Protein: CDK3
Cyclin-dependent kinase 3 (EC 2.7.11.22) (Cell division protein kinase 3)

Gene: CDK3
Organism: Homo sapiens
Interactions: 108
UniProt ID: Q00526

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000307 - cyclin-dependent protein kinase holoenzyme complex
GO:0004693 - cyclin-dependent protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

808021

CDN1A
Cyclin-dependent kinase inhibitor 1

8

20

Small-scale

0.968

High

956646

CKS1
Cyclin-dependent kinases regulatory subunit 1

7

20

Small-scale

0.965

High

753913

CKS2
Cyclin-dependent kinases regulatory subunit 2

5

20

High-throughput

0.926

High

667777

CDK2
Cyclin-dependent kinase 2

5

18

High-throughput

0.925

High

1025251

CDK5
Cyclin-dependent kinase 5

4

17

High-throughput

0.909

High

629100

CCNA2
Cyclin-A2

4

20

High-throughput

0.903

High

666973

CCNE1
G1/S-specific cyclin-E1

4

20

High-throughput

0.903

High

857309

CDN1B
Cyclin-dependent kinase inhibitor 1B

4

20

High-throughput

0.903

High

355344

CCNE2
G1/S-specific cyclin-E2

4

20

Small-scale

0.902

High

461361

HS90A
Heat shock protein HSP 90-alpha

4

18

High-throughput

0.895

High

468267

HS90B
Heat shock protein HSP 90-beta

4

18

High-throughput

0.895

High

666822

CCNC
Cyclin-C

4

20

Small-scale

0.894

High

443308

CDK1
Cyclin-dependent kinase 1

3

18

High-throughput

0.861

High

728578

AKT2
RAC-beta serine/threonine-protein kinase

3

8

High-throughput

0.861

High

892748

CDN1C
Cyclin-dependent kinase inhibitor 1C

3

20

High-throughput

0.861

High

1025261

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

3

8

High-throughput

0.861

High

1025280

SNIP1
Smad nuclear-interacting protein 1

2

1

High-throughput

0.811

High

573801

CCNB1
G2/mitotic-specific cyclin-B1

2

20

Small-scale

0.789

High

718881

CCND3
G1/S-specific cyclin-D3

2

20

High-throughput

0.783

High

908691

CCNH
Cyclin-H

2

20

High-throughput

0.783

High

1025264

CCNI
Cyclin-I

2

20

High-throughput

0.783

High

1025291

RGAP1
Rac GTPase-activating protein 1

2

3

High-throughput

0.783

High

1025268

CDKN3
Cyclin-dependent kinase inhibitor 3

2

2

Small-scale

0.747

High

1025270

H90B4
Putative heat shock protein HSP 90-beta 4

2

18

High-throughput

0.712

High

1025271

HS905
Putative heat shock protein HSP 90-alpha A5

2

20

High-throughput

0.712

High

66882

SPDE4
Speedy protein E4

2

17

High-throughput

0.700

High

1025260

SKP2
S-phase kinase-associated protein 2

4

6

High-throughput

0.699

High

624031

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

11

High-throughput

0.691

High

651125

CCNO
Cyclin-O

1

20

High-throughput

0.691

High

1025258

STK4
Serine/threonine-protein kinase 4

1

12

High-throughput

0.691

High

1025259

STK3
Serine/threonine-protein kinase 3

1

12

High-throughput

0.691

High

284303

GEMI
Geminin

3

2

High-throughput

0.667

High

1025292

CDT1
DNA replication factor Cdt1

3

3

High-throughput

0.667

High

425446

ISG15
Ubiquitin-like protein ISG15

1

8

High-throughput

0.618

High

440029

LCK
Tyrosine-protein kinase Lck

1

12

High-throughput

0.618

High

465487

IGF1R
Insulin-like growth factor 1 receptor

1

17

High-throughput

0.618

High

664708

CCND1
G1/S-specific cyclin-D1

1

20

High-throughput

0.618

High

719130

MPIP1
M-phase inducer phosphatase 1

1

18

High-throughput

0.618

High

719210

MPIP2
M-phase inducer phosphatase 2

1

18

High-throughput

0.618

High

897629

RASF2
Ras association domain-containing protein 2

1

4

High-throughput

0.618

High

1025266

CD5R1
Cyclin-dependent kinase 5 activator 1

1

7

Small-scale

0.618

High

1025267

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

2

High-throughput

0.618

High

1025269

LARP7
La-related protein 7

1

16

High-throughput

0.618

High

1025274

RASF6
Ras association domain-containing protein 6

1

4

High-throughput

0.618

High

1025277

RASF3
Ras association domain-containing protein 3

1

4

High-throughput

0.618

High

1025282

RASF5
Ras association domain-containing protein 5

1

4

High-throughput

0.618

High

1025289

CABL2
CDK5 and ABL1 enzyme substrate 2

1

8

Small-scale

0.618

High

1025296

RASF1
Ras association domain-containing protein 1

1

6

High-throughput

0.618

High

190055

FOXP2
Forkhead box protein P2

2

5

High-throughput

0.606

High

685157

PAX6
Paired box protein Pax-6

2

8

High-throughput

0.606

High

733243

OTX2
