HitPredict

Interactor 1: ACTB (P60709)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Interactor 2: WDR5 (P61964)
WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)
Gene: WDR5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	33022573, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0045893 - positive regulation of DNA-templated transcription GO:0051726 - regulation of cell cycle
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 375 Hs			1 334
+	Hs
		903316 POTEE_HUMAN (1-375): 0: 736: 92.00		WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00
+	Hs
		903280 ACTBL_HUMAN (2-375): 0: 735: 91.71		WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00
+	Hs
		903110 ACTG_HUMAN (1-375): 0: 601: 98.93		WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00
+	Hs
		792947 ACTB_HUMAN (1-375): 0: 603: 100.00		LIS1_HUMAN (2-289): 1.55e-94: 288: 29.49
+	Hs
		792968 ACTG_HUMAN (1-375): 0: 601: 98.93		LIS1_HUMAN (2-289): 1.55e-94: 288: 29.49
+	Hs
		932189 ACTC_HUMAN (2-375): 0: 592: 94.12		SMU1_HUMAN (30-331): 7.66e-39: 145: 28.71
+	Hs
		932318 ACTC_HUMAN (2-375): 0: 592: 94.12		SNR40_HUMAN (248-333): 6.9e-13: 70.4: 25.29
+	Hs
		196998 ACTC_HUMAN (2-375): 0: 592: 94.12		PRP4_HUMAN (244-333): 1.12e-10: 64.2: 19.39