Protein: UBE2A
Ubiquitin-conjugating enzyme E2 A (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme A) (RAD6 homolog A) (HR6A) (hHR6A) (Ubiquitin carrier protein A) (Ubiquitin-protein ligase A)

Gene: UBE2A
Organism: Homo sapiens
Interactions: 227
UniProt ID: P49459

Gene Ontology (top 5):
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000209 - protein polyubiquitination
GO:0000785 - chromatin
GO:0004842 - ubiquitin-protein transferase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

884402

RAD18
E3 ubiquitin-protein ligase RAD18

20

6

Small-scale

0.991

High

647502

UBA1
Ubiquitin-like modifier-activating enzyme 1

7

19

Small-scale

0.959

High

884349

BRE1A
E3 ubiquitin-protein ligase BRE1A

6

16

Small-scale

0.950

High

272628

BRE1B
E3 ubiquitin-protein ligase BRE1B

6

16

Small-scale

0.944

High

884291

UBE2A
Ubiquitin-conjugating enzyme E2 A

4

15

Small-scale

0.896

High

884306

UBE2B
Ubiquitin-conjugating enzyme E2 B

3

15

Small-scale

0.861

High

884352

L2GL2
LLGL scribble cell polarity complex component 2

3

1

High-throughput

0.855

High

884355

UBR3
E3 ubiquitin-protein ligase UBR3

3

14

Small-scale

0.850

High

507680

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

3

20

Small-scale

0.834

High

754760

H2B1B
Histone H2B type 1-B

2

8

Small-scale

0.819

High

884318

MDM2
E3 ubiquitin-protein ligase Mdm2

2

13

Small-scale

0.781

High

884359

UBR1
E3 ubiquitin-protein ligase UBR1

2

14

Small-scale

0.775

High

884341

H2B2E
Histone H2B type 2-E

2

8

Small-scale

0.768

High

884346

UBR4
E3 ubiquitin-protein ligase UBR4

2

11

Small-scale

0.743

High

884360

UBR2
E3 ubiquitin-protein ligase UBR2

1

14

Small-scale

0.724

High

413406

P53
Cellular tumor antigen p53

4

3

Small-scale

0.700

High

884315

XIAP
E3 ubiquitin-protein ligase XIAP

1

20

High-throughput

0.691

High

140177

SDCB1
Syntenin-1

3

1

High-throughput

0.675

High

884421

UBQL1
Ubiquilin-1

1

6

High-throughput

0.665

High

241073

PRKN
E3 ubiquitin-protein ligase parkin

1

20

Small-scale

0.647

High

325726

UBR5
E3 ubiquitin-protein ligase UBR5

1

20

Small-scale

0.647

High

550918

PCNA
Proliferating cell nuclear antigen

1

4

Small-scale

0.647

High

884313

RNF4
E3 ubiquitin-protein ligase RNF4

1

20

Small-scale

0.647

High

884333

HLTF
Helicase-like transcription factor

1

10

Small-scale

0.647

High

884345

HECD3
E3 ubiquitin-protein ligase HECTD3

1

20

Small-scale

0.647

High

884398

RN167
E3 ubiquitin-protein ligase RNF167

1

20

Small-scale

0.647

High

224242

BUB3
Mitotic checkpoint protein BUB3

1

5

High-throughput

0.618

High

507116

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

20

High-throughput

0.618

High

884299

H2B1D
Histone H2B type 1-D

1

8

High-throughput

0.618

High

884302

H2B1C
Histone H2B type 1-C/E/F/G/I

1

8

High-throughput

0.618

High

884312

H31
Histone H3.1

1

3

High-throughput

0.618

High

884323

RBBP4
Histone-binding protein RBBP4

1

1

High-throughput

0.618

High

884326

CUL4B
Cullin-4B

1

14

High-throughput

0.618

High

884337

SHPRH
E3 ubiquitin-protein ligase SHPRH

1

8

Small-scale

0.618

High

884350

RN123
E3 ubiquitin-protein ligase RNF123

1

7

High-throughput

0.618

High

884356

H32
Histone H3.2

1

3

High-throughput

0.618

High

884417

HERC5
E3 ISG15--protein ligase HERC5

1

20

Small-scale

0.618

High

884408

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

20

Small-scale

0.586

High

884389

SLF1
SMC5-SMC6 complex localization factor protein 1

2

8

Small-scale

0.584

High

884395

SKI8
Superkiller complex protein 8

1

1

Small-scale

0.575

High

853197

CBX5
Chromobox protein homolog 5

1

3

Small-scale

0.561

High

