HitPredict

Interactor 1: ACTB (P60709)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Interactor 2: RUVB1 (Q9Y265)
RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha)
Gene: RUVBL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

The method score is based on:

Property	Details
Experiments	17643375, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	Actin~TIP49
Common GO terms	GO:0000786 - nucleosome GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol and 13 others more... GO:0006338 - chromatin remodeling GO:0006357 - regulation of transcription by RNA polymerase II GO:0016020 - membrane GO:0016363 - nuclear matrix GO:0016887 - ATP hydrolysis activity GO:0035267 - NuA4 histone acetyltransferase complex GO:0042981 - regulation of apoptotic process GO:0045893 - positive regulation of DNA-templated transcription GO:0051726 - regulation of cell cycle GO:0070062 - extracellular exosome GO:1905168 - positive regulation of double-strand break repair via homologous recombination GO:1990904 - ribonucleoprotein complex GO:2000779 - regulation of double-strand break repair
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1	375
Hs

1	456

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024