Homeobox protein OTX2

2

7

High-throughput

0.606

High

1025255

PAX8
Paired box protein Pax-8

2

9

High-throughput

0.606

High

1025286

LHX4
LIM/homeobox protein Lhx4

2

2

High-throughput

0.606

High

1025293

NELFA
Negative elongation factor A

2

3

High-throughput

0.606

High

1025299

LHX3
LIM/homeobox protein Lhx3

2

3

High-throughput

0.606

High

442669

RB
Retinoblastoma-associated protein

2

10

Small-scale

0.602

High

1025278

CCNQ
Cyclin-Q

1

20

Small-scale

0.590

High

295025

ZN189
Zinc finger protein 189

1

0

High-throughput

0.586

High

971409

1433E
14-3-3 protein epsilon

2

5

High-throughput

0.584

High

1025252

PAX5
Paired box protein Pax-5

2

7

High-throughput

0.553

High

854428

KPB2
Phosphorylase b kinase regulatory subunit alpha, liver isoform

1

1

High-throughput

0.553

High

1025285

KPBB
Phosphorylase b kinase regulatory subunit beta

1

1

High-throughput

0.553

High

1025257

PPARA
Peroxisome proliferator-activated receptor alpha

1

9

High-throughput

0.541

High

536976

HSP7C
Heat shock cognate 71 kDa protein

1

7

High-throughput

0.536

High

731203

STIP1
Stress-induced-phosphoprotein 1

1

4

High-throughput

0.536

High

732543

ARRB2
Beta-arrestin-2

1

1

High-throughput

0.536

High

992136

SKP1
S-phase kinase-associated protein 1

1

4

High-throughput

0.536

High

1025254

EF1A2
Elongation factor 1-alpha 2

1

5

High-throughput

0.536

High

1025262

SNW1
SNW domain-containing protein 1

1

1

High-throughput

0.536

High

1025263

CUL1
Cullin-1

1

6

High-throughput

0.536

High

1025275

CSN6
COP9 signalosome complex subunit 6

1

5

High-throughput

0.536

High

1025284

CSN5
COP9 signalosome complex subunit 5

1

8

High-throughput

0.536

High

1025298

ANFY1
Rabankyrin-5

1

0

High-throughput

0.517

High

1025273

Q6FHY5
MEOX2 protein

1

9

High-throughput

0.515

High

421932

A4
Amyloid-beta precursor protein

1

6

High-throughput

0.501

High

1025288

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

6

High-throughput

0.501

High

893820

MEOX2
Homeobox protein MOX-2

1

9

High-throughput

0.481

High

1025281

FRS2
Fibroblast growth factor receptor substrate 2

1

1

High-throughput

0.481

High

1025287

TRI63
E3 ubiquitin-protein ligase TRIM63

1

10

High-throughput

0.481

High

1025290

TRI55
Tripartite motif-containing protein 55

1

13

High-throughput

0.481

High

324793

HEXI1
Protein HEXIM1

1

5

High-throughput

0.479

High

535930

MYH3
Myosin-3

1

12

High-throughput

0.479

High

556845

MYH1
Myosin-1

1

12

High-throughput

0.479

High

556914

MYH7
Myosin-7

1

12

High-throughput

0.479

High

563005

MYH6
Myosin-6

1

12

High-throughput

0.479

High

563048

MYH8
Myosin-8

1

12

High-throughput

0.479

High

690906

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

729749

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.479

High

730512

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

761368

HS71L
Heat shock 70 kDa protein 1-like

1

7

High-throughput

0.479

High

761637

HSP74
Heat shock 70 kDa protein 4

1

11

High-throughput

0.479

High

1025253

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

1025265

TFDP1
Transcription factor Dp-1

1

7

Small-scale

0.479

High

1025279

SERB1
SERPINE1 mRNA-binding protein 1

1

7

High-throughput

0.479

High

1025294

SAV1
Protein salvador homolog 1

1

9

High-throughput

0.479

High

1025300

MYH2
Myosin-2

1

12

High-throughput

0.479

High

1025301

MYH13
Myosin-13

1

12

High-throughput

0.479

High

1025302

MYH15
Myosin-15

1

12

High-throughput

0.479

High

46798

A0A384NQ31
Epididymis secretory sperm binding protein

1

1

High-throughput

0.470

High

1025295

STN1
CST complex subunit STN1

1

0

High-throughput

0.460

High

1025276

SHLD2
Shieldin complex subunit 2

1

0

High-throughput

0.458

High

397938

ANGI
Angiogenin

1

2

High-throughput

0.445

High

130068

PGRC1
Membrane-associated progesterone receptor component 1

1

4

Small-scale

0.437

High

861121

MAP1B
Microtubule-associated protein 1B

1

7

High-throughput

0.437

High

1025283

RIN2
Ras and Rab interactor 2

1

10

High-throughput

0.437

High

1025297

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

3

0

High-throughput

0.347

High

1025272

OR2G6
Olfactory receptor 2G6

2

0

High-throughput

0.316

High

1025256

NKG2E
NKG2-E type II integral membrane protein

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025