HitPredict

Interactor 1: RAC3 (P60763)
Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3)
Gene: RAC3

Interactor 2: IQGA3 (Q86VI3)
Ras GTPase-activating-like protein IQGAP3
Gene: IQGAP3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	33961781, 31871319
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ras~RasGAP
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 1631
+	Hs
		925404 RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71		IQGA3_HUMAN (1-1631): 0: 1709: 100.00
+	Hs
		809255 RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71		IQGA1_HUMAN (6-1631): 0: 1574: 58.99
+	Hs
		545255 RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54		IQGA1_HUMAN (6-1631): 0: 1574: 58.99
+	Hs
		809436 RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32		IQGA1_HUMAN (6-1631): 0: 1574: 58.99
+	Mm
		925821 RAC1_MOUSE (1-192): 1.92e-84: 249: 92.71		IQGA1_MOUSE (7-1631): 0: 1543: 58.85
+	Hs
		925259 RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71		IQGA2_HUMAN (86-1631): 0: 1356: 42.50
+	Hs
		1040058 RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32		IQGA2_HUMAN (86-1631): 0: 1356: 42.50
+	Dd
		710113 RAC1A_DICDI (1-192): 1.39e-80: 239: 78.35		RGAA_DICDI (824-1629): 1.32e-149: 481: 27.49
+	Dd
		136239 RAC1A_DICDI (1-192): 1.39e-80: 239: 78.35		GAPA_DICDI (828-1630): 3.05e-136: 445: 25.98
+	Hs
		925282 RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71		RASA3_HUMAN (841-1504): 2.12e-105: 359: 13.68
+	Hs
		545380 RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54		RASA3_HUMAN (841-1504): 2.12e-105: 359: 13.68
+	Hs
		925728 RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71		MYO5B_HUMAN (696-1522): 2.83e-96: 346: 14.42
+	Hs
		925715 RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71		NGAP_HUMAN (1000-1453): 5.22e-81: 294: 17.18
+	Hs
		545691 RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54		NGAP_HUMAN (1000-1453): 5.22e-81: 294: 17.18
+	Gg
		1141019 Q6LC82_CHICK (1-192): 1.92e-84: 249: 92.71		ARHG6_CHICK (37-448): 7.38e-77: 274: 11.83
+	Hs
		925347 RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71		DAB2P_HUMAN (1000-1424): 2.56e-68: 255: 15.03
+	Hs
		925530 RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71		SYGP1_HUMAN (1000-1345): 1.08e-65: 247: 16.44
+	Hs
		545434 RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54		DAB2P_HUMAN (1000-1424): 2.56e-68: 255: 15.03
+	Hs
		598457 RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71		NF1_HUMAN (967-1301): 9.74e-45: 181: 21.57
+	Hs
		598525 RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32		NF1_HUMAN (967-1301): 9.74e-45: 181: 21.57