HitPredict

Interactor 1: RIPK4 (P57078)
Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase)
Gene: RIPK4

Interactor 2: KSR1 (Q8IVT5)
Kinase suppressor of Ras 1 (EC 2.7.11.1)
Gene: KSR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	26972000
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0004674 - protein serine/threonine kinase activity GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0016020 - membrane GO:0016310 - phosphorylation and 1 others more... GO:0106310 - protein serine kinase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 832 Hs			1 923
+	Hs
		1217986 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		KSR1_HUMAN (1-923): 0: 765: 100.00
+	Hs
		488633 RIPK4_HUMAN (1-832): 0: 726: 100.00		ARAF_HUMAN (261-899): 1.38e-148: 454: 24.55
+	Hs
		373957 RIPK4_HUMAN (1-832): 0: 726: 100.00		RAF1_HUMAN (229-908): 9.62e-143: 440: 22.03
+	Hs
		488803 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		ARAF_HUMAN (261-899): 1.38e-148: 454: 24.55
+	Hs
		374864 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		RAF1_HUMAN (229-908): 9.62e-143: 440: 22.03
+	Hs
		600539 DAPK1_HUMAN (513-831): 7.19e-83: 292: 25.16		EPHA1_HUMAN (223-917): 1.29e-138: 439: 15.72
+	Hs
		201842 RIPK2_HUMAN (31-276): 6.59e-54: 197: 44.94		M3K4_HUMAN (39-876): 3.74e-168: 533: 16.52
+	Hs
		600670 TNKS2_HUMAN (490-831): 4.65e-82: 287: 25.71		EPHA1_HUMAN (223-917): 1.29e-138: 439: 15.72
+	Hs
		665439 KDIS_HUMAN (251-655): 7.94e-53: 202: 18.63		EPHA3_HUMAN (206-888): 1.72e-170: 523: 14.58
+	Hs
		665581 ANK2_HUMAN (592-832): 1.31e-65: 241: 27.89		EPHB2_HUMAN (223-895): 5.19e-149: 469: 14.82
+	Hs
		374070 ANK2_HUMAN (592-832): 1.31e-65: 241: 27.89		RAF1_HUMAN (229-908): 9.62e-143: 440: 22.03
+	Hs
		872504 KDIS_HUMAN (251-655): 7.94e-53: 202: 18.63		EPHA5_HUMAN (223-888): 4.57e-149: 469: 14.15
+	Mm
		93731 E9Q9B7_MOUSE (251-655): 1.01e-52: 202: 18.38		BRAF_MOUSE (252-914): 2.44e-148: 458: 22.95
+	Hs
		665360 KDIS_HUMAN (251-655): 7.94e-53: 202: 18.63		EPHA2_HUMAN (223-917): 2.52e-144: 454: 14.62
+	Hs
		665591 ANK3_HUMAN (659-832): 4.77e-45: 178: 32.57		EPHB2_HUMAN (223-895): 5.19e-149: 469: 14.82
+	Hs
		872734 RIPK3_HUMAN (21-371): 4.07e-34: 139: 30.39		EPHA4_HUMAN (206-912): 6.5e-164: 506: 14.77
+	Hs
		201737 RIPK2_HUMAN (31-276): 6.59e-54: 197: 44.94		RAF1_HUMAN (229-908): 9.62e-143: 440: 22.03
+	Hs
		374141 ANK3_HUMAN (659-832): 4.77e-45: 178: 32.57		RAF1_HUMAN (229-908): 9.62e-143: 440: 22.03
+	Hs
		411885 KDIS_HUMAN (251-655): 7.94e-53: 202: 18.63		LCK_HUMAN (591-890): 2.14e-99: 322: 24.59
+	Hs
		411697 ANK3_HUMAN (659-832): 4.77e-45: 178: 32.57		LCK_HUMAN (591-890): 2.14e-99: 322: 24.59