Protein: TRI68
E3 ubiquitin-protein ligase TRIM68 (EC 2.3.2.27) (RING finger protein 137) (RING-type E3 ubiquitin transferase TRIM68) (SSA protein SS-56) (SS-56) (Tripartite motif-containing protein 68)

Gene: TRI68, TRIM68
Organism: Homo sapiens
Interactions: 117
UniProt ID: Q6AZZ1

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1231166

TRI68
E3 ubiquitin-protein ligase TRIM68

2

16

High-throughput

0.783

High

1231175

LNX1
E3 ubiquitin-protein ligase LNX

2

8

High-throughput

0.783

High

137385

BT3A3
Butyrophilin subfamily 3 member A3

1

17

High-throughput

0.691

High

292841

GRAP2
GRB2-related adapter protein 2

3

16

High-throughput

0.667

High

303064

CCN5
CCN family member 5

3

1

High-throughput

0.667

High

1231181

LENG1
Leukocyte receptor cluster member 1

3

1

High-throughput

0.667

High

561126

GILT
Gamma-interferon-inducible lysosomal thiol reductase

3

0

High-throughput

0.638

High

1098563

GPS2
G protein pathway suppressor 2

3

0

High-throughput

0.638

High

1231195

MMP28
Matrix metalloproteinase-28

3

0

High-throughput

0.634

High

908633

PRELP
Prolargin

4

3

High-throughput

0.630

High

326219

AGFG2
Arf-GAP domain and FG repeat-containing protein 2

2

1

High-throughput

0.628

High

709297

CCN2
CCN family member 2

2

1

High-throughput

0.628

High

137505

BT3A1
Butyrophilin subfamily 3 member A1

1

17

High-throughput

0.618

High

1231191

COL11
Collectin-11

3

2

High-throughput

0.609

High

74348

ZBT42
Zinc finger and BTB domain-containing protein 42

2

20

High-throughput

0.606

High

587107

ITF2
Transcription factor 4

2

2

High-throughput

0.606

High

1048883

REL
Proto-oncogene c-Rel

2

5

High-throughput

0.606

High

1081390

INCA1
Protein INCA1

2

1

High-throughput

0.606

High

1187719

KR133
Keratin-associated protein 13-3

2

1

High-throughput

0.606

High

1198017

KR132
Keratin-associated protein 13-2

2

1

High-throughput

0.606

High

1231186

AP4AT
AP-4 complex accessory subunit Tepsin

2

2

High-throughput

0.606

High

1231190

TIRR
Tudor-interacting repair regulator protein

2

1

High-throughput

0.606

High

1231199

DISC1
Disrupted in schizophrenia 1 protein

2

1

High-throughput

0.606

High

1231169

PRS48
Serine protease 48

3

1

High-throughput

0.604

High

376958

GON1
Progonadoliberin-1

2

0

High-throughput

0.602

High

1216467

AHDC1
Transcription factor Gibbin

2

0

High-throughput

0.602

High

1231203

PILRA
Paired immunoglobulin-like type 2 receptor alpha

3

1

High-throughput

0.599

High

1231197

AUNIP
Aurora kinase A- and ninein-interacting protein

2

0

High-throughput

0.595

High

976100

RPB7
DNA-directed RNA polymerase II subunit RPB7

2

0

High-throughput

0.580

High

1231198

LZTL1
Leucine zipper transcription factor-like protein 1

2

0

High-throughput

0.580

High

85997

IGLL5
Immunoglobulin lambda-like polypeptide 5

1

0

High-throughput

