Protein: GBG12
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

Gene: GBG12, GNG12
Organism: Homo sapiens
Interactions: 102
UniProt ID: Q9UBI6

Gene Ontology (top 5):
GO:0005834 - heterotrimeric G-protein complex
GO:0005886 - plasma membrane
GO:0007165 - signal transduction
GO:0007186 - G protein-coupled receptor signaling pathway
GO:0030165 - PDZ domain binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

983605

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

7

20

Small-scale

0.741

High

984316

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

4

20

Small-scale

0.676

High

1123159

FHL2
Four and a half LIM domains protein 2

5

1

High-throughput

0.655

High

597375

GBB3
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3

2

20

Small-scale

0.624

High

1453540

PD1L1
Programmed cell death 1 ligand 1

1

1

High-throughput

0.618

High

1125941

GNA13
Guanine nucleotide-binding protein subunit alpha-13

2

20

High-throughput

0.611

High

845840

MUC18
Cell surface glycoprotein MUC18

1

0

High-throughput

0.586

High

989887

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

2

20

High-throughput

0.584

High

476053

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

2

20

High-throughput

0.571

High

1095064

DUS4
Dual specificity protein phosphatase 4

2

1

High-throughput

0.571

High

1356776

HDAC7
Histone deacetylase 7

2

1

High-throughput

0.553

High

400034

CATA
Catalase

2

0

High-throughput

0.547

High

637772

FLNA
Filamin-A

1

2

High-throughput

0.536

High

891849

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.536

High

893537

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

1

20

High-throughput

0.536

High

902902

BLK
Tyrosine-protein kinase Blk

1

3

High-throughput

0.536

High

1103671

PHLP
Phosducin-like protein

1

11

High-throughput

0.536

High

1340253

MSPD2
Motile sperm domain-containing protein 2

1

3

High-throughput

0.536

High

773059

MYH9
Myosin-9

1

0

High-throughput

0.513

High

1368246

CDKL2
Cyclin-dependent kinase-like 2

1

0

High-throughput

0.513

High

1439394

KC1G1
Casein kinase I isoform gamma-1

1

0

High-throughput

0.513

High

1437752

GBB4
Guanine nucleotide-binding protein subunit beta-4

1

20

Small-scale

0.501

High

572962

INSRR
Insulin receptor-related protein

1

3

High-throughput

0.500

High

640316

EPHA1
Ephrin type-A receptor 1

1

3

High-throughput

0.500

High

710541

EPHA2
Ephrin type-A receptor 2

1

3

High-throughput

0.500

High

189021

TMPS2
Transmembrane protease serine 2

1

1

High-throughput

0.479

High

418759

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

20

High-throughput

0.479

High

458505

ADRB2
Beta-2 adrenergic receptor

1

2

High-throughput

0.479

High

482646

GNAO
Guanine nucleotide-binding protein G(o) subunit alpha

1

20

High-throughput

0.479

High

560545

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.479

High

1031578

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.479

High

1247026

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

1360955

CLC4D
C-type lectin domain family 4 member D

1

2

High-throughput

0.479

High

1367486

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1458432

CLC4E
C-type lectin domain family 4 member E

1

2

High-throughput

0.479

High

223396

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

538047

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

651449

CBL
E3 ubiquitin-protein ligase CBL

1

0

High-throughput

0.458

High

774682

BASI
Basigin

1

0

High-throughput

0.458

High

862513

YAP1
Transcriptional coactivator YAP1

1

0

High-throughput

0.458

High

930069

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

0

High-throughput

0.458

High

978374

RHOB
Rho-related GTP-binding protein RhoB

1

0

High-throughput

0.458

High

995866

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.458

High

1140981

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1433101

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

1458433

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

1

0

High-throughput

0.458

High

948955

CD81
CD81 antigen

1

4

High-throughput

0.445

High

248125

NUPR1
Nuclear protein 1

1

1

High-throughput

0.437

High

331386

KI20A
Kinesin-like protein KIF20A

1

2

High-throughput

0.437

High

373388

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.437

High

406756

MYCN
N-myc proto-oncogene protein

1

2

High-throughput

0.437

High

630073

BTF3
Transcription factor BTF3

1

1

High-throughput

0.437

High

1035966

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.437

High

1124315

IF4A2
Eukaryotic initiation factor 4A-II

1

1

High-throughput

0.437

High

1130030

KCTD2
BTB/POZ domain-containing protein KCTD2

1

12

Small-scale

0.437

High

1138132

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.437

High

1429969

RNF38
E3 ubiquitin-protein ligase RNF38

1

2

Small-scale

0.437

High

1436527

ECT2
Protein ECT2

1

1

High-throughput

0.437

High

1447385

ANLN
Anillin

1

1

High-throughput

0.437

High

1450908

RNF12
E3 ubiquitin-protein ligase RLIM

1

2

High-throughput

0.437

High

1452135

KCTD5
BTB/POZ domain-containing protein KCTD5

1

12

Small-scale

0.437

High

1458429

HDAC6
Protein deacetylase HDAC6

1

1

High-throughput

0.437

High

564493

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

1420748

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

1446222

SO1B3
Solute carrier organic anion transporter family member 1B3

1

0

High-throughput

0.426

High

337652

GNAS3
Neuroendocrine secretory protein 55

1

8

High-throughput

0.407

High

765963

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.407

High

166705

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

0

High-throughput

0.279

Low

808187

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.279

Low

1085934

TWF1
Twinfilin-1

1

0

High-throughput

0.279

Low

1164322

F264
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4

1

0

High-throughput

0.279

Low

1230735

Z518A
Zinc finger protein 518A

1

0

High-throughput

0.279

Low

1290230

PIM3
Serine/threonine-protein kinase pim-3

1

0

High-throughput

0.279

Low

1308328

LACC1
Purine nucleoside phosphorylase LACC1

1

0

High-throughput

0.279

Low

1310491

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

1332060

BANP
Protein BANP

1

0

High-throughput

0.279

Low

1353796

HASP
Serine/threonine-protein kinase haspin

1

0

High-throughput

0.279

Low

1436785

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.279

Low

1458431

MED23
Mediator of RNA polymerase II transcription subunit 23

1

0

High-throughput

0.279

Low

831578

CCNF
Cyclin-F

1

0

High-throughput

0.269

Low

1416935

KLF16
Krueppel-like factor 16

1

0

High-throughput

0.261

Low

129508

MEN1
Menin

1

0

High-throughput

0.249

Low

136147

PLK4
Serine/threonine-protein kinase PLK4

1

0

Small-scale

0.249

Low

158344

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.249

Low

294467

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

352579

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.249

Low

628854

TBP
TATA-box-binding protein

1

0

Small-scale

0.249

Low

1034702

MEF2A
Myocyte-specific enhancer factor 2A

1

0

Small-scale

0.249

Low

1086338

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.249

Low

1117318

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

High-throughput

0.249

Low

1118182

DX39B
Spliceosome RNA helicase DDX39B

1

0

High-throughput

0.249

Low

1197584

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

0

High-throughput

0.249

Low

1197736

MIDN
Midnolin

1

0

High-throughput

0.249

Low

1229735

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

1352807

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.249

Low

1383270

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.249

Low

1420374

TRI31
E3 ubiquitin-protein ligase TRIM31

1

0

High-throughput

0.249

Low

1420976

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.249

Low

1449238

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.249

Low

1458430

SEPT9
Septin-9

1

0

Small-scale

0.249

Low

653633

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low

1405533

ZBT18
Zinc finger and BTB domain-containing protein 18

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025