HitPredict

Interactor 1: SC61B (P60468)
Protein transport protein Sec61 subunit beta
Gene: SEC61B

Interactor 2: S61A1 (P61619)
Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1)
Gene: SEC61A1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	1.00	0.956

Property	Details
Experiments	18555783, 26085089, 32788342, 34079125, 35271311, 37071682, 9585408
Identification Methods	affinity chromatography technology, proximity labelling technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Plug_translocon~Sec61_beta, Sec61_beta~SecY
Common GO terms	GO:0005784 - Sec61 translocon complex GO:0005789 - endoplasmic reticulum membrane GO:0006616 - SRP-dependent cotranslational protein targeting to membrane, translocation GO:0016020 - membrane GO:0031204 - post-translational protein targeting to membrane, translocation and 1 others more... GO:0043022 - ribosome binding
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 96 Hs			1 476
+	Hs
		890431 SC61B_HUMAN (1-96): 7.84e-32: 108: 100.00		S61A2_HUMAN (1-476): 0: 720: 93.49
+	Bt
		1102038 Q2NKT5_BOVIN (1-96): 8.47e-32: 108: 98.96		S61A1_BOVIN (1-476): 0: 719: 99.37
+	Sc
		701506 SC6B2_YEAST (11-94): 2.33e-28: 99.5: 21.43		SC61A_YEAST (4-464): 0: 589: 56.80
+	Sc
		701505 SC6B1_YEAST (22-93): 7.22e-20: 77.9: 23.68		SC61A_YEAST (4-464): 0: 589: 56.80
+	Sc
		749042 SC6B2_YEAST (11-94): 2.33e-28: 99.5: 21.43		SSH1_YEAST (2-474): 1.5e-165: 477: 30.31
+	Sc
		749041 SC6B1_YEAST (22-93): 7.22e-20: 77.9: 23.68		SSH1_YEAST (2-474): 1.5e-165: 477: 30.31