0.578

High

1231179

RN166
E3 ubiquitin-protein ligase RNF166

1

18

High-throughput

0.575

High

1231180

MOAP1
Modulator of apoptosis 1

1

3

Small-scale

0.561

High

1104293

BT1A1
Butyrophilin subfamily 1 member A1

1

16

Small-scale

0.553

High

1231201

FBLN5
Fibulin-5

2

2

High-throughput

0.549

High

943585

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

3

High-throughput

0.541

High

326344

SCAF4
SR-related and CTD-associated factor 4

1

2

High-throughput

0.536

High

610714

TCPA
T-complex protein 1 subunit alpha

1

4

High-throughput

0.536

High

655234

SFPQ
Splicing factor, proline- and glutamine-rich

1

7

High-throughput

0.536

High

718410

CD6
T-cell differentiation antigen CD6

1

1

High-throughput

0.536

High

724999

HXA9
Homeobox protein Hox-A9

1

6

High-throughput

0.536

High

821408

TCPZ
T-complex protein 1 subunit zeta

1

5

High-throughput

0.536

High

876016

TCPE
T-complex protein 1 subunit epsilon

1

7

High-throughput

0.536

High

881977

TCPG
T-complex protein 1 subunit gamma

1

7

High-throughput

0.536

High

899087

TCPQ
T-complex protein 1 subunit theta

1

8

High-throughput

0.536

High

899435

TCPD
T-complex protein 1 subunit delta

1

6

High-throughput

0.536

High

1007077

TCPB
T-complex protein 1 subunit beta

1

7

High-throughput

0.536

High

1048266

HGFA
Hepatocyte growth factor activator serine protease

1

1

High-throughput

0.536

High

1058861

ZO1
Tight junction protein 1

1

4

High-throughput

0.536

High

1059874

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

2

High-throughput

0.536

High

1181380

P3H1
Prolyl 3-hydroxylase 1

1

1

High-throughput

0.536

High

1229239

RHG17
Rho GTPase-activating protein 17

1

4

High-throughput

0.536

High

1231170

RAI1
Retinoic acid-induced protein 1

1

3

High-throughput

0.536

High

1231174

CPXM2
Inactive carboxypeptidase-like protein X2

1

2

High-throughput

0.536

High

1231176

TCPW
T-complex protein 1 subunit zeta-2

1

6

High-throughput

0.536

High

1231188

TCPH
T-complex protein 1 subunit eta

1

7

High-throughput

0.536

High

1231194

RBM38
RNA-binding protein 38

1

7

High-throughput

0.536

High

1231204

CHIP
E3 ubiquitin-protein ligase CHIP

1

2

High-throughput

0.536

High

1231206

DMRT1
Doublesex- and mab-3-related transcription factor 1

1

2

High-throughput

0.536

High

1231167

TECT3
Tectonic-3

1

0

High-throughput

0.513

High

1231185

PGRP3
Peptidoglycan recognition protein 3

1

0

High-throughput

0.513

High

957102

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

20

Small-scale

0.501

High

1218718

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

20

High-throughput

0.494

High

191480

CCL16
C-C motif chemokine 16

1

1

High-throughput

0.489

High

270458

FZD7
Frizzled-7

1

1

High-throughput

0.489

High

772317

FBN2
Fibrillin-2 [Cleaved into: Placensin]

