Protein: DIDO1
Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1)

Gene: DIDO1
Organism: Homo sapiens
Interactions: 171
UniProt ID: Q9BTC0

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005819 - spindle
GO:0006351 - DNA-templated transcription

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

655323

SFPQ
Splicing factor, proline- and glutamine-rich

3

20

Small-scale

0.861

High

998751

H31
Histone H3.1

3

20

Small-scale

0.814

High

981056

H2B1C
Histone H2B type 1-C/E/F/G/I

2

20

High-throughput

0.754

High

1162026

H31T
Histone H3.1t

2

20

High-throughput

0.727

High

1061125

SRSF1
Serine/arginine-rich splicing factor 1

1

18

High-throughput

0.698

High

1006667

SRPK2
SRSF protein kinase 2

4

20

High-throughput

0.694

High

478185

SNRPA
U1 small nuclear ribonucleoprotein A

1

14

High-throughput

0.691

High

775287

FUS
RNA-binding protein FUS

1

18

High-throughput

0.691

High

1160272

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

20

High-throughput

0.691

High

1163178

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.691

High

1239656

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

7

High-throughput

0.691

High

1388530

RMXL1
RNA binding motif protein, X-linked-like-1

1

18

High-throughput

0.691

High

1409819

RBM4B
RNA-binding protein 4B

1

12

High-throughput

0.691

High

1413304

H2AJ
Histone H2A.J

1

14

High-throughput

0.691

High

185971

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

3

14

High-throughput

0.667

High

373011

MYC
Myc proto-oncogene protein

3

20

High-throughput

0.640

High

1413336

HCFC2
Host cell factor 2

2

15

High-throughput

0.628

High

905474

HCFC1
Host cell factor 1

2

16

High-throughput

0.621

High

256975

H2B1K
Histone H2B type 1-K

1

20

High-throughput

0.618

High

260385

BRD4
Bromodomain-containing protein 4

1

20

High-throughput

0.618

High

431237

LA
Lupus La protein

1

13

High-throughput

0.618

High

462604

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

13

High-throughput

0.618

High

620556

NUCL
Nucleolin

1

9

Small-scale

0.618

High

754969

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.618

High

1017172

H33
Histone H3.3

1

20

High-throughput

0.618

High

1160058

SRSF7
Serine/arginine-rich splicing factor 7

1

20

Small-scale

0.618

High

1399964

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

18

Small-scale

0.618

High

765843

BMI1
Polycomb complex protein BMI-1

2

20

High-throughput

0.611

High

1410275

KLDC3
Kelch domain-containing protein 3

2

17

High-throughput

0.611

High

558373

XRCC6
X-ray repair cross-complementing protein 6

2

12

High-throughput

0.584

High

589558

RFA2
Replication protein A 32 kDa subunit

2

13

High-throughput

0.584

High

696364

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

11

High-throughput

0.584

High

831335

CCNF
Cyclin-F

2

11

High-throughput

0.584

High

686645

ELAV4
ELAV-like protein 4

1

10

High-throughput

0.575

High

396837

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

132273

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

20

High-throughput

0.541

High

521426

ARAF
Serine/threonine-protein kinase A-Raf

1

14

High-throughput

0.541

High

965851

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

12

High-throughput

0.541

High

1413308

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

20

High-throughput

0.541

High

1209589

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

7

High-throughput

0.536

High

158668

TYB4Y
Thymosin beta-4, Y-chromosomal

1

1

High-throughput

0.536

High

277401

TP4A3
Protein tyrosine phosphatase type IVA 3

1

7

High-throughput

0.536

High

455661

KLK3
Prostate-specific antigen

1

2

High-throughput

0.536

High

480292

RU1C
U1 small nuclear ribonucleoprotein C

1

5

High-throughput

0.536

High

542189

TOP1
DNA topoisomerase 1

1

6

High-throughput

0.536

High

574450

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

6

High-throughput

0.536

High

854265

KI67
Proliferation marker protein Ki-67

1

11

High-throughput

0.536

High

879749

MAPK2
MAP kinase-activated protein kinase 2

1

8

High-throughput

0.536

High

974031

RUXF
Small nuclear ribonucleoprotein F

1

6

High-throughput

0.536

High

1008642

MAP1A
Microtubule-associated protein 1A

1

12

High-throughput

0.536

High

1023609

CYC
Cytochrome c

1

3

High-throughput

0.536

High

1036546

ID2
DNA-binding protein inhibitor ID-2

1

1

High-throughput

0.536

High

1065399

SSRP1
FACT complex subunit SSRP1

1

20

High-throughput

0.536

High

1109372

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

High-throughput

0.536

High

1110552

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

2

High-throughput

0.536

High

1236118

CAN13
Calpain-13

