HitPredict

Interactor 1: RAC3 (P60763)
Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3)
Gene: RAC3

Interactor 2: MICA3 (Q7RTP6)
[F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3)
Gene: MICAL3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~bMERB_dom
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 2002
+	Hs
		925387 RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71		MICA3_HUMAN (1-2002): 0: 1314: 100.00
+	Hs
		1186089 RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32		MICA3_HUMAN (1-2002): 0: 1314: 100.00
+	Hs
		925201 RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71		SPTB2_HUMAN (433-1059): 2.31e-85: 314: 16.56
+	Hs
		545327 RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54		SPTB2_HUMAN (433-1059): 2.31e-85: 314: 16.56
+	Hs
		963416 RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32		SPTB2_HUMAN (433-1059): 2.31e-85: 314: 16.56
+	Hs
		892322 RAC3_HUMAN (1-192): 5.54e-79: 235: 100.00		SPTB2_HUMAN (433-1059): 2.31e-85: 314: 16.56
+	Hs
		950929 RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79		SPTB2_HUMAN (433-1059): 2.31e-85: 314: 16.56
+	Hs
		164599 RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71		SPTN2_HUMAN (433-1216): 1.38e-79: 295: 14.86
+	Hs
		164665 RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32		SPTN2_HUMAN (433-1216): 1.38e-79: 295: 14.86
+	Hs
		164589 RAC3_HUMAN (1-192): 5.54e-79: 235: 100.00		SPTN2_HUMAN (433-1216): 1.38e-79: 295: 14.86
+	Hs
		164602 RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79		SPTN2_HUMAN (433-1216): 1.38e-79: 295: 14.86
+	Dd
		710112 RAC1A_DICDI (1-192): 1.39e-80: 239: 78.35		CTXA_DICDI (506-781): 1.29e-54: 200: 21.75
+	Hs
		925443 RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71		EHBP1_HUMAN (520-762): 2.11e-37: 156: 22.53
+	Hs
		545503 RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54		EHBP1_HUMAN (520-762): 2.11e-37: 156: 22.53
+	Hs
		1242508 RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32		EHBP1_HUMAN (520-762): 2.11e-37: 156: 22.53
+	Hs
		892491 RAC3_HUMAN (1-192): 5.54e-79: 235: 100.00		EHBP1_HUMAN (520-762): 2.11e-37: 156: 22.53
+	Ce
		136793 RAC1_CAEEL (1-192): 1.53e-82: 244: 81.25		UNC89_CAEEL (1306-1897): 2.14e-29: 131: 11.73
+	Hs
		925433 RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71		MILK1_HUMAN (715-885): 2.96e-16: 87.2: 21.14
+	Hs
		1232332 RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32		MILK1_HUMAN (715-885): 2.96e-16: 87.2: 21.14
+	Hs
		892482 RAC3_HUMAN (1-192): 5.54e-79: 235: 100.00		MILK1_HUMAN (715-885): 2.96e-16: 87.2: 21.14