HitPredict

Interactor 1: GBRL2 (P60520)
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABA(A) receptor-associated protein-like 2) (Ganglioside expression factor 2) (GEF-2) (General protein transport factor p16) (Golgi-associated ATPase enhancer of 16 kDa) (GATE-16) (MAP1 light chain 3-related protein)
Gene: GABARAPL2

Interactor 2: ATG4A (Q8WYN0)
Cysteine protease ATG4A (EC 3.4.22.-) (AUT-like 2 cysteine endopeptidase) (Autophagy-related cysteine endopeptidase 2) (Autophagin-2) (Autophagy-related protein 4 homolog A) (HsAPG4A) (hAPG4A)
Gene: ATG4A

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	12473658, 17347651
Identification Methods	enzymatic study, protease assay
Interaction Type	direct interaction, cleavage reaction

Property	Details
Interacting Pfam domains	ATG8~Peptidase_C54
Common GO terms	GO:0000045 - autophagosome assembly GO:0005737 - cytoplasm GO:0006914 - autophagy GO:0015031 - protein transport
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 117 Hs			1 398
+	Hs
		306253 GBRAP_HUMAN (1-117): 7.55e-57: 173: 57.27		ATG4A_HUMAN (1-398): 0: 603: 100.00
+	Hs
		1264549 GBRL1_HUMAN (1-116): 7.89e-56: 170: 61.21		ATG4A_HUMAN (1-398): 0: 603: 100.00
+	Hs
		1264550 MLP3A_HUMAN (5-117): 2.01e-45: 144: 41.74		ATG4A_HUMAN (1-398): 0: 603: 100.00
+	Hs
		891370 GBRL2_HUMAN (1-117): 1.08e-58: 178: 100.00		ATG4B_HUMAN (19-398): 0: 546: 54.64
+	Hs
		306368 GBRAP_HUMAN (1-117): 7.55e-57: 173: 57.27		ATG4B_HUMAN (19-398): 0: 546: 54.64
+	Hs
		1328075 GBRL1_HUMAN (1-116): 7.89e-56: 170: 61.21		ATG4B_HUMAN (19-398): 0: 546: 54.64
+	Mm
		1206409 MLP3A_MOUSE (5-117): 2.01e-45: 144: 41.74		ATG4B_MOUSE (19-398): 0: 548: 56.07
+	Hs
		1330686 MLP3A_HUMAN (5-117): 2.01e-45: 144: 41.74		ATG4B_HUMAN (19-398): 0: 546: 54.64
+	Ce
		111920 LGG1_CAEEL (1-116): 2.15e-55: 170: 57.76		ATG41_CAEEL (15-398): 6.27e-163: 467: 38.90
+	Hs
		891203 GBRL2_HUMAN (1-117): 1.08e-58: 178: 100.00		ATG4D_HUMAN (27-358): 1.13e-137: 403: 31.10
+	Hs
		306219 GBRAP_HUMAN (1-117): 7.55e-57: 173: 57.27		ATG4D_HUMAN (27-358): 1.13e-137: 403: 31.10
+	Hs
		1198603 GBRL1_HUMAN (1-116): 7.89e-56: 170: 61.21		ATG4D_HUMAN (27-358): 1.13e-137: 403: 31.10
+	Dm
		1372164 Q9W2S2_DROME (1-117): 5.35e-58: 176: 57.27		Q9VPW2_DROME (20-392): 8.03e-135: 393: 40.58
+	Hs
		306269 GBRAP_HUMAN (1-117): 7.55e-57: 173: 57.27		ATG4C_HUMAN (22-391): 1.6e-132: 389: 26.93
+	Dm
		1179054 Q7K1J3_DROME (1-116): 4.36e-54: 168: 51.72		Q9VPW2_DROME (20-392): 8.03e-135: 393: 40.58
+	Hs
		1288559 GBRL1_HUMAN (1-116): 7.89e-56: 170: 61.21		ATG4C_HUMAN (22-391): 1.6e-132: 389: 26.93
+	Dm
		1364631 Q9VEG5_DROME (1-116): 4.49e-54: 166: 51.72		Q9VPW2_DROME (20-392): 8.03e-135: 393: 40.58
+	Dm
		114224 Q9VEG5_DROME (1-116): 4.49e-54: 166: 51.72		M9PBM3_DROME (20-370): 3.38e-134: 392: 41.85
+	Ce
		999365 LGG1_CAEEL (1-116): 2.15e-55: 170: 57.76		ATG42_CAEEL (13-363): 1.17e-111: 338: 26.36
+	Sc
		746022 ATG8_YEAST (1-116): 1.06e-58: 178: 56.03		ATG4_YEAST (31-342): 1.02e-93: 291: 25.95