Protein: 2AAA
Protein phosphatase PP2A regulatory subunit A (PR65)

Gene: 2AAA, TPD3
Organism: Saccharomyces cerevisiae S288C
Interactions: 87
UniProt ID: P31383

Gene Ontology (top 5):
GO:0000159 - protein phosphatase type 2A complex
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005816 - spindle pole body
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

660776

PP2A1
Serine/threonine-protein phosphatase PP2A-1 catalytic subunit

10

20

Small-scale

0.977

High

660839

PP2A2
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

8

20

Small-scale

0.969

High

726145

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

6

20

Small-scale

0.943

High

726134

PP2A4
Serine/threonine-protein phosphatase PP2A-like PPG1

5

20

Small-scale

0.915

High

726173

2ABA
Protein phosphatase PP2A regulatory subunit B

13

10

Small-scale

0.760

High

726171

ZDS2
Protein ZDS2

6

3

Small-scale

0.733

High

726165

ZDS1
Protein ZDS1

6

2

Small-scale

0.732

High

726192

PTPA2
Serine/threonine-protein phosphatase 2A activator 2

6

3

Small-scale

0.727

High

726144

KOG1
Target of rapamycin complex 1 subunit KOG1

1

9

High-throughput

0.713

High

726170

FAR11
Factor arrest protein 11

5

4

Small-scale

0.708

High

726168

RTS3
Protein phosphatase type 2A regulatory subunit RTS3

4

0

High-throughput

0.670

High

726148

SSB2
Ribosome-associated molecular chaperone SSB2

3

8

High-throughput

0.634

High

726143

KEL1
Kelch repeat-containing protein 1

2

5

High-throughput

0.621

High

460958

LTE1
Guanine nucleotide exchange factor LTE1

2

0

High-throughput

0.595

High

726155

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

2

High-throughput

0.584

High

726166

YOR1
Oligomycin resistance ATP-dependent permease YOR1

2

3

High-throughput

0.567

High

726184

SGO1
Shugoshin

2

0

Small-scale

0.559

High

523304

HSP71
Heat shock protein SSA1

2

7

High-throughput

0.552

High

726133

HSP7F
Heat shock protein homolog SSE1

2

12

High-throughput

0.552

High

726154

ARF3
ADP-ribosylation factor 3

1

3

High-throughput

0.541

High

726157

LSB3
LAS seventeen-binding protein 3

1

2

High-throughput

0.541

High

656386

KC11
Casein kinase I homolog 1

1

9

High-throughput

0.536

High

726141

KSP1
Serine/threonine-protein kinase KSP1

1

13

High-throughput

0.536

High

726176

CWC21
Pre-mRNA-splicing factor CWC21

1

1

High-throughput

0.536

High

726193

SKM1
Serine/threonine-protein kinase SKM1

1

14

High-throughput

0.536

High

726139

PGM2
Phosphoglucomutase 2

1

0

High-throughput

0.518

High

726140

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

1

High-throughput

0.515

High

383576

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.513

High

511752

RS24A
Small ribosomal subunit protein eS24A

1

0

High-throughput

0.513

High

655411

RS3A2
Small ribosomal subunit protein eS1B

1

0

High-throughput

0.513

High

726162

IKS1
Probable serine/threonine-protein kinase IKS1

1

6

High-throughput

0.501

High

726131

VATC
V-type proton ATPase subunit C

1

1

High-throughput

0.494

High

726163

BBC1
Myosin tail region-interacting protein MTI1

1

5

High-throughput

0.494

High

726188

YRR1
Zinc finger transcription factor YRR1

1

0

High-throughput

0.493

High

726153

ULP2
Ubiquitin-like-specific protease 2

1

1

High-throughput

0.481

High

726174

CDC14
Tyrosine-protein phosphatase CDC14

1

13

High-throughput

0.481

High

726175

ULP1
Ubiquitin-like-specific protease 1

1

1

High-throughput

0.481

High

726194

CMR1
DNA damage-binding protein CMR1

1

11

High-throughput

0.481

High

512314

RS6A
Small ribosomal subunit protein eS6A

1

2

High-throughput

0.479

High

579003

HSC82
ATP-dependent molecular chaperone HSC82

1

4

High-throughput

