Protein: PSN2
Presenilin-2 (PS-2) (EC 3.4.23.-) (AD3LP) (AD5) (E5-1) (STM-2) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit]

Gene: PSN2, PSEN2
Organism: Homo sapiens
Interactions: 111
UniProt ID: P49810

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0000776 - kinetochore
GO:0001666 - response to hypoxia
GO:0005637 - nuclear inner membrane
GO:0005769 - early endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

889943

PSN1
Presenilin-1

3

7

Small-scale

0.850

High

421729

A4
Amyloid-beta precursor protein

3

2

Small-scale

0.843

High

890765

APH1A
Gamma-secretase subunit APH-1A

3

10

Small-scale

0.839

High

890780

PEN2
Gamma-secretase subunit PEN-2

3

7

Small-scale

0.827

High

890759

APH1B
Gamma-secretase subunit APH-1B

2

10

Small-scale

0.754

High

890782

UBQL1
Ubiquilin-1

3

3

Small-scale

0.672

High

890762

NICA
Nicastrin

3

6

Small-scale

0.650

High

890773

CIB1
Calcium and integrin-binding protein 1

2

4

Small-scale

0.628

High

890785

CSEN
Calsenilin

2

4

Small-scale

0.620

High

890715

PSN2
Presenilin-2

1

7

Small-scale

0.618

High

890786

TRAF6
TNF receptor-associated factor 6

2

1

Small-scale

0.601

High

721145

SORCN
Sorcin

1

2

Small-scale

0.578

High

278042

FLNB
Filamin-B

1

5

Small-scale

0.573

High

890725

B2CL1
Bcl-2-like protein 1

1

4

Small-scale

0.573

High

890732

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.557

High

457064

CAN1
Calpain-1 catalytic subunit

1

2

Small-scale

0.552

High

890747

KCIP4
Kv channel-interacting protein 4

1

4

Small-scale

0.552

High

890736

RHEB
GTP-binding protein Rheb

1

2

High-throughput

0.541

High

890745

PDCD4
Programmed cell death protein 4

1

2

High-throughput

0.539

High

890774

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

1

High-throughput

0.539

High

890754

EXOC6
Exocyst complex component 6

1

0

High-throughput

0.518

High

890784

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

0

High-throughput

0.518

High

391207

FRIL
Ferritin light chain

1

1

High-throughput

0.515

High

699649

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

1

High-throughput

0.515

High

890722

H31
Histone H3.1

1

1

High-throughput

0.515

High

890739

BAK
Bcl-2 homologous antagonist/killer

1

4

High-throughput

0.515

High

890741

SGSM1
Small G protein signaling modulator 1

1

1

High-throughput

0.515

High

890778

S6A13
Sodium- and chloride-dependent GABA transporter 2

1

1

High-throughput

0.515

High

890755

NPL4
Nuclear protein localization protein 4 homolog

1

0

High-throughput

0.513

High

890787

RN115
E3 ubiquitin-protein ligase RNF115

1

0

High-throughput

0.513

High

637403

FLNA
Filamin-A

1

5

Small-scale

0.506

High

225787

AP1G1
AP-1 complex subunit gamma-1

1

1

Small-scale

0.501

High

890721

CSK21
Casein kinase II subunit alpha

1

2

Small-scale

0.501

High

890781

ICAM5
Intercellular adhesion molecule 5

1

2

Small-scale

0.501

High

679100

DNJB1
DnaJ homolog subfamily B member 1

1

3

High-throughput

0.494

High

890777

RNF32
RING finger protein 32

1

1

High-throughput

0.494

High

890779

FXL12
F-box/LRR-repeat protein 12

1

1

High-throughput

0.494

High

890788

ALG5
Dolichyl-phosphate beta-glucosyltransferase

1

0

High-throughput

0.493

High

712837

CASP1
Caspase-1

1

0

High-throughput

0.493

High

890758

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

1

0

High-throughput

0.493

High

890775

UBAC1
Ubiquitin-associated domain-containing protein 1

1

0

High-throughput

0.493

High

713074

NOS3
Nitric oxide synthase 3

1

1

High-throughput

0.481

High

890728

IFIT5
Interferon-induced protein with tetratricopeptide repeats 5

1

1

High-throughput

0.481

High

890730

AAMP
Angio-associated migratory cell protein

1

3

High-throughput

0.481

High

170018

AURKA
Aurora kinase A

1

0

Small-scale

0.480

High

876775

KC1A
Casein kinase I isoform alpha

1

0

Small-scale

0.480

High

210179

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

1

Small-scale

0.479

High

355070

APBA3
Amyloid-beta A4 precursor protein-binding family A member 3

1

4

Small-scale

0.479

High

522062

BCL2
Apoptosis regulator Bcl-2

1

4

Small-scale

0.479

High

890716

PPP5
Serine/threonine-protein phosphatase 5

1

1

High-throughput

0.479

High

890719

TSN5
Tetraspanin-5

1

1

High-throughput

0.479

High

890723

DLK1
Protein delta homolog 1

1

12

High-throughput

0.479

High

890724

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

4

Small-scale

0.479

High

890733

