Protein: H3C
Histone H3.3C (Histone H3.5)

Gene: H3C, H3-5
Organism: Homo sapiens
Interactions: 135
UniProt ID: Q6NXT2

Gene Ontology (top 5):
GO:0000786 - nucleosome
GO:0000791 - euchromatin
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0030307 - positive regulation of cell growth

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

881060

NASP
Nuclear autoantigenic sperm protein

4

16

High-throughput

0.901

High

1239487

DAXX
Death domain-associated protein 6

2

5

High-throughput

0.783

High

502391

H2A1
Histone H2A type 1

2

20

High-throughput

0.754

High

521752

H14
Histone H1.4

2

20

High-throughput

0.754

High

595801

H13
Histone H1.3

2

20

High-throughput

0.754

High

979838

H4
Histone H4

2

17

High-throughput

0.754

High

998443

H31
Histone H3.1

2

16

High-throughput

0.754

High

1037213

H11
Histone H1.1

2

20

High-throughput

0.754

High

1239470

H2A1J
Histone H2A type 1-J

2

20

High-throughput

0.754

High

856744

BAG6
Large proline-rich protein BAG6

1

20

High-throughput

0.665

High

1031910

NC2B
Protein Dr1

1

2

High-throughput

0.665

High

216462

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

20

High-throughput

0.656

High

246683

KDM1A
Lysine-specific histone demethylase 1A

1

13

High-throughput

0.656

High

1199859

SETMR
Histone-lysine N-methyltransferase SETMAR

1

20

High-throughput

0.656

High

1239454

SMYD1
Histone-lysine N-methyltransferase SMYD1

1

7

High-throughput

0.656

High

1239475

NSD3
Histone-lysine N-methyltransferase NSD3

1

20

High-throughput

0.656

High

1239481

SMYD3
Histone-lysine N-methyltransferase SMYD3

1

7

High-throughput

0.656

High

1239459

KAT6A
Histone acetyltransferase KAT6A

1

20

Small-scale

0.647

High

256896

H2B1K
Histone H2B type 1-K

1

20

High-throughput

0.618

High

342918

HERC2
E3 ubiquitin-protein ligase HERC2

1

7

High-throughput

0.618

High

419035

H2A1B
Histone H2A type 1-B/E

1

20

High-throughput

0.618

High

449736

H2B1J
Histone H2B type 1-J

1

20

High-throughput

0.618

High

455801

H10
Histone H1.0

1

4

High-throughput

0.618

High

507234

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

17

High-throughput

0.618

High

508143

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

17

High-throughput

0.618

High

591691

H2AX
Histone H2AX

1

20

High-throughput

0.618

High

595476

H15
Histone H1.5

1

20

High-throughput

0.618

High

596171

H12
Histone H1.2

1

20

High-throughput

0.618

High

634036

H2A1D
Histone H2A type 1-D

1

20

High-throughput

0.618

High

649337

H1T
Histone H1t

1

20

High-throughput

0.618

High

853304

CBX5
Chromobox protein homolog 5

1

20

High-throughput

0.618

High

943373

H2BFS
Histone H2B type F-S

1

20

High-throughput

0.618

High

946806

H2B1D
Histone H2B type 1-D

1

20

High-throughput

0.618

High

987075

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

16

High-throughput

0.618

High

987385

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

15

High-throughput

0.618

High

1016953

H33
Histone H3.3

1

15

High-throughput

0.618

High

1132762

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

20

High-throughput

0.618

High

1154851

NEDD8
Ubiquitin-like protein NEDD8

1

19

High-throughput

0.618

High

1155464

EZH2
Histone-lysine N-methyltransferase EZH2

1

20

High-throughput

0.618

High

1161906

H31T
Histone H3.1t

1

15

High-throughput

0.618

High

1162804

H2A2C
Histone H2A type 2-C

1

20

High-throughput

0.618

High

1162992

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.618

High

1210458

HP1B3
Heterochromatin protein 1-binding protein 3

1

