Protein: MCK1
Protein kinase MCK1 (EC 2.7.12.1) (Meiosis and centromere regulatory kinase)

Gene: MCK1
Organism: Saccharomyces cerevisiae S288C
Interactions: 214
UniProt ID: P21965

Gene Ontology (top 5):
GO:0000070 - mitotic sister chromatid segregation
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004712 - protein serine/threonine/tyrosine kinase activity
GO:0004713 - protein tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

642325

MPIP
M-phase inducer phosphatase

2

5

Small-scale

0.768

High

642319

MCK1
Protein kinase MCK1

2

17

Small-scale

0.757

High

392230

HSP82
ATP-dependent molecular chaperone HSP82

2

14

High-throughput

0.754

High

578851

HSC82
ATP-dependent molecular chaperone HSC82

2

14

High-throughput

0.754

High

642363

NNK1
Nitrogen network kinase 1

1

11

High-throughput

0.691

High

642440

NOP15
Ribosome biogenesis protein 15

1

9

High-throughput

0.691

High

642447

CDC14
Tyrosine-protein phosphatase CDC14

1

3

High-throughput

0.691

High

642321

RAD53
Serine/threonine-protein kinase RAD53

1

9

Small-scale

0.680

High

597382

EF3A
Elongation factor 3A

1

2

High-throughput

0.647

High

636449

ACE2
Metallothionein expression activator

1

8

High-throughput

0.647

High

642336

KCC1
Calcium/calmodulin-dependent protein kinase I

1

7

High-throughput

0.647

High

642338

CDC15
Cell division control protein 15

1

20

High-throughput

0.647

High

642358

HSL1
Probable serine/threonine-protein kinase HSL1

1

15

Small-scale

0.647

High

642361

PP2C1
Protein phosphatase 2C homolog 1

1

8

High-throughput

0.647

High

642364

KKQ8
Probable serine/threonine-protein kinase KKQ8

1

19

High-throughput

0.647

High

642409

GCN20
Protein GCN20

1

1

High-throughput

0.647

High

642412

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.647

High

642428

PCL10
PHO85 cyclin-10

1

8

High-throughput

0.647

High

642436

FPK1
Flippase kinase 1

1

20

High-throughput

0.647

High

642445

CRZ1
Transcriptional regulator CRZ1

1

2

High-throughput

0.647

High

642493

CMR3
Zinc finger protein CRM3

1

1

High-throughput

0.647

High

642380

KSP1
Serine/threonine-protein kinase KSP1

1

20

High-throughput

0.646

High

479248

CDC6
Cell division control protein 6

2

4

Small-scale

0.636

High

642327

CG22
G2/mitotic-specific cyclin-2

1

20

Small-scale

0.618

High

642329

SIS1
Protein SIS1

1

4

High-throughput

0.618

High

642442

APJ1
J domain-containing protein APJ1

1

3

High-throughput

0.618

High

642342

BMH1
Protein BMH1

2

5

High-throughput

0.594

High

642503

PEX11
Peroxisomal membrane protein PMP27

2

0

High-throughput

0.587

High

625938

UBR1
E3 ubiquitin-protein ligase UBR1

1

2

Small-scale

0.586

High

642354

CBF3A
Centromere DNA-binding protein complex CBF3 subunit A

2

0

Small-scale

0.579

High

642470

RRP5
rRNA biogenesis protein RRP5

1

4

High-throughput

0.579

High

642488

CWC2
Pre-mRNA-splicing factor CWC2

1

5

High-throughput

0.579

High

364926

KPYK1
Pyruvate kinase 1

1

4

Small-scale

0.573

High

533158

GPA2
Guanine nucleotide-binding protein alpha-2 subunit

1

1

Small-scale

0.561

High

642477

RGA2
Rho-type GTPase-activating protein 2

2

11

High-throughput

0.558

High

525925

HSP72
Heat shock protein SSA2

2

9

High-throughput

0.552

High

642464

MYO5
Myosin-5

1

16

High-throughput

0.541

High

416860

CDC25
Cell division control protein 25