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

1

Small-scale

0.479

High

890735

KIF22
Kinesin-like protein KIF22

1

1

High-throughput

0.479

High

890740

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

890767

FAF2
FAS-associated factor 2

1

1

High-throughput

0.479

High

890772

APBA2
Amyloid-beta A4 precursor protein-binding family A member 2

1

4

Small-scale

0.479

High

62328

A4FUJ8
MKL1 protein

1

1

High-throughput

0.470

High

302154

NEBL
Nebulette

1

1

High-throughput

0.470

High

318963

MICA2
[F-actin]-monooxygenase MICAL2

1

5

High-throughput

0.470

High

890726

ARL16
ADP-ribosylation factor-like protein 16

1

2

High-throughput

0.470

High

890727

PDZ1I
PDZK1-interacting protein 1

1

1

High-throughput

0.470

High

890750

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.470

High

890757

HUMMR
Protein MGARP

1

1

High-throughput

0.470

High

890768

MR1L1
MORF4 family-associated protein 1-like 1

1

1

High-throughput

0.470

High

890770

ZMAT2
Zinc finger matrin-type protein 2

1

1

High-throughput

0.470

High

890776

SKI8
Superkiller complex protein 8

1

4

High-throughput

0.470

High

249965

OGA
Protein O-GlcNAcase

1

0

High-throughput

0.460

High

890720

ACTG
Actin, cytoplasmic 2

1

0

High-throughput

0.460

High

890737

ELAV1
ELAV-like protein 1

1

0

High-throughput

0.460

High

890746

CEP55
Centrosomal protein of 55 kDa

1

0

High-throughput

0.460

High

890753

SPC24
Kinetochore protein Spc24

1

0

High-throughput

0.460

High

890729

NAR3
Ecto-ADP-ribosyltransferase 3

1

0

High-throughput

0.458

High

890783

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

0

High-throughput

0.458

High

303219

S22A5
Organic cation/carnitine transporter 2

1

1

High-throughput

0.445

High

722416

CTR1
High affinity cationic amino acid transporter 1

1

2

High-throughput

0.445

High

870212

S6A12
Sodium- and chloride-dependent betaine transporter

1

1

High-throughput

0.445

High

890738

VAMP3
Vesicle-associated membrane protein 3

1

1

High-throughput

0.445

High

890756

S7A14
Solute carrier family 7 member 14

1

2

High-throughput

0.445

High

890760

CTR3
Cationic amino acid transporter 3

1

2

High-throughput

0.445

High

890761

S39A7
Zinc transporter SLC39A7

1

1

High-throughput

0.445

High

166763

IFIT3
Interferon-induced protein with tetratricopeptide repeats 3

1

1

High-throughput

0.439

High

570380

GFAP
Glial fibrillary acidic protein

1

1

Small-scale

0.439

High

890764

GCDH
Glutaryl-CoA dehydrogenase, mitochondrial

1

1

High-throughput

0.439

High

890769

MF14A
Hippocampus abundant transcript 1 protein

1

0

High-throughput

0.426

High

890749

S22A9
Organic anion transporter 7

1

1

High-throughput

0.407

High

890731

FHL2
Four and a half LIM domains protein 2

1

0

Small-scale

0.305

High

450197

LIPF
Gastric triacylglycerol lipase

1

0

High-throughput

0.282

High

889377

CLK1
Dual specificity protein kinase CLK1

1

0

High-throughput

0.269

Low

890734

IRF3
Interferon regulatory factor 3

1

0

High-throughput

0.269

Low

137321

ELL2
RNA polymerase II elongation factor ELL2

1

0

High-throughput

0.268

Low

336283

SOX14
Transcription factor SOX-14

1

0

High-throughput

0.268

Low

833085

MNDA
Myeloid cell nuclear differentiation antigen

1

0

High-throughput

0.268

Low

890717

KAD2
Adenylate kinase 2, mitochondrial

1

0

High-throughput

0.268

Low

890742

ZXDC
Zinc finger protein ZXDC

1

0

High-throughput

0.268

Low

890743

SP6
Transcription factor Sp6

1

0

High-throughput

0.268

Low

890744

FX4L6
Forkhead box protein D4-like 6

1

0

High-throughput

0.268

Low

890748

Q86WV2
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.268

Low

890751

ZN366
Zinc finger protein 366

1

0

High-throughput

0.268

Low

890752

ZSCA1
Zinc finger and SCAN domain-containing protein 1

1

0

High-throughput

0.268

Low

890771

RING2
E3 ubiquitin-protein ligase RING2

1

0

High-throughput

0.268

Low

890789

EID1
EP300-interacting inhibitor of differentiation 1

1

0

High-throughput

0.265

Low

700778

DMB
HLA class II histocompatibility antigen, DM beta chain

1

0

High-throughput

0.261

Low

351088

ECD
Protein ecdysoneless homolog

1

0

High-throughput

0.251

Low

776916

CHKA
Choline kinase alpha

1

0

High-throughput

0.251

Low

890763

HPS1
BLOC-3 complex member HPS1

1

0

High-throughput

0.251

Low

890766

EVI5L
EVI5-like protein

1

0

High-throughput

0.251

Low

293380

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

890718

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025