4

High-throughput

0.618

High

1232680

H2A2A
Histone H2A type 2-A

1

20

High-throughput

0.618

High

1239446

H32
Histone H3.2

1

14

High-throughput

0.618

High

1239447

H2AV
Histone H2A.V

1

20

High-throughput

0.618

High

1239448

H2A3
Histone H2A type 3

1

20

High-throughput

0.618

High

1239460

H2A1C
Histone H2A type 1-C

1

20

High-throughput

0.618

High

1239461

H2B1H
Histone H2B type 1-H

1

20

High-throughput

0.618

High

1239466

H2A1H
Histone H2A type 1-H

1

20

High-throughput

0.618

High

1239471

H2B1L
Histone H2B type 1-L

1

20

High-throughput

0.618

High

1239473

H2AJ
Histone H2A.J

1

20

High-throughput

0.618

High

1239477

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

4

High-throughput

0.618

High

1239486

H2AW
Core histone macro-H2A.2

1

20

High-throughput

0.618

High

1239488

BAZ1B
Tyrosine-protein kinase BAZ1B

1

20

High-throughput

0.618

High

1239490

PHF8
Histone lysine demethylase PHF8

1

20

High-throughput

0.618

High

1239496

SP16H
FACT complex subunit SPT16

1

9

High-throughput

0.618

High

1239456

DNJC9
DnaJ homolog subfamily C member 9

2

14

High-throughput

0.606

High

1239458

DPF3
Zinc finger protein DPF3

1

20

Small-scale

0.575

High

702356

ELK4
ETS domain-containing protein Elk-4

2

12

High-throughput

0.571

High

908129

KS6A3
Ribosomal protein S6 kinase alpha-3

2

14

High-throughput

0.571

High

1145876

RBP1
RalA-binding protein 1

2

9

High-throughput

0.571

High

1239479

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

2

15

High-throughput

0.571

High

1239491

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

2

6

High-throughput

0.571

High

1239455

FBLI1
Filamin-binding LIM protein 1

2

3

High-throughput

0.553

High

1220991

FBW10
F-box/WD repeat-containing protein 10

1

15

High-throughput

0.553

High

1239453

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.546

High

1136450

FL2D
Pre-mRNA-splicing regulator WTAP

1

2

High-throughput

0.536

High

1239449

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

2

High-throughput

0.536

High

167287

KLF11
Krueppel-like factor 11

1

14

High-throughput

0.515

High

843667

HD
Huntingtin

1

2

High-throughput

0.515

High

981547

RAN
GTP-binding nuclear protein Ran

1

6

High-throughput

0.515

High

1239494

RNF11
RING finger protein 11

1

2

High-throughput

0.515

High

1239497

TF3C3
General transcription factor 3C polypeptide 3

1

11

High-throughput

0.515

High

162608

ANM5
Protein arginine N-methyltransferase 5

1

14

High-throughput

0.508

High

322666

KDM4B
Lysine-specific demethylase 4B

1

20

High-throughput

0.508

High

1239467

ANM6
Protein arginine N-methyltransferase 6

1

16

High-throughput

0.508

High

1239485

ANM7
Protein arginine N-methyltransferase 7

1

16

High-throughput

0.508

High

274628

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.493

High

937037

CASP6
Caspase-6

1

0

High-throughput

0.493

High

223130

PRC1
Protein regulator of cytokinesis 1

1

4

High-throughput

0.479

High

226802

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

6

High-throughput

0.479

High

331055

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

350045

SNAI1
Zinc finger protein SNAI1

1

12

High-throughput

0.479

High

447117

NPM
Nucleophosmin

1

5

High-throughput

0.479

High

487436

PARP1
Poly [ADP-ribose] polymerase 1

1

16

High-throughput

0.479

High

601731

HMGA1
High mobility group protein HMG-I/HMG-Y

1

5

High-throughput

0.479

High

620422

NUCL
Nucleolin

1

6

High-throughput

0.479

High

687253

HMGB2
High mobility group protein B2

1

20