1

3

High-throughput

0.536

High

642323

URE2
Transcriptional regulator URE2

1

1

High-throughput

0.536

High

642356

PMD1
Negative regulator of sporulation PMD1

1

2

High-throughput

0.536

High

642401

SLM1
Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1

1

2

High-throughput

0.536

High

642422

ASK10
Activator of SKN7 protein 10

1

2

High-throughput

0.536

High

642426

MDS3
Negative regulator of sporulation MDS3

1

2

High-throughput

0.536

High

642456

YE11B
Transposon Ty1-ER1 Gag-Pol polyprotein

1

8

High-throughput

0.536

High

642472

RGC1
Regulator of the glycerol channel 1

1

2

High-throughput

0.536

High

642482

TRM3
tRNA

1

1

High-throughput

0.536

High

642485

LAM6
Membrane-anchored lipid-binding protein LAM6

1

2

High-throughput

0.536

High

642495

PSH1
RING finger protein PSH1

1

3

High-throughput

0.536

High

642497

YB21A
Transposon Ty2-B Gag polyprotein

1

12

High-throughput

0.536

High

642411

ECO1
N-acetyltransferase ECO1

1

0

Small-scale

0.527

High

642320

SNF2
Transcription regulatory protein SNF2

1

6

High-throughput

0.515

High

642431

MCY1
Putative mitochondrial cysteine synthase

1

1

High-throughput

0.515

High

642432

RSC1
Chromatin structure-remodeling complex subunit RSC1

1

7

High-throughput

0.515

High

642370

SEA4
SEH-associated protein 4

1

0

High-throughput

0.513

High

642381

NPR3
Nitrogen permease regulator 3

1

0

High-throughput

0.513

High

642385

UME6
Transcriptional regulatory protein UME6

1

1

Small-scale

0.508

High

455543

SYSC
Serine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.501

High

514989

YE11A
Transposon Ty1-ER1 Gag polyprotein

1

11

High-throughput

0.501

High

598951

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

3

High-throughput

0.501

High

642322

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

4

High-throughput

0.501

High

642326

SSD1
Protein SSD1

1

1

High-throughput

0.501

High

642328

PTP1
Tyrosine-protein phosphatase 1

1

4

High-throughput

0.501

High

642337

GYS2
Glycogen [starch] synthase isoform 2

1

3

High-throughput

0.501

High

642340

KIP2
Kinesin-like protein KIP2

1

7

Small-scale

0.501

High

642343

MCM2
DNA replication licensing factor MCM2

1

7

High-throughput

0.501

High

642347

MLF3
Protein MLF3

1

2

High-throughput

0.501

High

642355

PAH1
Phosphatidic acid phosphohydrolase 1

1

2

High-throughput

0.501

High

642367

ADCS
Aminodeoxychorismate synthase

1

4

High-throughput

0.501

High

642372

NCL1
Multisite-specific tRNA:(cytosine-C(5))-methyltransferase

1

1

High-throughput

0.501

High

642393

UBP9
Ubiquitin carboxyl-terminal hydrolase 9

1

2

High-throughput

0.501

High

642394

EDC3
Enhancer of mRNA-decapping protein 3

1

2

High-throughput

0.501

High

642399

VHS2
Protein VHS2

1

2

High-throughput

0.501

High

642402

SYA
Alanine--tRNA ligase, mitochondrial

1

3

High-throughput

0.501

High

642403

YAP4
AP-1-like transcription factor YAP4

1

1

High-throughput

0.501

High

642405

YRB1
Ran-specific GTPase-activating protein 1

1

4

High-throughput

0.501

High

642407

GZF3
Protein GZF3

1

4

High-throughput

0.501

High

642410

ROG3
Protein ROG3

1

3

High-throughput

0.501

High

642413

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

3

High-throughput

0.501

High

642415

ALY2
Arrestin-related trafficking adapter 3

