HitPredict

Interactor 1: ACTB (P60709)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Interactor 2: PKHG6 (Q3KR16)
Pleckstrin homology domain-containing family G member 6 (PH domain-containing family G member 6) (Myosin-interacting guanine nucleotide exchange factor) (MyoGEF)
Gene: PLEKHG6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 375 Hs			1 790
+	Hs
		915396 ACTA_HUMAN (2-375): 0: 591: 94.12		PKHG6_HUMAN (1-790): 4.02e-174: 522: 100.00
+	Hs
		1164361 POTEE_HUMAN (1-375): 0: 736: 92.00		FGD4_HUMAN (59-692): 2.85e-89: 299: 14.62
+	Hs
		1164359 POTEE_HUMAN (1-375): 0: 736: 92.00		Q96D37_HUMAN (99-662): 2.52e-88: 297: 14.98
+	Hs
		1164390 POTEE_HUMAN (1-375): 0: 736: 92.00		PKHG1_HUMAN (109-746): 6.19e-85: 297: 16.98
+	Hs
		548727 POTEE_HUMAN (1-375): 0: 736: 92.00		VAV_HUMAN (99-662): 1.12e-87: 297: 14.98
+	Hs
		548718 ACTBL_HUMAN (2-375): 0: 735: 91.71		VAV_HUMAN (99-662): 1.12e-87: 297: 14.98
+	Hs
		167091 POTEE_HUMAN (1-375): 0: 736: 92.00		ARHGB_HUMAN (22-750): 2.8e-83: 292: 17.48
+	Hs
		1164373 POTEE_HUMAN (1-375): 0: 736: 92.00		ECT2_HUMAN (77-645): 3.51e-80: 277: 19.26
+	Mm
		929793 ACTG_MOUSE (1-375): 0: 601: 98.93		PKHG5_MOUSE (2-774): 1.42e-109: 361: 32.93
+	Hs
		891981 ACTB_HUMAN (1-375): 0: 603: 100.00		FGD4_HUMAN (59-692): 2.85e-89: 299: 14.62
+	Hs
		548675 ACTA_HUMAN (2-375): 0: 591: 94.12		VAV_HUMAN (99-662): 1.12e-87: 297: 14.98
+	Hs
		932384 ACTC_HUMAN (2-375): 0: 592: 94.12		ECT2_HUMAN (77-645): 3.51e-80: 277: 19.26