HitPredict

Interactor 1: UB2G2 (P60604)
Ubiquitin-conjugating enzyme E2 G2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme G2) (Ubiquitin carrier protein G2) (Ubiquitin-protein ligase G2)
Gene: UBE2G2

Interactor 2: AMFR (Q9UKV5)
E3 ubiquitin-protein ligase AMFR (EC 2.3.2.36) (Autocrine motility factor receptor) (AMF receptor) (RING finger protein 45) (gp78)
Gene: AMFR

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.988

The method score is based on:

Property Details
Experiments 17353931, 28434917, 32333192, 16407162, 19223579, 25409783, 24366945, 22119785, 24424410, 28884161, 32614325, 17681147, 21636303, 23223569, 18216283, 23942235, 24496447
Identification Methods affinity chromatography technology, pull down, unspecified method, x-ray crystallography, enzymatic study, anti tag coimmunoprecipitation, nuclear magnetic resonance, anti bait coimmunoprecipitation, surface plasmon resonance, x ray scattering
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains G2BR~UQ_con, UQ_con~zf-RING_2
Common GO terms GO:0004842 - ubiquitin-protein transferase activity
GO:0005783 - endoplasmic reticulum
GO:0005829 - cytosol
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0036503 - ERAD pathway
and 1 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Last updated: 15 Jul 2024