1

4

High-throughput

0.501

High

642441

NIS1
Protein NIS1

1

1

High-throughput

0.501

High

642443

AQR1
Probable transporter AQR1

1

2

High-throughput

0.501

High

642450

RNT1
Ribonuclease 3

1

3

High-throughput

0.501

High

642454

NHP10
Non-histone protein 10

1

6

High-throughput

0.501

High

642460

YAP6
AP-1-like transcription factor YAP6

1

1

High-throughput

0.501

High

642468

YM11A
Transposon Ty1-ML1 Gag polyprotein

1

11

High-throughput

0.501

High

642480

BDF2
Bromodomain-containing factor 2

1

6

High-throughput

0.501

High

642483

RIX7
Ribosome biogenesis ATPase RIX7

1

6

High-throughput

0.501

High

642499

TRM13
tRNA:m(4)X modification enzyme TRM13

1

1

High-throughput

0.501

High

642501

YN11A
Transposon Ty1-NL1 Gag polyprotein

1

11

High-throughput

0.501

High

642504

YG12A
Transposon Ty1-GR2 Gag polyprotein

1

11

High-throughput

0.501

High

642505

CMR1
DNA damage-binding protein CMR1

1

3

High-throughput

0.501

High

642360

BMH2
Protein BMH2

1

5

High-throughput

0.500

High

642330

PRTD
Saccharolysin

1

0

High-throughput

0.493

High

571025

CHS2
Chitin synthase 2

1

1

High-throughput

0.489

High

642362

MNR2
Manganese resistance protein MNR2

1

1

High-throughput

0.489

High

642400

PRM5
Pheromone-regulated membrane protein 5

1

1

High-throughput

0.489

High

642420

IML1
Vacuolar membrane-associated protein IML1

1

1

High-throughput

0.489

High

642425

SEH1
Nucleoporin SEH1

1

6

High-throughput

0.489

High

642444

YNF8
Vacuolar membrane protein YNL058C

1

1

High-throughput

0.489

High

642459

WDR59
Maintenance of telomere capping protein 5

1

7

High-throughput

0.489

High

642466

SEC13
Protein transport protein SEC13

1

4

High-throughput

0.489

High

642486

ALR1
Magnesium transporter ALR1

1

1

High-throughput

0.489

High

642487

RTC1
Restriction of telomere capping protein 1

1

9

High-throughput

0.489

High

439558

LEU1
2-isopropylmalate synthase

1

0

High-throughput

0.480

High

582221

AMPD
AMP deaminase

1

0

High-throughput

0.480

High

632301

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.480

High

642332

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

0

Small-scale

0.480

High

642339

FUN19
SWIRM domain-containing protein FUN19

1

0

High-throughput

0.480

High

642359

SLD2
DNA replication regulator SLD2

1

0

Small-scale

0.480

High

642368

SOL2
6-phosphogluconolactonase-like protein 2

1

0

High-throughput

0.480

High

642386

CAT8
Regulatory protein CAT8

1

0

High-throughput

0.480

High

642390

MTW1
Kinetochore-associated protein MTW1

1

0

High-throughput

0.480

High

642396

PPN2
Zinc-dependent endopolyphosphatase

1

0

High-throughput

0.480

High

642397

PP4R3
Serine/threonine-protein phosphatase 4 regulatory subunit 3

1

0

High-throughput

0.480

High

642418

DPOD3
DNA polymerase delta subunit 3

1

0

High-throughput

0.480

High

642419

EFM3
Protein-lysine N-methyltransferase EFM3

1

0

High-throughput

0.480

High

642421

YJ9I
Uncharacterized protein YJR141W

1

0

High-throughput

0.480

High

642430

EFM5
Protein-lysine N-methyltransferase EFM5

1

0

High-throughput

0.480

High

642433

YG36
Uncharacterized protein YGR126W

1

0

High-throughput

0.480

High

642434

REXO1
RNA exonuclease 1

1

0

High-throughput

0.480

High

642437

DUS1
tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]

