproteinase) (Protease M)

Gene: PREP, CYM1
Organism: Saccharomyces cerevisiae S288C
Interactions: 46
UniProt ID: P32898

Gene Ontology (top 5):
GO:0004176 - ATP-dependent peptidase activity
GO:0004222 - metalloendopeptidase activity
GO:0005739 - mitochondrion
GO:0005758 - mitochondrial intermembrane space
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

558597

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

3

12

High-throughput

0.662

High

690655

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

3

3

High-throughput

0.662

High

452981

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

3

0

High-throughput

0.634

High

520808

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

2

8

High-throughput

0.621

High

560332

ODPX
Pyruvate dehydrogenase complex protein X component, mitochondrial

2

9

High-throughput

0.621

High

478043

HSP77
Import motor subunit, mitochondrial

2

6

High-throughput

0.584

High

567955

MDHM
Malate dehydrogenase, mitochondrial

2

3

Small-scale

0.584

High

700040

GRPE
GrpE protein homolog, mitochondrial

2

3

High-throughput

0.571

High

341977

ATPB
ATP synthase subunit beta, mitochondrial

1

8

High-throughput

0.479

High

373227

COX4
Cytochrome c oxidase subunit 4, mitochondrial

1

1

High-throughput

0.479

High

423596

ADH3
Alcohol dehydrogenase 3, mitochondrial

1

1

High-throughput

0.479

High

456739

HEM1
5-aminolevulinate synthase, mitochondrial

1

2

High-throughput

0.479

High

584143

ACON
Aconitate hydratase, mitochondrial

1

1

High-throughput

0.479

High

588012

HSP60
Heat shock protein 60, mitochondrial

1

7

High-throughput

0.479

High

630632

TRX3
Thioredoxin-3, mitochondrial

1

1

High-throughput

0.479

High

630787

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

1

High-throughput

0.479

High

641315

KAD3
GTP:AMP phosphotransferase, mitochondrial

1

2

High-throughput

0.479

High

650213

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

1

1

High-throughput

0.479

High

657042

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

2

High-throughput

0.479

High

660896

IDH1
Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial

1

2

High-throughput

0.479

High

700039

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.479

High

700043

ALDH5
Aldehyde dehydrogenase 5, mitochondrial

1

4

High-throughput

0.479

High

700045

COQ7
5-demethoxyubiquinone hydroxylase, mitochondrial

1

5

High-throughput

0.479

High

700046

ETFB
Probable electron transfer flavoprotein subunit beta

1

2

High-throughput

0.479

High

700048

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

1

4

High-throughput

0.479

High

700052

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

2

High-throughput

0.479

High

700054

ISD11
Protein ISD11

1

4

High-throughput

0.479

High

336718

SODM
Superoxide dismutase [Mn], mitochondrial

1

0

High-throughput

0.458

High

410779

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

High-throughput

0.458

High

427214

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

0

High-throughput

0.458

High

602435

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

0

High-throughput

0.458

High

612933

AIM17
Probable oxidoreductase AIM17

1

0

High-throughput

0.458

High

634992

ILV6
Acetolactate synthase small subunit, mitochondrial

1

0

High-throughput

0.458

High

700042

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

0

High-throughput

0.458

High

700049

GCSP
Glycine dehydrogenase

1

0

High-throughput

0.458

High

700050

GLRX5
Monothiol glutaredoxin-5, mitochondrial

1

0

High-throughput

0.458

High

700038

SC61A
Protein transport protein SEC61

1

1

High-throughput

0.437

High

700051

SCC2
Sister chromatid cohesion protein 2

1

3

High-throughput

0.437

High

510730

SSB1
Ribosome-associated molecular chaperone SSB1

1

7

High-throughput

0.407

High

633075

MAS5
Mitochondrial protein import protein MAS5

1

5

High-throughput

0.407

High

700041

TCPD
T-complex protein 1 subunit delta

1

1

High-throughput

0.407

High

700044

JEM1
DnaJ-like chaperone JEM1

1

3

High-throughput

0.407

High

700047

ERJ5
ER-localized J domain-containing protein 5

1

6

High-throughput

0.407

High

700053

HSP42
Heat shock protein 42

2

0

High-throughput

0.324

High

61567

YP010
UPF0495 protein YPR010C-A

1

0

Small-scale

0.249

Low

498857

RL4A
Large ribosomal subunit protein uL4A

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024