High-throughput

0.479

High

693797

RL10
Large ribosomal subunit protein uL16

1

2

High-throughput

0.479

High

755960

MCM5
DNA replication licensing factor MCM5

1

20

High-throughput

0.479

High

881546

CDK8
Cyclin-dependent kinase 8

1

7

High-throughput

0.479

High

913519

KIF11
Kinesin-like protein KIF11

1

14

High-throughput

0.479

High

1035701

KIF23
Kinesin-like protein KIF23

1

19

High-throughput

0.479

High

1039519

TOP2B
DNA topoisomerase 2-beta

1

13

High-throughput

0.479

High

1137773

TNIP1
TNFAIP3-interacting protein 1

1

12

High-throughput

0.479

High

1140427

KIF14
Kinesin-like protein KIF14

1

12

High-throughput

0.479

High

1239451

SMC5
Structural maintenance of chromosomes protein 5

1

13

High-throughput

0.479

High

1239464

SPDLY
Protein Spindly

1

10

High-throughput

0.479

High

1239465

AURKB
Aurora kinase B

1

20

High-throughput

0.479

High

1239468

CI072
Guanine nucleotide exchange factor C9orf72

1

4

High-throughput

0.479

High

1239469

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

1239472

OVOL2
Transcription factor Ovo-like 2

1

10

Small-scale

0.479

High

1239474

TRI55
Tripartite motif-containing protein 55

1

15

High-throughput

0.479

High

1239480

CHM4B
Charged multivesicular body protein 4b

1

3

High-throughput

0.479

High

1239482

ECT2
Protein ECT2

1

2

High-throughput

0.479

High

1239483

ANLN
Anillin

1

2

High-throughput

0.479

High

1239484

DJC11
DnaJ homolog subfamily C member 11

1

8

High-throughput

0.479

High

1239492

FAN1
Fanconi-associated nuclease 1

1

1

High-throughput

0.479

High

1239495

TRRAP
Transformation/transcription domain-associated protein

1

10

High-throughput

0.479

High

245984

KIF1B
Kinesin-like protein KIF1B

1

8

High-throughput

0.470

High

301489

WFS1
Wolframin

1

1

High-throughput

0.470

High

562146

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.470

High

705412

GRN
Progranulin

1

1

High-throughput

0.470

High

719955

HMOX2
Heme oxygenase 2

1

2

High-throughput

0.470

High

1105890

LSAMP
Limbic system-associated membrane protein

1

2

High-throughput

0.470

High

1239489

ICAM5
Intercellular adhesion molecule 5

1

8

High-throughput

0.470

High

1239493

SHLB1
Endophilin-B1

1

2

High-throughput

0.470

High

1239478

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

157505

CTRO
Citron Rho-interacting kinase

1

6

High-throughput

0.437

High

272261

OBSL1
Obscurin-like protein 1

1

3

High-throughput

0.437

High

585798

PHKG2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

1

9

High-throughput

0.437

High

959186

ABCE1
ATP-binding cassette sub-family E member 1

1

4

High-throughput

0.437

High

1134951

CUL7
Cullin-7

1

7

High-throughput

0.437

High

1218336

OTUD1
OTU domain-containing protein 1

1

5

High-throughput

0.437

High

1239445

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.437

High

1239450

CUL9
Cullin-9

1

8

High-throughput

0.437

High

1239452

FBXW8
F-box/WD repeat-containing protein 8

1

10

High-throughput

0.437

High

1239457

TCPW
T-complex protein 1 subunit zeta-2

1

7

High-throughput

0.437

High

1239463

CHM4C
Charged multivesicular body protein 4c

1

3

High-throughput

0.437

High

1239476

TRIM4
E3 ubiquitin-protein ligase TRIM4

1

4

Small-scale

0.437

High

441547

CCKN
Cholecystokinin

1

0

High-throughput

0.268

Low

1239462

COQA1
Collagen alpha-1(XXVI) chain

1

0

High-throughput

0.268

Low

914278

EFNA4
Ephrin-A4

1

0

High-throughput

0.249

Low

1049163

RON
Macrophage-stimulating protein receptor

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025