1

0

High-throughput

0.480

High

642439

SWT21
Protein SWT21

1

0

High-throughput

0.480

High

642453

ADD37
Alpha1-proteinase inhibitor-degradation deficient protein 37

1

0

High-throughput

0.480

High

642465

MGR3
Mitochondrial inner membrane i-AAA protease supercomplex subunit MGR3

1

0

High-throughput

0.480

High

642469

SML1
Ribonucleotide reductase inhibitor protein SML1

1

0

High-throughput

0.480

High

642478

UBX5
UBX domain-containing protein 5

1

0

High-throughput

0.480

High

642479

SSK1
Osmolarity two-component system protein SSK1

1

0

High-throughput

0.480

High

642489

KAD6
Adenylate kinase isoenzyme 6 homolog FAP7

1

0

High-throughput

0.480

High

642491

SAS10
Something about silencing protein 10

1

0

High-throughput

0.480

High

642496

USB1
U6 snRNA phosphodiesterase 1

1

0

High-throughput

0.480

High

642502

MPC70
Sporulation-specific protein 21

1

0

High-throughput

0.480

High

434827

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

642333

RS2
Small ribosomal subunit protein uS5

1

3

High-throughput

0.479

High

642335

CDC48
Cell division control protein 48

1

6

High-throughput

0.479

High

642341

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

642346

HS104
Heat shock protein 104

1

2

High-throughput

0.479

High

642365

CENPA
Histone H3-like centromeric protein CSE4

1

2

Small-scale

0.479

High

642371

ATG8
Autophagy-related protein 8

1

1

High-throughput

0.479

High

642438

GIS2
Zinc finger protein GIS2

1

1

High-throughput

0.479

High

642457

YE12B
Transposon Ty1-ER2 Gag-Pol polyprotein

1

9

High-throughput

0.479

High

642461

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.479

High

642463

PDS5
Sister chromatid cohesion protein PDS5

1

1

High-throughput

0.479

High

642473

IMB1
Importin subunit beta-1

1

6

High-throughput

0.479

High

642481

SUB2
ATP-dependent RNA helicase SUB2

1

11

High-throughput

0.479

High

642494

SCC1
Sister chromatid cohesion protein 1

1

1

High-throughput

0.479

High

642500

DBP10
ATP-dependent RNA helicase DBP10

1

11

High-throughput

0.479

High

642404

HUL4
Probable E3 ubiquitin-protein ligase HUL4

1

4

High-throughput

0.470

High

558584

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.458

High

642452

ESP1
Separin

1

0

High-throughput

0.458

High

642462

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

642474

NHEJ1
Non-homologous end-joining protein 1

1

0

Small-scale

0.458

High

642475

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

642476

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

600649

SEC2
Rab guanine nucleotide exchange factor SEC2

1

1

High-throughput

0.457

High

642324

MBR1
Mitochondrial biogenesis regulation protein 1

1

1

High-throughput

0.457

High

642334

YCZ0
Uncharacterized protein YCR100C

1

1

High-throughput

0.457

High

642345

RM09
Large ribosomal subunit protein uL3m

1

1

High-throughput

0.457

High

642348

YMC1
Mitochondrial glycine transporter YMC1

1

4

High-throughput

0.457

High

642349

CDC11
Cell division control protein 11

1

2

High-throughput

0.457

High

642350

EUG1
Protein disulfide-isomerase EUG1

1

6

High-throughput

0.457

High

642369

AP2A
AP-2 complex subunit alpha

1

5

High-throughput

0.457

High

642373

QDR3
Quinidine resistance protein 3

1

2

High-throughput

0.457

High

642375

AIM3
Altered inheritance of mitochondria protein 3

1

5

High-throughput

0.457

High

642377

UBX7
UBX domain-containing protein 7

1

5

High-throughput

0.457

High

642379

GLO3
ADP-ribosylation factor GTPase-activating protein GLO3

1

8

High-throughput

0.457

High

642384

GGC1
Mitochondrial GTP/GDP carrier protein 1

1

6

High-throughput

0.457

High

642389

ERP2
Protein ERP2

1

4

High-throughput

