Protein: EST1A
Telomerase-binding protein EST1A (EC 3.1.-.-) (Ever shorter telomeres 1A) (hEST1A) (Nonsense mediated mRNA decay factor SMG6) (Smg-6 homolog) (hSmg5/7a)

Gene: EST1A, SMG6
Organism: Homo sapiens
Interactions: 77
UniProt ID: Q86US8

Gene Ontology (top 5):
GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000781 - chromosome, telomeric region
GO:0003723 - RNA binding
GO:0004521 - RNA endonuclease activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1200048

SMG7
Nonsense-mediated mRNA decay factor SMG7

2

4

Small-scale

0.754

High

1200073

SMG5
Nonsense-mediated mRNA decay factor SMG5

2

4

Small-scale

0.754

High

1200049

RENT1
Regulator of nonsense transcripts 1

3

6

Small-scale

0.656

High

154033

TERT
Telomerase reverse transcriptase

2

1

Small-scale

0.624

High

1200042

EST1A
Telomerase-binding protein EST1A

1

4

Small-scale

0.618

High

1200056

LPIN3
Phosphatidate phosphatase LPIN3

2

0

High-throughput

0.602

High

1200066

HAOX2
2-Hydroxyacid oxidase 2

2

0

High-throughput

0.602

High

931710

CSK2B
Casein kinase II subunit beta

2

0

High-throughput

0.585

High

369924

ESR1
Estrogen receptor

2

0

High-throughput

0.547

High

818206

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.536

High

718966

PHB1
Prohibitin 1

1

1

High-throughput

0.515

High

1151095

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.515

High

851567

NEK4
Serine/threonine-protein kinase Nek4

1

0

High-throughput

0.513

High

887573

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.513

High

1200074

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

0

High-throughput

0.513

High

124428

HIP1
Huntingtin-interacting protein 1

1

0

High-throughput

0.493

High

263706

PR40A
Pre-mRNA-processing factor 40 homolog A

1

0

High-throughput

0.493

High

877081

CASP6
Caspase-6

1

0

High-throughput

0.493

High

919143

RAN
GTP-binding nuclear protein Ran

1

0

High-throughput

0.493

High

737900

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

0

Small-scale

0.486

High

838091

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.481

High

61403

CNOT1
CCR4-NOT transcription complex subunit 1

1

1

High-throughput

0.479

High

243481

DNJA2
DnaJ homolog subfamily A member 2

1

1

High-throughput

0.479

High

257373

CNOT3
CCR4-NOT transcription complex subunit 3

1

5

High-throughput

0.479

High

272623

OFD1
Centriole and centriolar satellite protein OFD1

1

1

High-throughput

0.479

High

321588

AP2A1
AP-2 complex subunit alpha-1

1

1

High-throughput

0.479

High

328889

TOP3B
DNA topoisomerase 3-beta-1

1

1

High-throughput

0.479

High

516578

PABP1
Polyadenylate-binding protein 1

1

1

Small-scale

0.479

High

681513

DNJA1
DnaJ homolog subfamily A member 1

1

1

High-throughput

0.479

High

820963

PRC2A
Protein PRRC2A

1

8

High-throughput

0.479

High

843773

FXR1
RNA-binding protein FXR1

1

6

High-throughput

0.479

High

1127638

PRC2B
Protein PRRC2B

1

6

High-throughput

0.479

High

1192318

YTHD3
YTH domain-containing family protein 3

1

6

High-throughput

0.479

High

1200043

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

3

High-throughput

0.479

High

1200045

XRN1
5'-3' exoribonuclease 1

1

3

High-throughput

0.479

High

1200050

ASPP1
Apoptosis-stimulating of p53 protein 1

1

5

High-throughput

0.479

High

1200052

SMG1
Serine/threonine-protein kinase SMG1

1

1

High-throughput

0.479

High

1200055

ATX2
Ataxin-2

1

1

High-throughput

0.479

High

1200057

HDAC8
Histone deacetylase 8

1

2

Small-scale

0.479

High

1200058

REN3B
Regulator of nonsense transcripts 3B

1

2

Small-scale

0.479

High

1200059

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

1200060

TDRD3
Tudor domain-containing protein 3

1

2

High-throughput

0.479

High

1200062

RC3H2
Roquin-2

1

6

High-throughput

0.479

High

1200065

4ET
Eukaryotic translation initiation factor 4E transporter

1

2

High-throughput

0.479

High

1200070

AGO2
Protein argonaute-2

1

2

High-throughput

0.479

High

1200071

AGO1
Protein argonaute-1

1

2

High-throughput

0.479

High

1200075

PRC2C
Protein PRRC2C

1

7

High-throughput

0.479

High

1200076

YTHD2
YTH domain-containing family protein 2

1

6

High-throughput

0.479

High

1200077

RBM8A
RNA-binding protein 8A

1

4

Small-scale

0.479

High

118881

GTPB1
GTP-binding protein 1

1

0

High-throughput

0.458

High

308846

KI20A
Kinesin-like protein KIF20A

1

0

High-throughput

0.458

High

379568

MYCN
N-myc proto-oncogene protein

1

0

High-throughput

0.458

High

506616

BCR
Breakpoint cluster region protein

1

0

High-throughput

0.458

High

899514

MGN
Protein mago nashi homolog

1

0

Small-scale

0.458

High

941999

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

1

0

High-throughput

0.458

High

1093016

CSPP1
Centrosome and spindle pole-associated protein 1

1

0

High-throughput

0.458

High

1200044

RTKN2
Rhotekin-2

1

0

High-throughput

0.458

High

1200047

BRX1
Ribosome biogenesis protein BRX1 homolog

1

0

High-throughput

0.458

High

1200053

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.458

High

1200061

UCK1
Uridine-cytidine kinase 1

1

0

High-throughput

0.458

High

1200063

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

0

High-throughput

0.458

High

1200064

Q9HCK3
KIAA1569 protein

1

0

High-throughput

0.458

High

1200068

IBTK
Inhibitor of Bruton tyrosine kinase

1

0

High-throughput

0.458

High

1200069

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1200072

CP131
Centrosomal protein of 131 kDa

1

0

High-throughput

0.458

High

717981

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.445

High

1200051

CC138
Coiled-coil domain-containing protein 138

1

1

High-throughput

0.437

High

1027095

CBX3
Chromobox protein homolog 3

1

0

Small-scale

0.426

High

509872

PSG1
Pregnancy-specific beta-1-glycoprotein 1

3

0

High-throughput

0.347

High

1102078

CB068
UPF0561 protein C2orf68

3

0

High-throughput

0.347

High

61788

F221B
Protein FAM221B

2

0

High-throughput

0.328

High

1139292

SPAT1
Spermatogenesis-associated protein 1

1

0

High-throughput

0.279

Low

1200046

CT197
Putative uncharacterized protein encoded by LINC02910

1

0

High-throughput

0.279

Low

1200067

PEN2
Gamma-secretase subunit PEN-2

1

0

High-throughput

0.279

Low

527573

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.268

Low

1200054

MPP9
M-phase phosphoprotein 9

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024