HitPredict

Interactor 1: CENPA (P49450)
Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A)
Gene: CENPA

Interactor 2: SP16H (Q9Y5B9)
FACT complex subunit SPT16 (Chromatin-specific transcription elongation factor 140 kDa subunit) (FACT 140 kDa subunit) (FACTp140) (Facilitates chromatin transcription complex subunit SPT16) (hSPT16)
Gene: SUPT16H

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.895

Property	Details
Experiments	28514442, 34079125, 33961781, 16622419
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~Rttp106-like_middle
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 140 Hs			1 1047
+	Hs
		999004 H31_HUMAN (5-134): 1.3e-52: 164: 48.86		SP16H_HUMAN (1-1047): 0: 1331: 100.00
+	Mm
		1017371 H33_MOUSE (5-134): 1.58e-51: 161: 49.62		SP16H_MOUSE (1-1047): 0: 1332: 98.66
+	Hs
		1239496 H3C_HUMAN (5-134): 5.17e-52: 162: 47.69		SP16H_HUMAN (1-1047): 0: 1331: 100.00
+	Hs
		1017334 H33_HUMAN (5-134): 1.58e-51: 161: 49.62		SP16H_HUMAN (1-1047): 0: 1331: 100.00
+	Hs
		1258993 H32_HUMAN (5-134): 1.74e-51: 161: 48.86		SP16H_HUMAN (1-1047): 0: 1331: 100.00
+	Sp
		313587 H31_SCHPO (5-134): 4.98e-49: 155: 48.09		SPT16_SCHPO (3-1016): 0: 1010: 37.43
+	Sp
		313593 CENPA_SCHPO (35-134): 1.13e-44: 143: 53.85		SPT16_SCHPO (3-1016): 0: 1010: 37.43
+	Sc
		739593 CENPA_YEAST (24-134): 1.25e-44: 147: 45.54		SPT16_YEAST (3-1008): 0: 938: 33.49
+	Sc
		739719 H3_YEAST (5-134): 5.28e-46: 147: 46.57		SPT16_YEAST (3-1008): 0: 938: 33.49