HitPredict

Interactor 1: IF4A1 (P60842)
Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1)
Gene: EIF4A1

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35563538, 21145461
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 406 Hs			1 768
+	Hs
		1042199 DDX17_HUMAN (2-406): 1.31e-136: 409: 29.33		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		571443 DDX5_HUMAN (10-406): 3.38e-138: 409: 29.88		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Mm
		1207268 Q8BTS0_MOUSE (10-406): 4.82e-138: 409: 29.88		CUL3_MOUSE (1-768): 0: 949: 99.48
+	Hs
		757603 IF4A3_HUMAN (1-406): 1.93e-134: 393: 66.75		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		640470 DDX6_HUMAN (32-402): 1.66e-88: 278: 38.71		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		571444 DDX5_HUMAN (10-406): 3.38e-138: 409: 29.88		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		1043492 DDX17_HUMAN (2-406): 1.31e-136: 409: 29.33		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		571445 DDX5_HUMAN (10-406): 3.38e-138: 409: 29.88		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		1041127 DDX17_HUMAN (2-406): 1.31e-136: 409: 29.33		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		571441 DDX5_HUMAN (10-406): 3.38e-138: 409: 29.88		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		757602 IF4A3_HUMAN (1-406): 1.93e-134: 393: 66.75		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		892797 IF4A1_HUMAN (1-406): 1.84e-132: 387: 100.00		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		1041422 DDX17_HUMAN (2-406): 1.31e-136: 409: 29.33		CUL2_HUMAN (30-768): 0: 672: 26.17
+	Hs
		571442 DDX5_HUMAN (10-406): 3.38e-138: 409: 29.88		CUL2_HUMAN (30-768): 0: 672: 26.17
+	Sc
		485855 IF4A_YEAST (20-406): 8.01e-168: 477: 66.41		CDC53_YEAST (30-768): 0: 573: 22.08
+	Hs
		571542 DDX5_HUMAN (10-406): 3.38e-138: 409: 29.88		CUL5_HUMAN (25-768): 0: 597: 23.77