HitPredict

Interactor 1: EPIPL (P58107)
Epiplakin (450 kDa epidermal antigen)
Gene: EPPK1

Interactor 2: K2C78 (Q8N1N4)
Keratin, type II cytoskeletal 78 (Cytokeratin-78) (CK-78) (Keratin-5b) (Keratin-78) (K78) (Type-II keratin Kb40)
Gene: KRT78

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0045095 - keratin filament GO:0045109 - intermediate filament organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 5088 Hs			1 520
+	Hs
		444531 EPIPL_HUMAN (1-5088): 0: 4242: 100.00		K2C7_HUMAN (12-435): 4.77e-122: 367: 53.30
+	Hs
		409039 EPIPL_HUMAN (1-5088): 0: 4242: 100.00		K2C8_HUMAN (83-465): 4.86e-121: 365: 55.09
+	Hs
		213934 EPIPL_HUMAN (1-5088): 0: 4242: 100.00		KRT86_HUMAN (1-499): 1.62e-103: 321: 39.88
+	Hs
		885269 EPIPL_HUMAN (1-5088): 0: 4242: 100.00		K2C73_HUMAN (4-513): 9.84e-99: 310: 50.19
+	Hs
		318791 EPIPL_HUMAN (1-5088): 0: 4242: 100.00		K2C75_HUMAN (2-516): 7.92e-95: 300: 48.22
+	Hs
		885321 EPIPL_HUMAN (1-5088): 0: 4242: 100.00		KRT82_HUMAN (1-506): 6.2e-86: 276: 41.18
+	Hs
		885251 EPIPL_HUMAN (1-5088): 0: 4242: 100.00		K2C72_HUMAN (1-502): 4.44e-85: 274: 47.85
+	Hs
		580127 EPIPL_HUMAN (1-5088): 0: 4242: 100.00		K2C4_HUMAN (6-443): 3.19e-73: 243: 55.10
+	Hs
		517744 EPIPL_HUMAN (1-5088): 0: 4242: 100.00		K2C3_HUMAN (83-428): 5.14e-68: 232: 62.07
+	Hs
		885248 EPIPL_HUMAN (1-5088): 0: 4242: 100.00		K1H2_HUMAN (14-424): 4.34e-69: 230: 21.90
+	Hs
		409080 PLEC_HUMAN (1149-4489): 2.53e-72: 275: 17.38		K2C8_HUMAN (83-465): 4.86e-121: 365: 55.09
+	Mm
		93550 DESP_MOUSE (2495-4527): 3.06e-49: 198: 11.94		K22E_MOUSE (83-427): 7.8e-117: 362: 54.78
+	Hs
		821662 PLEC_HUMAN (1149-4489): 2.53e-72: 275: 17.38		K2C6C_HUMAN (76-448): 1.24e-79: 261: 59.52
+	Hs
		1068595 PLEC_HUMAN (1149-4489): 2.53e-72: 275: 17.38		K2C78_HUMAN (1-520): 1.25e-79: 259: 100.00
+	Hs
		408995 DESP_HUMAN (2873-5087): 3.05e-30: 135: 10.82		K2C8_HUMAN (83-465): 4.86e-121: 365: 55.09
+	Hs
		234174 PEPL_HUMAN (2575-3932): 2.76e-26: 122: 10.40		K2C8_HUMAN (83-465): 4.86e-121: 365: 55.09
+	Hs
		380553 DESP_HUMAN (2873-5087): 3.05e-30: 135: 10.82		K2C1_HUMAN (76-442): 7.29e-112: 347: 56.95
+	Hs
		409163 NIN_HUMAN (2307-3806): 1.16e-14: 84: 9.19		K2C8_HUMAN (83-465): 4.86e-121: 365: 55.09
+	Hs
		359462 DESP_HUMAN (2873-5087): 3.05e-30: 135: 10.82		K2C6A_HUMAN (76-448): 1.02e-78: 258: 59.79
+	Hs
		531529 DESP_HUMAN (2873-5087): 3.05e-30: 135: 10.82		K2C5_HUMAN (76-427): 3.19e-78: 258: 62.50