0.457

High

642391

HPH2
Protein HPH2

1

1

High-throughput

0.457

High

642398

VPS27
Vacuolar protein sorting-associated protein 27

1

5

High-throughput

0.457

High

642446

TMEDA
Endoplasmic reticulum vesicle protein 25

1

3

High-throughput

0.457

High

642451

YP077
Uncharacterized protein YPL077C

1

1

High-throughput

0.457

High

642448

UBC7
Ubiquitin-conjugating enzyme E2 7

1

3

High-throughput

0.457

High

523061

HSP71
Heat shock protein SSA1

1

9

High-throughput

0.445

High

642395

SSB2
Ribosome-associated molecular chaperone SSB2

1

11

High-throughput

0.445

High

642406

MPG1
Mannose-1-phosphate guanyltransferase

1

2

High-throughput

0.445

High

642490

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

9

High-throughput

0.445

High

642388

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

642449

MLP1
Protein MLP1

1

14

High-throughput

0.437

High

642467

POB3
FACT complex subunit POB3

1

1

High-throughput

0.437

High

642387

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.426

High

642417

NOP9
Nucleolar protein 9

1

0

High-throughput

0.426

High

642376

YB75
Uncharacterized protein YBR225W

2

0

High-throughput

0.322

High

642344

ITR1
Myo-inositol transporter 1

1

0

High-throughput

0.279

Low

642352

KRE6
Beta-glucan synthesis-associated protein KRE6

1

0

High-throughput

0.279

Low

642378

FKS1
1,3-beta-glucan synthase component FKS1

1

0

High-throughput

0.279

Low

642383

PNT1
Pentamidine resistance factor, mitochondrial

1

0

High-throughput

0.279

Low

642392

NPR2
Nitrogen permease regulator 2

1

0

High-throughput

0.279

Low

642416

NET1
Nucleolar protein NET1

1

0

High-throughput

0.279

Low

642455

YM8V
Uncharacterized protein YMR295C

1

0

High-throughput

0.279

Low

642498

ATG34
Autophagy-related protein 34

1

0

High-throughput

0.279

Low

598565

RGP1
Guanine nucleotide exchange factor subunit RGP1

1

0

High-throughput

0.269

Low

642353

EI2BB
Translation initiation factor eIF2B subunit beta

1

0

High-throughput

0.265

Low

150364

YP089
Dilute domain-containing protein YPR089W

1

0

High-throughput

0.261

Low

518708

ADH4
Alcohol dehydrogenase 4

1

0

High-throughput

0.261

Low

642331

ADH7
NADP-dependent alcohol dehydrogenase 7

1

0

High-throughput

0.261

Low

642357

GPT1
Glycerol-3-phosphate O-acyltransferase 1

1

0

High-throughput

0.261

Low

642366

AVT3
Vacuolar amino acid transporter 3

1

0

High-throughput

0.261

Low

642374

IST2
Increased sodium tolerance protein 2

1

0

High-throughput

0.261

Low

642382

IPT1
Inositolphosphotransferase 1

1

0

High-throughput

0.261

Low

642408

PRM10
Pheromone-regulated membrane protein 10

1

0

High-throughput

0.261

Low

642414

STB2
Protein STB2

1

0

High-throughput

0.261

Low

642423

YD186
Uncharacterized protein YDL186W

1

0

High-throughput

0.261

Low

642427

TPN1
Vitamin B6 transporter TPN1

1

0

High-throughput

0.261

Low

642429

MST27
Multicopy suppressor of SEC21 protein 27

1

0

High-throughput

0.261

Low

642435

SUN4
Probable secreted beta-glucosidase SUN4

1

0

High-throughput

0.261

Low

642458

YMD7
Uncharacterized protein YML037C

1

0

High-throughput

0.261

Low

642471

DFG5
Mannan endo-1,6-alpha-mannosidase DFG5

1

0

High-throughput

0.261

Low

642484

YL030
Putative uncharacterized protein YLR030W

1

0

High-throughput

0.261

Low

642492

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.261

Low

642506

VCX1
Vacuolar calcium ion transporter

1

0

High-throughput

0.261

Low

642424

SC6B1
Protein transport protein SBH1

1

0

Small-scale

0.251

Low

94534

STE2
Pheromone alpha factor receptor

1

0

High-throughput

0.249

Low

642351

ERG1
Squalene epoxidase ERG1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025