884294

CDK9
Cyclin-dependent kinase 9

1

3

Small-scale

0.561

High

884340

H2A2C
Histone H2A type 2-C

1

4

High-throughput

0.553

High

884412

ZMYM2
Zinc finger MYM-type protein 2

1

1

Small-scale

0.552

High

571900

TRI27
Zinc finger protein RFP

1

20

High-throughput

0.541

High

884357

TAXB1
Tax1-binding protein 1

1

3

High-throughput

0.536

High

884364

FBXL6
F-box/LRR-repeat protein 6

1

3

High-throughput

0.536

High

884384

Z512B
Zinc finger protein 512B

1

1

High-throughput

0.536

High

884397

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.536

High

337455

PSMG1
Proteasome assembly chaperone 1

1

0

High-throughput

0.518

High

280546

PR40A
Pre-mRNA-processing factor 40 homolog A

1

18

High-throughput

0.515

High

282568

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

1

High-throughput

0.515

High

650087

FGFR3
Fibroblast growth factor receptor 3

1

2

High-throughput

0.515

High

831961

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

2

High-throughput

0.515

High

884296

HSP72
Heat shock-related 70 kDa protein 2

1

1

High-throughput

0.515

High

884303

RAN
GTP-binding nuclear protein Ran

1

1

High-throughput

0.515

High

884381

OPTN
Optineurin

1

3

High-throughput

0.515

High

884410

ATX10
Ataxin-10

1

0

High-throughput

0.513

High

884330

DPYL1
Dihydropyrimidinase-related protein 1

1

1

High-throughput

0.508

High

667644

CDK2
Cyclin-dependent kinase 2

1

2

Small-scale

0.501

High

714791

EF1D
Elongation factor 1-delta

1

1

Small-scale

0.501

High

884347

RC3H1
Roquin-1

1

6

Small-scale

0.501

High

159957

IDLC
Axonemal dynein light intermediate polypeptide 1

1

0

High-throughput

0.493

High

167238

KLF11
Krueppel-like factor 11

1

0

High-throughput

0.493

High

442267

GELS
Gelsolin

1

0

High-throughput

0.493

High

561949

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.493

High

702430

CLAT
Choline O-acetyltransferase

1

0

High-throughput

0.493

High

884297

CASP6
Caspase-6

1

0

High-throughput

0.493

High

884374

RPGF4
Rap guanine nucleotide exchange factor 4

1

0

High-throughput

0.493

High

172049

HNRDL
Heterogeneous nuclear ribonucleoprotein D-like

1

3

High-throughput

0.479

High

173682

BTAF1
TATA-binding protein-associated factor 172

1

1

High-throughput

0.479

High

174722

SPTN2
Spectrin beta chain, non-erythrocytic 2

1

2

High-throughput

0.479

High

207473

DHX15
ATP-dependent RNA helicase DHX15

1

1

High-throughput

0.479

High

210889

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

1

High-throughput

0.479

High

214742

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

1

High-throughput

0.479

High

250506

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

1

High-throughput

0.479

High

251538

CCNT1
Cyclin-T1

1

1

Small-scale

0.479

High

258085

IF2P
Eukaryotic translation initiation factor 5B

1

1

High-throughput

0.479

High

259617

BRD4
Bromodomain-containing protein 4

1

6

High-throughput

0.479

High

262039

NBN
Nibrin

1

2

Small-scale

0.479

High

385068

K1C14
Keratin, type I cytoskeletal 14

1

3

High-throughput

0.479

High

386447

SPTA1
Spectrin alpha chain, erythrocytic 1

1

2

High-throughput

0.479

High

407262

K2C6B
Keratin, type II cytoskeletal 6B

1

1

High-throughput

0.479

High

456656

ANXA2
Annexin A2

1

3

High-throughput

0.479

High

462295

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

1

High-throughput

0.479

High

475544

K1C19
Keratin, type I cytoskeletal 19

1

3

High-throughput

0.479

High

566344

K2C5
Keratin, type II cytoskeletal 5

1

1

High-throughput

0.479

High

567299

TCTP
Translationally-controlled tumor protein

1

3

High-throughput