1

2

High-throughput

0.489

High

906290

GPC3
Glypican-3

1

1

High-throughput

0.489

High

1132096

LTBP2
Latent-transforming growth factor beta-binding protein 2

1

1

High-throughput

0.489

High

1231168

THSD4
Thrombospondin type-1 domain-containing protein 4

1

2

High-throughput

0.489

High

1231184

CREL1
Protein disulfide isomerase CRELD1

1

3

High-throughput

0.489

High

1231192

C1QT7
Complement C1q tumor necrosis factor-related protein 7

1

3

High-throughput

0.489

High

1231207

CXA3
Gap junction alpha-3 protein

1

3

High-throughput

0.489

High

474747

VIME
Vimentin

1

9

Small-scale

0.479

High

520128

ANDR
Androgen receptor

1

6

Small-scale

0.479

High

573523

ENPL
Endoplasmin

1

14

Small-scale

0.479

High

576434

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

7

Small-scale

0.479

High

730670

1433S
14-3-3 protein sigma

1

11

High-throughput

0.479

High

971641

1433E
14-3-3 protein epsilon

1

2

High-throughput

0.479

High

1113383

CUL3
Cullin-3

1

12

High-throughput

0.479

High

1140416

KIF14
Kinesin-like protein KIF14

1

16

High-throughput

0.479

High

1231177

TFG
Protein TFG

1

3

Small-scale

0.479

High

1231178

KAT5
Histone acetyltransferase KAT5

1

1

Small-scale

0.479

High

1231193

NLRP1
NACHT, LRR and PYD domains-containing protein 1

1

15

Small-scale

0.479

High

1231172

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.458

High

69791

ZN785
Zinc finger protein 785

1

20

High-throughput

0.445

High

273882

CNOT3
CCR4-NOT transcription complex subunit 3

1

4

High-throughput

0.445

High

787558

TNR3
Tumor necrosis factor receptor superfamily member 3

1

3

High-throughput

0.445

High

1144373

NONO
Non-POU domain-containing octamer-binding protein

1

8

High-throughput

0.445

High

1231187

NUDC1
NudC domain-containing protein 1

1

1

High-throughput

0.445

High

1231200

CAH10
Carbonic anhydrase-related protein 10

1

1

High-throughput

0.445

High

91710

C9JJ79
Paired immunoglobin like type 2 receptor alpha

1

1

High-throughput

0.407

High

889927

VEGFB
Vascular endothelial growth factor B

4

0

High-throughput

0.360

High

1231171

TM139
Transmembrane protein 139

3

0

High-throughput

0.347

High

1231173

GNT2A
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase

3

0

High-throughput

0.347

High

757425

NTF4
Neurotrophin-4

3

0

High-throughput

0.345

High

1231205

COLQ
Acetylcholinesterase collagenic tail peptide

3

0

High-throughput

0.345

High

1231189

SMR3A
Submaxillary gland androgen-regulated protein 3A

2

0

High-throughput

0.328

High

339197

CA105
Uncharacterized protein C1orf105

2

0

High-throughput

0.324

High

154531

PLPP1
Phospholipid phosphatase 1

2

0

High-throughput

0.319

High

1231182

MMAB
Corrinoid adenosyltransferase MMAB

2

0

High-throughput

0.313

High

249049

NRP2
Neuropilin-2

1

0

High-throughput

0.279

Low

834929

FOLR3
Folate receptor gamma

1

0

High-throughput

0.279

Low

933976

APOC4
Apolipoprotein C-IV

1

0

High-throughput

0.279

Low

937403

LAMB2
Laminin subunit beta-2

1

0

High-throughput

0.279

Low

1063917

LOXL1
Lysyl oxidase homolog 1

1

0

High-throughput

0.279

Low

1159383

ECM1
Extracellular matrix protein 1

1

0

High-throughput

0.279

Low

1211480

FREM2
FRAS1-related extracellular matrix protein 2

1

0

High-throughput

0.279

Low

1231183

F163A
Protein FAM163A

1

0

High-throughput

0.279

Low

1231196

CA021
Uncharacterized protein C1orf21

1

0

High-throughput

0.279

Low

441543

CCKN
Cholecystokinin

1

0

High-throughput

0.269

Low

686676

ASPX
Acrosomal protein SP-10

1

0

High-throughput

0.269

Low

49524

SHSA3
Protein shisa-3 homolog

1

0

High-throughput

0.232

Low

230972

TYOBP
TYRO protein tyrosine kinase-binding protein

1

0

High-throughput

0.232

Low

430709

REG1A
Lithostathine-1-alpha

1

0

High-throughput

0.232

Low

1108882

PNOC
Prepronociceptin [Cleaved into: Nocistatin; Nociceptin

1

0

High-throughput

0.232

Low

1231202

EGFL7
Epidermal growth factor-like protein 7

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025