HitPredict

Interactor 1: RIPK4 (P57078)
Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase)
Gene: RIPK4

Interactor 2: SPAST (Q9UBP0)
Spastin (EC 5.6.1.1) (Spastic paraplegia 4 protein)
Gene: SPAST

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	35914814
Identification Methods	two hybrid fragment pooling approach
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AAA_lid_3~Ank_2, AAA_lid_3~Ank_4
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 832 Hs			1 616
+	Hs
		1330872 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		SPAST_HUMAN (1-616): 2.86e-168: 494: 100.00
+	Hs
		883669 RIPK4_HUMAN (1-832): 0: 726: 100.00		VPS4A_HUMAN (290-615): 5.95e-112: 343: 36.54
+	Hs
		883564 RIPK4_HUMAN (1-832): 0: 726: 100.00		AFG2A_HUMAN (44-616): 2.52e-98: 321: 21.69
+	Hs
		1330880 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		VPS4A_HUMAN (290-615): 5.95e-112: 343: 36.54
+	Hs
		1239604 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		AFG2A_HUMAN (44-616): 2.52e-98: 321: 21.69
+	Hs
		874739 RIPK4_HUMAN (1-832): 0: 726: 100.00		TERA_HUMAN (8-346): 2.68e-20: 97.3: 8.86
+	Hs
		875317 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		TERA_HUMAN (8-346): 2.68e-20: 97.3: 8.86
+	Mm
		1208058 ANK2_MOUSE (592-832): 1.3e-65: 241: 27.89		SPAST_MOUSE (1-616): 6.34e-165: 486: 91.56
+	Hs
		875096 ANKH1_HUMAN (384-541): 3.69e-19: 95.3: 14.47		TERA_HUMAN (8-346): 2.68e-20: 97.3: 8.86