HitPredict

Interactor 1: RAC3 (P60763)
Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3)
Gene: RAC3

Interactor 2: GRDN (Q3V6T2)
Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1)
Gene: CCDC88A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030027 - lamellipodium GO:0031410 - cytoplasmic vesicle GO:0032956 - regulation of actin cytoskeleton organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 1871
+	Hs
		925322 RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71		GRDN_HUMAN (1-1871): 2.19e-149: 509: 100.00
+	Hs
		545414 RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54		GRDN_HUMAN (1-1871): 2.19e-149: 509: 100.00
+	Hs
		1113848 RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32		GRDN_HUMAN (1-1871): 2.19e-149: 509: 100.00
+	Hs
		951040 RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79		GRDN_HUMAN (1-1871): 2.19e-149: 509: 100.00
+	Hs
		724757 RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71		MYH9_HUMAN (1-809): 2.13e-29: 130: 10.02
+	Hs
		724776 RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79		MYH9_HUMAN (1-809): 2.13e-29: 130: 10.02
+	Hs
		148653 RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71		CTRO_HUMAN (144-645): 2.42e-16: 88.1: 16.63
+	Hs
		725138 RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79		MYH10_HUMAN (43-620): 1.66e-20: 101: 9.86
+	Hs
		925488 RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71		MY18A_HUMAN (599-1309): 1.19e-12: 75.9: 20.46
+	Mm
		823530 RAC1_MOUSE (1-192): 1.92e-84: 249: 92.71		CTRO_MOUSE (468-1226): 3.12e-11: 71.2: 20.41
+	Hs
		545357 RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54		GOGA4_HUMAN (1253-1786): 2.42e-13: 78.1: 7.84
+	Hs
		545537 RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54		MY18A_HUMAN (599-1309): 1.19e-12: 75.9: 20.46
+	Hs
		254468 RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71		ROCK2_HUMAN (244-1010): 3.06e-09: 64.3: 20.76
+	Hs
		892351 RAC3_HUMAN (1-192): 5.54e-79: 235: 100.00		GOGA4_HUMAN (1253-1786): 2.42e-13: 78.1: 7.84
+	Hs
		950972 RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79		GOGA4_HUMAN (1253-1786): 2.42e-13: 78.1: 7.84
+	Hs
		892521 RAC3_HUMAN (1-192): 5.54e-79: 235: 100.00		MY18A_HUMAN (599-1309): 1.19e-12: 75.9: 20.46
+	Hs
		254512 RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32		ROCK2_HUMAN (244-1010): 3.06e-09: 64.3: 20.76
+	Mm
		823529 CDC42_MOUSE (1-192): 3.66e-77: 230: 68.75		CTRO_MOUSE (468-1226): 3.12e-11: 71.2: 20.41
+	Hs
		254462 RAC3_HUMAN (1-192): 5.54e-79: 235: 100.00		ROCK2_HUMAN (244-1010): 3.06e-09: 64.3: 20.76
+	Hs
		254472 RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79		ROCK2_HUMAN (244-1010): 3.06e-09: 64.3: 20.76