0.479

High

620204

NUCL
Nucleolin

1

2

High-throughput

0.479

High

650641

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

3

High-throughput

0.479

High

655108

SFPQ
Splicing factor, proline- and glutamine-rich

1

1

High-throughput

0.479

High

684129

DDX6
Probable ATP-dependent RNA helicase DDX6

1

2

High-throughput

0.479

High

684482

CTNA2
Catenin alpha-2

1

1

High-throughput

0.479

High

685449

U2AF2
Splicing factor U2AF 65 kDa subunit

1

2

High-throughput

0.479

High

764277

CTNA1
Catenin alpha-1

1

1

High-throughput

0.479

High

807314

IF4A3
Eukaryotic initiation factor 4A-III

1

2

High-throughput

0.479

High

821259

TCPZ
T-complex protein 1 subunit zeta

1

1

High-throughput

0.479

High

830337

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

884298

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

1

High-throughput

0.479

High

884300

RS15A
Small ribosomal subunit protein uS8

1

1

High-throughput

0.479

High

884311

CSK21
Casein kinase II subunit alpha

1

4

High-throughput

0.479

High

884314

SRSF3
Serine/arginine-rich splicing factor 3

1

1

High-throughput

0.479

High

884317

CDK5
Cyclin-dependent kinase 5

1

2

High-throughput

0.479

High

884319

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.479

High

884325

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

8

High-throughput

0.479

High

884327

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

3

High-throughput

0.479

High

884329

KEAP1
Kelch-like ECH-associated protein 1

1

5

High-throughput

0.479

High

884334

PLSI
Plastin-1

1

2

High-throughput

0.479

High

884338

NONO
Non-POU domain-containing octamer-binding protein

1

2

High-throughput

0.479

High

884342

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

2

High-throughput

0.479

High

884344

TB10B
TBC1 domain family member 10B

1

1

High-throughput

0.479

High

884348

OBSCN
Obscurin

1

5

High-throughput

0.479

High

884353

PKN3
Serine/threonine-protein kinase N3

1

1

High-throughput

0.479

High

884361

PLPL6
Patatin-like phospholipase domain-containing protein 6

1

1

High-throughput

0.479

High

884362

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

1

High-throughput

0.479

High

884369

UBP33
Ubiquitin carboxyl-terminal hydrolase 33

1

6

Small-scale

0.479

High

884371

PDC6I
Programmed cell death 6-interacting protein

1

1

High-throughput

0.479

High

884373

TITIN
Titin

1

1

High-throughput

0.479

High

884375

TCPW
T-complex protein 1 subunit zeta-2

1

1

High-throughput

0.479

High

884378

GCN1
Stalled ribosome sensor GCN1

1

1

High-throughput

0.479

High

884391

WAC
WW domain-containing adapter protein with coiled-coil

1

1

Small-scale

0.479

High

884392

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

3

High-throughput

0.479

High

884399

BRD9
Bromodomain-containing protein 9

1

5

High-throughput

0.479

High

884400

SYSM
Serine--tRNA ligase, mitochondrial

1

1

Small-scale

0.479

High

884401

AAAS
Aladin

1

4

High-throughput

0.479

High

884405

ABHDA
Palmitoyl-protein thioesterase ABHD10, mitochondrial

1

1

Small-scale

0.479

High

884407

ATD3A
ATPase family AAA domain-containing protein 3A

1

2

High-throughput

0.479

High

884414

NPS3A
Protein NipSnap homolog 3A

1

3

Small-scale

0.479

High

884415

TES
Testin

1

1

High-throughput

0.479

High

884418

TNIK
TRAF2 and NCK-interacting protein kinase

1

3

High-throughput

0.479

High

884422

NISCH
Nischarin

1

1

High-throughput

0.479

High

884423

TR150
Thyroid hormone receptor-associated protein 3

1

1

High-throughput

0.479

High

65719

SMHD1
Structural maintenance of chromosomes flexible hinge domain-containing protein 1

