Protein: HAKAI
E3 ubiquitin-protein ligase Hakai (EC 2.3.2.27) (Casitas B-lineage lymphoma-transforming sequence-like protein 1) (c-Cbl-like protein 1) (RING finger protein 188) (RING-type E3 ubiquitin transferase Hakai)

Gene: HAKAI, CBLL1
Organism: Homo sapiens
Interactions: 69
UniProt ID: Q75N03

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

522023

CADH1
Cadherin-1

9

4

Small-scale

0.751

High

369883

ESR1
Estrogen receptor

3

20

Small-scale

0.658

High

523036

SRC
Proto-oncogene tyrosine-protein kinase Src

3

6

Small-scale

0.656

High

1148645

VIR
Protein virilizer homolog

2

3

High-throughput

0.611

High

958060

RBM10
RNA-binding protein 10

1

2

High-throughput

0.541

High

134096

DDX3X
ATP-dependent RNA helicase DDX3X

1

8

Small-scale

0.536

High

176808

EIF3D
Eukaryotic translation initiation factor 3 subunit D

1

1

Small-scale

0.536

High

213839

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

3

Small-scale

0.536

High

214969

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

1

Small-scale

0.536

High

571498

DDX5
Probable ATP-dependent RNA helicase DDX5

1

8

Small-scale

0.536

High

575767

VINC
Vinculin

1

2

Small-scale

0.536

High

642415

RL13
Large ribosomal subunit protein eL13

1

1

Small-scale

0.536

High

643885

SYVC
Valine--tRNA ligase

1

2

Small-scale

0.536

High

821282

TCPE
T-complex protein 1 subunit epsilon

1

1

Small-scale

0.536

High

825988

FAS
Fatty acid synthase

1

1

Small-scale

0.536

High

892835

IF4A1
Eukaryotic initiation factor 4A-I

1

9

Small-scale

0.536

High

973114

RL6
Large ribosomal subunit protein eL6

1

1

Small-scale

0.536

High

989831

RL18
Large ribosomal subunit protein eL18

1

1

Small-scale

0.536

High

991808

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

3

Small-scale

0.536

High

992825

SRSF1
Serine/arginine-rich splicing factor 1

1

1

Small-scale

0.536

High

1029559

TIF1B
Transcription intermediary factor 1-beta

1

10

Small-scale

0.536

High

1062754

FL2D
Pre-mRNA-splicing regulator WTAP

1

1

High-throughput

0.536

High

1084503

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

13

Small-scale

0.536

High

1101423

KI26B
Kinesin-like protein KIF26B

1

5

High-throughput

0.536

High

1175953

MTA70
N6-adenosine-methyltransferase catalytic subunit

1

1

High-throughput

0.536

High

1175958

DDX17
Probable ATP-dependent RNA helicase DDX17

1

8

Small-scale

0.536

High

1175964

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

1

High-throughput

0.536

High

862421

ACLY
ATP-citrate synthase

1

0

Small-scale

0.513

High

944300

PRKDC
DNA-dependent protein kinase catalytic subunit

1

0

Small-scale

0.513

High

1082844

CDC37
Hsp90 co-chaperone Cdc37

1

0

Small-scale

0.513

High

1085307

FSCN1
Fascin

1

0

Small-scale

0.513

High

1087858

PCKGM
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial

1

0

Small-scale

0.513

High

174990

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

6

High-throughput

0.501

High

647038

1433T
14-3-3 protein theta

1

19

High-throughput

0.501

High

894156

CDC42
Cell division control protein 42 homolog

1

9

Small-scale

0.501

High

949024

HTRA4
Serine protease HTRA4

1

1

High-throughput

0.489

High

1048700

DGCR6
Protein DGCR6

1

1

High-throughput

0.481

High

379537

MYCN
N-myc proto-oncogene protein

1

18

High-throughput

0.479

High

427598

ANXA2
Annexin A2

1

1

Small-scale

0.479

High

553021

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

613498

SFPQ
Splicing factor, proline- and glutamine-rich

1

3

Small-scale

0.479

High

651525

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

737888

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

8

High-throughput

0.479

High

917486

H4
Histone H4

1

4

High-throughput

0.479

High

927209

1433Z
14-3-3 protein zeta/delta

1

19

High-throughput

0.479

High

941085

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

980793

TLE3
Transducin-like enhancer protein 3

1

8

High-throughput

0.479

High

1014156

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

1

High-throughput

0.479

High

1019543

ILF2
Interleukin enhancer-binding factor 2

1

1

Small-scale

0.479

High

1041885

CUL3
Cullin-3

1

4

High-throughput

0.479

High

1052237

SRC8
Src substrate cortactin

1

16

Small-scale

0.479

High

1063461

SUZ12
Polycomb protein SUZ12

1

1

High-throughput

0.479

High

1080062

EZH2
Histone-lysine N-methyltransferase EZH2

1

8

High-throughput

0.479

High

1175954

ZCH18
Zinc finger CCCH domain-containing protein 18

1

8

High-throughput

0.479

High

1175955

SMC5
Structural maintenance of chromosomes protein 5

1

2

High-throughput

0.479

High

1175956

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.479

High

1175957

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1175959

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

5

High-throughput

0.479

High

1175960

PDLI5
PDZ and LIM domain protein 5

1

1

Small-scale

0.479

High

1175961

RING2
E3 ubiquitin-protein ligase RING2

1

9

High-throughput

0.479

High

1175962

DOK1
Docking protein 1

1

1

Small-scale

0.479

High

1175963

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.479

High

1175965

ANLN
Anillin

1

2

High-throughput

0.479

High

1175966

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

1043900

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

11

High-throughput

0.445

High

720767

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

1175967

X5DP20
DiGeorge syndrome critical region 6 isoform D

1

1

High-throughput

0.417

High

778196

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

0

Small-scale

0.279

Low

873443

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

0

Small-scale

0.279

Low


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Last updated: 15 Jul 2024