0.479

High

632410

CG12
G1/S-specific cyclin CLN2

1

1

Small-scale

0.479

High

679461

CDC48
Cell division control protein 48

1

5

High-throughput

0.479

High

706437

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.479

High

726132

HS104
Heat shock protein 104

1

2

High-throughput

0.479

High

726138

DEF1
RNA polymerase II degradation factor 1

1

1

High-throughput

0.479

High

726142

RPN1
26S proteasome regulatory subunit RPN1

1

2

High-throughput

0.479

High

726151

PTPA1
Serine/threonine-protein phosphatase 2A activator 1

1

3

Small-scale

0.479

High

726169

GIS2
Zinc finger protein GIS2

1

1

High-throughput

0.479

High

726177

VPS64
Vacuolar protein sorting-associated protein 64

1

6

High-throughput

0.479

High

726178

SCC2
Sister chromatid cohesion protein 2

1

2

High-throughput

0.479

High

726179

PDS5
Sister chromatid cohesion protein PDS5

1

2

High-throughput

0.479

High

726181

FAR8
Factor arrest protein 8

1

10

High-throughput

0.479

High

726182

FAR10
Factor arrest protein 10

1

6

High-throughput

0.479

High

726186

SCC1
Sister chromatid cohesion protein 1

1

1

High-throughput

0.479

High

726189

RIO1
Serine/threonine-protein kinase RIO1

1

3

High-throughput

0.479

High

726135

BCK2
Protein BCK2

1

0

Small-scale

0.460

High

726187

NBP2
NAP1-binding protein 2

1

0

High-throughput

0.460

High

726156

FAR7
Factor arrest protein 7

1

0

High-throughput

0.458

High

726167

PESC
Pescadillo homolog

1

0

High-throughput

0.458

High

726180

MYO5
Myosin-5

1

1

High-throughput

0.457

High

394329

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.445

High

427173

RLA0
Large ribosomal subunit protein uL10

1

1

High-throughput

0.445

High

434909

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.445

High

510279

HSP77
Import motor subunit, mitochondrial

1

6

High-throughput

0.445

High

526133

HSP72
Heat shock protein SSA2

1

7

High-throughput

0.445

High

531648

RL4A
Large ribosomal subunit protein uL4A

1

2

High-throughput

0.445

High

544102

SSB1
Ribosome-associated molecular chaperone SSB1

1

8

High-throughput

0.445

High

689319

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.445

High

712521

RL8B
Large ribosomal subunit protein eL8B

1

1

High-throughput

0.445

High

726136

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.445

High

726147

HSP7E
Heat shock protein SSC3, mitochondrial

1

6

High-throughput

0.445

High

726149

RL13B
Large ribosomal subunit protein eL13B

1

1

High-throughput

0.445

High

726160

PFD1
Prefoldin subunit 1

1

1

High-throughput

0.445

High

726164

RL4B
Large ribosomal subunit protein uL4B

1

2

High-throughput

0.445

High

726183

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

7

High-throughput

0.445

High

726190

RL7B
Large ribosomal subunit protein uL30B

1

1

High-throughput

0.445

High

726137

MPE1
Protein MPE1

1

0

High-throughput

0.438

High

726191

DBP10
ATP-dependent RNA helicase DBP10

1

6

High-throughput

0.437

High

670437

SIS1
Protein SIS1

1

0

High-throughput

0.426

High

726146

CAJ1
Protein CAJ1

1

0

High-throughput

0.426

High

726158

SA155
SIT4-associating protein SAP155

1

0

High-throughput

0.426

High

726161

RL17B
Large ribosomal subunit protein uL22B

1

0

High-throughput

0.426

High

726150

TCPE
T-complex protein 1 subunit epsilon

1

4

High-throughput

0.407

High

726172

PEX13
Peroxisomal membrane protein PEX13

1

0

High-throughput

0.282

High

726185

TGL5
Triacylglycerol lipase 5

1

0

High-throughput

0.282

High

726152

FIS1
Mitochondrial fission 1 protein

1

0

High-throughput

0.265

Low

726159

FAR3
Factor arrest protein 3

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025