1

0

High-throughput

0.458

High

131363

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

0

High-throughput

0.458

High

187668

EIF3D
Eukaryotic translation initiation factor 3 subunit D

1

0

High-throughput

0.458

High

288602

NPM3
Nucleoplasmin-3

1

0

High-throughput

0.458

High

354305

TOM40
Mitochondrial import receptor subunit TOM40 homolog

1

0

High-throughput

0.458

High

459500

PROF1
Profilin-1

1

0

High-throughput

0.458

High

475921

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

0

High-throughput

0.458

High

479779

GSTP1
Glutathione S-transferase P

1

0

High-throughput

0.458

High

518969

RO60
RNA-binding protein RO60

1

0

High-throughput

0.458

High

552772

TPR
Nucleoprotein TPR

1

0

High-throughput

0.458

High

573936

MYL6B
Myosin light chain 6B

1

0

High-throughput

0.458

High

574171

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.458

High

603892

CXA1
Gap junction alpha-1 protein

1

0

High-throughput

0.458

High

651767

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

0

High-throughput

0.458

High

701775

ABCD3
ATP-binding cassette sub-family D member 3

1

0

High-throughput

0.458

High

716786

RL12
Large ribosomal subunit protein uL11

1

0

High-throughput

0.458

High

727724

DNJA1
DnaJ homolog subfamily A member 1

1

0

High-throughput

0.458

High

767133

MERL
Merlin

1

0

High-throughput

0.458

High

788598

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.458

High

842268

RL35
Large ribosomal subunit protein uL29

1

0

High-throughput

0.458

High

842686

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

0

Small-scale

0.458

High

849439

NAMPT
Nicotinamide phosphoribosyltransferase

1

0

High-throughput

0.458

High

860084

RS9
Small ribosomal subunit protein uS4

1

0

High-throughput

0.458

High

884292

MRE11
Double-strand break repair protein MRE11

1

0

High-throughput

0.458

High

884293

EMD
Emerin

1

0

High-throughput

0.458

High

884295

CLCN7
H(+)/Cl(-) exchange transporter 7

1

0

High-throughput

0.458

High

884301

RS23
Small ribosomal subunit protein uS12

1

0

High-throughput

0.458

High

884304

RL23
Large ribosomal subunit protein uL14

1

0

High-throughput

0.458

High

884305

RL10A
Large ribosomal subunit protein uL1

1

0

High-throughput

0.458

High

884307

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

0

High-throughput

0.458

High

884308

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

High-throughput

0.458

High

884309

YBOX1
Y-box-binding protein 1

1

0

High-throughput

0.458

High

884310

TPM4
Tropomyosin alpha-4 chain

1

0

High-throughput

0.458

High

884316

METK1
S-adenosylmethionine synthase isoform type-1

1

0

High-throughput

0.458

High

884331

DCTN1
Dynactin subunit 1

1

0

High-throughput

0.458

High

884335

LBR
Delta(14)-sterol reductase LBR

1

0

High-throughput

0.458

High

884339

ELAV1
ELAV-like protein 1

1

0

High-throughput

0.458

High

884365

ARF
Tumor suppressor ARF

1

0

Small-scale

0.458

High

884370

NU133
Nuclear pore complex protein Nup133

1

0

High-throughput

0.458

High

884376

PSMF1
Proteasome inhibitor PI31 subunit

1

0

High-throughput

0.458

High

884379

ARHG2
Rho guanine nucleotide exchange factor 2

1

0

High-throughput

0.458

High

884386

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

0

High-throughput

0.458

High

884390

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

884394

AP1M1
AP-1 complex subunit mu-1

1

0

High-throughput

0.458

High

884403

SYFB
Phenylalanine--tRNA ligase beta subunit

1

0

High-throughput

0.458

High

884404

OLA1
Obg-like ATPase 1

1

0

High-throughput

0.458

High

884409

SYLC
