HitPredict

Interactor 1: ACTB (P60709)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Interactor 2: CAP1 (Q01518)
Adenylyl cyclase-associated protein 1 (CAP 1)
Gene: CAP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.927

Property	Details
Experiments	28514442, 33961781, 34079125, 35271311, 37071682
Identification Methods	affinity chromatography technology, proximity labelling technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~CAP_C
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0007163 - establishment or maintenance of cell polarity GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 375 Hs			1 475
+	Hs
		965194 ACTBL_HUMAN (2-375): 0: 735: 91.71		CAP1_HUMAN (1-475): 0: 711: 100.00
+	Hs
		474807 POTEI_HUMAN (1-375): 0: 731: 91.20		CAP1_HUMAN (1-475): 0: 711: 100.00
+	Hs
		768478 ACTBL_HUMAN (2-375): 0: 735: 91.71		CAP2_HUMAN (1-473): 0: 647: 63.05
+	Hs
		474796 POTEI_HUMAN (1-375): 0: 731: 91.20		CAP2_HUMAN (1-473): 0: 647: 63.05
+	Hs
		929826 ACTG_HUMAN (1-375): 0: 601: 98.93		CAP1_HUMAN (1-475): 0: 711: 100.00
+	Hs
		932956 ACTS_HUMAN (2-375): 0: 592: 93.58		CAP1_HUMAN (1-475): 0: 711: 100.00
+	Hs
		768462 ACTB_HUMAN (1-375): 0: 603: 100.00		CAP2_HUMAN (1-473): 0: 647: 63.05
+	Hs
		768474 Q1KLZ0_HUMAN (1-375): 0: 603: 100.00		CAP2_HUMAN (1-473): 0: 647: 63.05
+	Hs
		768466 ACTG_HUMAN (1-375): 0: 601: 98.93		CAP2_HUMAN (1-473): 0: 647: 63.05
+	Hs
		768467 ACTC_HUMAN (2-375): 0: 592: 94.12		CAP2_HUMAN (1-473): 0: 647: 63.05
+	Hs
		768468 ACTS_HUMAN (2-375): 0: 592: 93.58		CAP2_HUMAN (1-473): 0: 647: 63.05
+	Dm
		501500 ACT1_DROME (2-375): 0: 598: 98.13		Q7KN55_DROME (4-475): 0: 552: 42.89
+	Dm
		501544 ACT1_DROME (2-375): 0: 598: 98.13		Q9VPX7_DROME (43-475): 0: 552: 46.79
+	Dm
		361155 ACT2_DROME (2-375): 0: 596: 97.59		Q9VPX7_DROME (43-475): 0: 552: 46.79
+	Dm
		501543 ACT1_DROME (2-375): 0: 598: 98.13		Q9VPX6_DROME (4-475): 0: 530: 42.89
+	Dm
		361154 ACT2_DROME (2-375): 0: 596: 97.59		Q9VPX6_DROME (4-475): 0: 530: 42.89
+	Dm
		501456 ACT5_DROME (2-375): 0: 596: 95.99		Q9VPX6_DROME (4-475): 0: 530: 42.89
+	Dm
		862578 ACT3_DROME (2-375): 0: 594: 95.46		Q9VPX6_DROME (4-475): 0: 530: 42.89
+	Dm
		950127 ACT6_DROME (2-375): 0: 594: 95.99		Q9VPX6_DROME (4-475): 0: 530: 42.89
+	Sp
		501577 ACT_SCHPO (1-375): 0: 592: 90.40		CAP_SCHPO (14-473): 8.25e-175: 503: 32.92