Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42
Interactor 2: ACK1 (Q07912)
Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2)
Gene: TNK2
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.96 | 1.00 | 0.980 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 16052498, 31871319, 20936779, 10360579, 15123659, 10684602, 11157984, 28539360, 11394904, 20086093, 24413169, 21311754 |
| Identification Methods | affinity chromatography technology, two hybrid, x-ray crystallography, pull down, fluorescent resonance energy transfer, two hybrid pooling approach, nuclear magnetic resonance |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | GTPase_binding~Ras |
| Common GO terms | GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006897 - endocytosis GO:0016020 - membrane |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
