HitPredict

Interactor 1: IL2 (P60568)
Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) (Aldesleukin)
Gene: IL2

Interactor 2: NFAC2 (Q13469)
Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1)
Gene: NFATC2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	20557936, 12560487
Identification Methods	anti tag coimmunoprecipitation, electrophoretic mobility shift assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006366 - transcription by RNA polymerase II GO:0030890 - positive regulation of B cell proliferation
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 153 Hs			1 925
+	Mm
		381344 IL2_MOUSE (1-151): 6.75e-71: 212: 57.23		NFAC2_MOUSE (1-925): 0: 836: 89.13
+	Hs
		891386 IL2_HUMAN (1-153): 1.29e-80: 236: 100.00		NFAC3_HUMAN (25-921): 0: 707: 32.85
+	Hs
		317942 IL2_HUMAN (1-153): 1.29e-80: 236: 100.00		NFAC1_HUMAN (15-923): 0: 630: 41.20
+	Hs
		891381 IL2_HUMAN (1-153): 1.29e-80: 236: 100.00		TF65_HUMAN (394-918): 3.44e-127: 397: 17.89
+	Hs
		891382 IL2_HUMAN (1-153): 1.29e-80: 236: 100.00		REL_HUMAN (408-887): 1.1e-124: 392: 15.77
+	Mm
		381343 IL2_MOUSE (1-151): 6.75e-71: 212: 57.23		TF65_MOUSE (394-918): 6.13e-126: 393: 17.65