HitPredict

Interactor 1: SEM1 (P60896)
26S proteasome complex subunit SEM1 (26S proteasome complex subunit DSS1) (Deleted in split hand/split foot protein 1) (Split hand/foot deleted protein 1) (Split hand/foot malformation type 1 protein)
Gene: SEM1

Interactor 2: PCID2 (Q5JVF3)
PCI domain-containing protein 2 (CSN12-like protein)
Gene: PCID2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.80	0.862

Property	Details
Experiments	32296183, 22343721, 16189514, 16239144, 24515614, unassigned1304, 35271311
Identification Methods	two hybrid, x-ray crystallography, affinity chromatography technology, molecular sieving, pull down, two hybrid array, two hybrid prey pooling approach, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, association, physical association

Property	Details
Interacting Pfam domains	DSS1_SEM1~PCI
Common GO terms	-
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 70 Hs			1 399
+	Hs
		198591 SEM1_HUMAN (1-70): 3.65e-23: 84.7: 100.00		PSMD3_HUMAN (4-389): 1.26e-89: 282: 16.71
+	Mm
		539501 SEM1_MOUSE (1-70): 3.65e-23: 84.7: 100.00		PSMD3_MOUSE (4-389): 7.47e-88: 277: 16.71
+	Dr
		1157473 Q7ZU84_DANRE (1-70): 5.47e-23: 84.3: 97.14		Q6NYV1_DANRE (4-389): 5.51e-79: 253: 16.71
+	Hs
		121718 SEM1_HUMAN (1-70): 3.65e-23: 84.7: 100.00		PSD11_HUMAN (111-395): 1.42e-29: 120: 14.09