1

2

High-throughput

0.536

High

1368796

EZH1
Histone-lysine N-methyltransferase EZH1

1

20

High-throughput

0.536

High

1413320

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

1

3

High-throughput

0.536

High

1413332

TPX2
Targeting protein for Xklp2

1

8

High-throughput

0.536

High

1413333

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

8

High-throughput

0.536

High

1413335

TNPO3
Transportin-3

1

5

High-throughput

0.536

High

769036

RFA3
Replication protein A 14 kDa subunit

2

10

High-throughput

0.533

High

1413314

ANLN
Anillin

2

8

High-throughput

0.533

High

887184

CEBPA
CCAAT/enhancer-binding protein alpha

1

20

High-throughput

0.527

High

482535

F16P1
Fructose-1,6-bisphosphatase 1

1

0

High-throughput

0.513

High

1413315

ZC4H2
Zinc finger C4H2 domain-containing protein

1

0

High-throughput

0.513

High

423025

A4
Amyloid-beta precursor protein

1

11

High-throughput

0.501

High

964442

SUMO2
Small ubiquitin-related modifier 2

1

6

High-throughput

0.501

High

1413311

TNKS2
Poly [ADP-ribose] polymerase tankyrase-2

1

10

Small-scale

0.501

High

1371422

DVL3
Segment polarity protein dishevelled homolog DVL-3

1

13

High-throughput

0.494

High

169207

QCR10
Cytochrome b-c1 complex subunit 10

1

3

High-throughput

0.489

High

317085

DPM2
Dolichol phosphate-mannose biosynthesis regulatory protein

1

1

High-throughput

0.489

High

488078

IFI6
Interferon alpha-inducible protein 6

1

2

High-throughput

0.489

High

515902

SAA1
Serum amyloid A-1 protein

1

2

High-throughput

0.489

High

540270

SPTB1
Spectrin beta chain, erythrocytic

1

10

High-throughput

0.489

High

694389

CO8A1
Collagen alpha-1(VIII) chain

1

17

High-throughput

0.489

High

948581

APC15
Anaphase-promoting complex subunit 15

1

3

High-throughput

0.489

High

1092813

MALL
MAL-like protein

1

3

High-throughput

0.489

High

1093770

GAGE5
G antigen 5

1

5

High-throughput

0.489

High

1146619

TMED2
Transmembrane emp24 domain-containing protein 2

1

2

High-throughput

0.489

High

1187913

KR197
Keratin-associated protein 19-7

1

1

High-throughput

0.489

High

1196243

GAG2E
G antigen 2E

1

5

High-throughput

0.489

High

1217426

OBSCN
Obscurin

1

12

High-throughput

0.489

High

1218120

CP141
Cilia- and flagella-associated protein 141

1

1

High-throughput

0.489

High

1384721

I27L1
Interferon alpha-inducible protein 27-like protein 1

1

2

High-throughput

0.489

High

1388086

ERLEC
Endoplasmic reticulum lectin 1

1

1

High-throughput

0.489

High

1392162

RUSF1
RUS family member 1

1

1

High-throughput

0.489

High

1413318

TM14B
Transmembrane protein 14B

1

1

High-throughput

0.489

High

1413323

PEN2
Gamma-secretase subunit PEN-2

1

1

High-throughput

0.489

High

1413330

ANR50
Ankyrin repeat domain-containing protein 50

1

10

High-throughput

0.489

High

129381

MEN1
Menin

1

9

High-throughput

0.479

High

157795

CTRO
Citron Rho-interacting kinase

1

10

High-throughput

0.479

High

247419

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

8

High-throughput

0.479

High

285444

EED
Polycomb protein EED

1

20

High-throughput

0.479

High

331276

KI20A
Kinesin-like protein KIF20A

1

15

High-throughput

0.479

High

375894

RASK
GTPase KRas

1

9

High-throughput

0.479

High

401400

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

14

High-throughput

0.479

High

406577

MYCN
N-myc proto-oncogene protein

1

20

High-throughput

0.479

High

430300

JUN
Transcription factor Jun

1

20

High-throughput

0.479

High

447374

NPM
Nucleophosmin

1

4

Small-scale

0.479

High

461879

HS90A
Heat shock protein HSP 90-alpha

1

11

High-throughput

0.479

High

487695

PARP1
Poly [ADP-ribose] polymerase 1

1

20

Small-scale

0.479

High

520337

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

567474

TCTP
Translationally-controlled tumor protein

1

1

High-throughput

0.479

High

621731

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

6

High-throughput

0.479

High

675654

TYY1
Transcriptional repressor protein YY1

1

16

High-throughput

0.479

High

697239

APEX1
DNA repair nuclease/redox regulator APEX1

1

5

High-throughput

0.479

High

842848

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

15

High-throughput

0.479

High

862416

YAP1
Transcriptional coactivator YAP1

1

20

High-throughput

0.479

High

879413

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

20

High-throughput

0.479

High

905087

MECP2
Methyl-CpG-binding protein 2

1

18

High-throughput

0.479

High

980240

H4
Histone H4

1

16

High-throughput

0.479

High

986677

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

9

High-throughput

0.479

High

995231

CSK2B
Casein kinase II subunit beta

1

4

High-throughput

0.479

High

1008317

PRKDC