Leucine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

884411

IKBL1
NF-kappa-B inhibitor-like protein 1

1

0

High-throughput

0.458

High

884413

ZO2
Tight junction protein 2

1

0

High-throughput

0.458

High

884416

PUF60
Poly(U)-binding-splicing factor PUF60

1

0

High-throughput

0.458

High

884419

CPSF3
Cleavage and polyadenylation specificity factor subunit 3

1

0

High-throughput

0.458

High

884425

CD2AP
CD2-associated protein

1

0

High-throughput

0.458

High

702420

PEX2
Peroxisome biogenesis factor 2

1

2

Small-scale

0.445

High

884351

CDC73
Parafibromin

1

2

Small-scale

0.445

High

884354

CTR9
RNA polymerase-associated protein CTR9 homolog

1

3

Small-scale

0.445

High

884372

LEO1
RNA polymerase-associated protein LEO1

1

3

Small-scale

0.445

High

884377

RTF1
RNA polymerase-associated protein RTF1 homolog

1

2

Small-scale

0.445

High

884388

KLDC3
Kelch domain-containing protein 3

1

6

High-throughput

0.445

High

168209

HAT1
Histone acetyltransferase type B catalytic subunit

1

0

High-throughput

0.438

High

884406

EKI2
Ethanolamine kinase 2

1

0

High-throughput

0.438

High

466011

ANXA6
Annexin A6

1

3

High-throughput

0.437

High

615348

SON
Protein SON

1

1

High-throughput

0.437

High

884320

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

Small-scale

0.437

High

884321

LG3BP
Galectin-3-binding protein

1

6

High-throughput

0.437

High

884343

RA1L2
Heterogeneous nuclear ribonucleoprotein A1-like 2

1

3

High-throughput

0.437

High

884380

LRC59
Leucine-rich repeat-containing protein 59

1

3

High-throughput

0.437

High

884382

CPNE2
Copine-2

1

4

High-throughput

0.437

High

884387

NIPS1
Protein NipSnap homolog 1

1

3

Small-scale

0.437

High

884420

F184B
Protein FAM184B

1

2

High-throughput

0.437

High

884424

ACOT9
Acyl-coenzyme A thioesterase 9, mitochondrial

1

1

Small-scale

0.437

High

884322

ECHP
Peroxisomal bifunctional enzyme

1

0

High-throughput

0.426

High

774206

BASI
Basigin

1

1

High-throughput

0.417

High

884383

JPH4
Junctophilin-4

2

0

High-throughput

0.328

High

569174

CD59
CD59 glycoprotein

2

0

High-throughput

0.318

High

294842

BCAR3
Breast cancer anti-estrogen resistance protein 3

1

0

High-throughput

0.279

Low

884358

RETR3
Reticulophagy regulator 3

1

0

High-throughput

0.279

Low

719880

HMOX2
Heme oxygenase 2

1

0

High-throughput

0.268

Low

884324

Q0VDC6
peptidylprolyl isomerase

1

0

High-throughput

0.268

Low

884336

NMDE3
Glutamate receptor ionotropic, NMDA 2C

1

0

High-throughput

0.268

Low

884393

NUP58
Nucleoporin p58/p45

1

0

High-throughput

0.268

Low

884426

Q9Y649
GW128

1

0

High-throughput

0.268

Low

338078

NSA2
Ribosome biogenesis protein NSA2 homolog

1

0

High-throughput

0.249

Low

483538

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

0

High-throughput

0.249

Low

506412

ONCO
Oncomodulin-1

1

0

High-throughput

0.249

Low

666268

THIL
Acetyl-CoA acetyltransferase, mitochondrial

1

0

High-throughput

0.249

Low

762222

TRY3
Trypsin-3

1

0

High-throughput

0.249

Low

884328

DSG2
Desmoglein-2

1

0

High-throughput

0.249

Low

884332

FLOT2
Flotillin-2

1

0

High-throughput

0.249

Low

884363

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

0

High-throughput

0.249

Low

884367

FA98A
Protein FAM98A

1

0

High-throughput

0.249

Low

884385

DOCK7
Dedicator of cytokinesis protein 7

1

0

High-throughput

0.249

Low

884396

CPVL
Probable serine carboxypeptidase CPVL

1

0

High-throughput

0.249

Low

884368

CKLF2
CKLF-like MARVEL transmembrane domain-containing protein 2

1

0

High-throughput

0.238

Low

884366

SYT2
Synaptotagmin-2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025