HitPredict

Interactor 1: ACTB (P60709)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Interactor 2: SCIN (Q9Y6U3)
Scinderin (Adseverin)
Gene: SCIN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	34079125, 33961781, 35271311
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~Gelsolin
Common GO terms	GO:0005737 - cytoplasm GO:0005903 - brush border GO:0015629 - actin cytoskeleton GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 375 Hs			1 715
+	Hs
		1122544 ACTBL_HUMAN (2-375): 0: 735: 91.71		SCIN_HUMAN (1-715): 0: 1071: 100.00
+	Hs
		474864 POTEI_HUMAN (1-375): 0: 731: 91.20		SCIN_HUMAN (1-715): 0: 1071: 100.00
+	Hs
		413941 ACTBL_HUMAN (2-375): 0: 735: 91.71		GELS_HUMAN (2-715): 0: 1033: 59.86
+	Hs
		413807 POTEI_HUMAN (1-375): 0: 731: 91.20		GELS_HUMAN (2-715): 0: 1033: 59.86
+	Hs
		930076 ACTG_HUMAN (1-375): 0: 601: 98.93		SCIN_HUMAN (1-715): 0: 1071: 100.00
+	Hs
		932481 ACTC_HUMAN (2-375): 0: 592: 94.12		SCIN_HUMAN (1-715): 0: 1071: 100.00
+	Hs
		933081 ACTS_HUMAN (2-375): 0: 592: 93.58		SCIN_HUMAN (1-715): 0: 1071: 100.00
+	Hs
		413874 ACTB_HUMAN (1-375): 0: 603: 100.00		GELS_HUMAN (2-715): 0: 1033: 59.86
+	Hs
		413884 ACTG_HUMAN (1-375): 0: 601: 98.93		GELS_HUMAN (2-715): 0: 1033: 59.86
+	Oc
		101997 ACTB_RABIT (1-375): 0: 601: 99.73		G1U9R8_RABIT (2-715): 0: 1029: 59.86
+	Hs
		413885 ACTC_HUMAN (2-375): 0: 592: 94.12		GELS_HUMAN (2-715): 0: 1033: 59.86
+	Hs
		413886 ACTS_HUMAN (2-375): 0: 592: 93.58		GELS_HUMAN (2-715): 0: 1033: 59.86
+	Hs
		413881 ACTA_HUMAN (2-375): 0: 591: 94.12		GELS_HUMAN (2-715): 0: 1033: 59.86
+	Hs
		891735 ACTB_HUMAN (1-375): 0: 603: 100.00		FLII_HUMAN (6-713): 0: 741: 27.38
+	Hs
		929839 ACTG_HUMAN (1-375): 0: 601: 98.93		FLII_HUMAN (6-713): 0: 741: 27.38
+	Hs
		932132 ACTC_HUMAN (2-375): 0: 592: 94.12		FLII_HUMAN (6-713): 0: 741: 27.38
+	Dm
		950116 ACT6_DROME (2-375): 0: 594: 95.99		FLII_DROME (6-714): 0: 716: 27.89
+	Dm
		501491 ACT1_DROME (2-375): 0: 598: 98.13		QUAI_DROME (7-714): 0: 624: 23.26
+	Bt
		221227 ACTB_BOVIN (1-375): 0: 603: 100.00		SVIL_BOVIN (21-347): 2.8e-32: 137: 21.47
+	Hs
		313786 ACTB_HUMAN (1-375): 0: 603: 100.00		SVIL_HUMAN (21-347): 1.62e-31: 134: 21.73