DNA-dependent protein kinase catalytic subunit

1

3

High-throughput

0.479

High

1008867

RED1
Double-stranded RNA-specific editase 1

1

16

High-throughput

0.479

High

1024806

VIGLN
Vigilin

1

12

High-throughput

0.479

High

1027708

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

20

Small-scale

0.479

High

1062621

DHX9
ATP-dependent RNA helicase A

1

9

Small-scale

0.479

High

1114158

CUL3
Cullin-3

1

20

High-throughput

0.479

High

1128814

NBR1
Next to BRCA1 gene 1 protein

1

1

High-throughput

0.479

High

1138575

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

9

High-throughput

0.479

High

1207428

HABP4
Intracellular hyaluronan-binding protein 4

1

7

High-throughput

0.479

High

1255305

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

1276720

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

17

High-throughput

0.479

High

1289590

NAA40
N-alpha-acetyltransferase 40

1

5

High-throughput

0.479

High

1313387

SMC5
Structural maintenance of chromosomes protein 5

1

17

High-throughput

0.479

High

1314389

SLX4
Structure-specific endonuclease subunit SLX4

1

20

High-throughput

0.479

High

1334847

SERB1
SERPINE1 mRNA-binding protein 1

1

7

High-throughput

0.479

High

1360120

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

3

High-throughput

0.479

High

1364232

TOPB1
DNA topoisomerase 2-binding protein 1

1

16

High-throughput

0.479

High

1364564

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

6

Small-scale

0.479

High

1380125

FBXW7
F-box/WD repeat-containing protein 7

1

15

High-throughput

0.479

High

1412804

PCGF1
Polycomb group RING finger protein 1

1

20

High-throughput

0.479

High

1413305

PRAX
Periaxin

1

18

High-throughput

0.479

High

1413306

FACD2
Fanconi anemia group D2 protein

1

2

High-throughput

0.479

High

1413307

WWTR1
WW domain-containing transcription regulator protein 1

1

20

High-throughput

0.479

High

1413310

VPS11
Vacuolar protein sorting-associated protein 11 homolog

1

1

High-throughput

0.479

High

1413312

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

1413316

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

13

High-throughput

0.479

High

1413317

SMC4
Structural maintenance of chromosomes protein 4

1

14

High-throughput

0.479

High

1413319

TBA8
Tubulin alpha-8 chain

1

5

High-throughput

0.479

High

1413321

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

8

High-throughput

0.479

High

1413324

WWOX
WW domain-containing oxidoreductase

1

4

High-throughput

0.479

High

1413327

HECW2
E3 ubiquitin-protein ligase HECW2

1

20

High-throughput

0.479

High

1413328

ZRAN1
Ubiquitin thioesterase ZRANB1

1

20

High-throughput

0.479

High

1413334

TRRAP
Transformation/transcription domain-associated protein

1

3

High-throughput

0.479

High

822842

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.460

High

187399

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

0

High-throughput

0.458

High

1413309

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

0

High-throughput

0.458

High

516448

CALM2
Calmodulin-2

1

2

High-throughput

0.445

High

516580

CALM3
Calmodulin-3

1

2

High-throughput

0.445

High

584139

FOSL2
Fos-related antigen 2

1

16

High-throughput

0.445

High

1108389

MED21
Mediator of RNA polymerase II transcription subunit 21

1

2

High-throughput

0.445

High

1111234

SNW1
SNW domain-containing protein 1

1

5

High-throughput

0.445

High

1219144

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

1

8

High-throughput

0.445

High

1404354

CDC5L
Cell division cycle 5-like protein

1

14

High-throughput

0.445

High

1413313

LN28A
Protein lin-28 homolog A

1

3

High-throughput

0.445

High

1413325

VSX1
Visual system homeobox 1

1

20

High-throughput

0.445

High

1413326

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

3

High-throughput

0.445

High

1413329

PARP2
Poly [ADP-ribose] polymerase 2

1

12

Small-scale

0.445

High

1041644

TGBR3
Transforming growth factor beta receptor type 3

1

1

High-throughput

0.437

High

1413331

HECD1
E3 ubiquitin-protein ligase HECTD1

1

20

High-throughput

0.437

High

62589

S35F4
Solute carrier family 35 member F4

1

1

High-throughput

0.407

High

789006

TGFR2
TGF-beta receptor type-2

1

2

High-throughput

0.407

High

1064014

ECHP
Peroxisomal bifunctional enzyme

1

1

High-throughput

0.407

High

1413322

KCNK4
Potassium channel subfamily K member 4

1

0

High-throughput

0.282

High

1142810

PEA15
Astrocytic phosphoprotein PEA-15

1

0

High-throughput

0.279

Low

1218824

FOCAD
Focadhesin

1

0

High-throughput

0.279

Low

852652

ABCG1
ATP-binding cassette sub-family G member 1

1

0

High-throughput

0.249

Low

1162521

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025