HitPredict

Interactor 1: ACTB (P60709)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Interactor 2: CALD1 (Q05682)
Caldesmon (CDM)
Gene: CALD1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	34079125, 37071682
Identification Methods	proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0005886 - plasma membrane GO:0015629 - actin cytoskeleton
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 375 Hs			1 793
+	Hs
		984609 POTEE_HUMAN (1-375): 0: 736: 92.00		CALD1_HUMAN (1-793): 4.35e-43: 169: 100.00
+	Hs
		984599 ACTBL_HUMAN (2-375): 0: 735: 91.71		CALD1_HUMAN (1-793): 4.35e-43: 169: 100.00
+	Hs
		724859 ACTBL_HUMAN (2-375): 0: 735: 91.71		MYH9_HUMAN (2-631): 8.69e-22: 103: 10.87
+	Hs
		929831 ACTG_HUMAN (1-375): 0: 601: 98.93		CALD1_HUMAN (1-793): 4.35e-43: 169: 100.00
+	Hs
		891935 ACTB_HUMAN (1-375): 0: 603: 100.00		MY18A_HUMAN (9-628): 1.86e-28: 125: 15.98
+	Hs
		929952 ACTG_HUMAN (1-375): 0: 601: 98.93		MY18A_HUMAN (9-628): 1.86e-28: 125: 15.98
+	Rn
		892236 ACTB_RAT (1-375): 0: 603: 100.00		MYH10_RAT (55-785): 3.7e-26: 117: 10.67
+	Hs
		933030 ACTS_HUMAN (2-375): 0: 592: 93.58		MY18A_HUMAN (9-628): 1.86e-28: 125: 15.98
+	Mm
		892205 ACTB_MOUSE (1-375): 0: 603: 100.00		MYH9_MOUSE (2-638): 2.4e-23: 108: 10.87
+	Hs
		724738 ACTB_HUMAN (1-375): 0: 603: 100.00		MYH9_HUMAN (2-631): 8.69e-22: 103: 10.87
+	Rn
		892228 ACTB_RAT (1-375): 0: 603: 100.00		MYH9_RAT (2-603): 1.07e-21: 103: 10.66
+	Hs
		724762 ACTG_HUMAN (1-375): 0: 601: 98.93		MYH9_HUMAN (2-631): 8.69e-22: 103: 10.87
+	Hs
		724767 ACTS_HUMAN (2-375): 0: 592: 93.58		MYH9_HUMAN (2-631): 8.69e-22: 103: 10.87
+	Hs
		929869 ACTG_HUMAN (1-375): 0: 601: 98.93		PLEC_HUMAN (5-781): 2.36e-17: 89.5: 9.94
+	Rn
		92841 ACTB_RAT (1-375): 0: 603: 100.00		CTRO_RAT (81-718): 1.96e-16: 86.4: 9.75
+	Hs
		891686 ACTB_HUMAN (1-375): 0: 603: 100.00		MAP1A_HUMAN (212-642): 6.08e-13: 75: 18.04
+	Dm
		116373 ACT1_DROME (2-375): 0: 598: 98.13		M9PI41_DROME (26-625): 3.38e-10: 65.9: 12.21
+	Hs
		930015 ACTG_HUMAN (1-375): 0: 601: 98.93		MYO5C_HUMAN (13-485): 5.4e-09: 62.2: 14.38
+	Dm
		116372 ACT2_DROME (2-375): 0: 596: 97.59		M9PI41_DROME (26-625): 3.38e-10: 65.9: 12.21
+	Dm
		54871 ACT6_DROME (2-375): 0: 594: 95.99		A1ZA72_DROME (138-632): 5.06e-09: 62.2: 17.72