HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: RHG01 (Q07960)
Rho GTPase-activating protein 1 (CDC42 GTPase-activating protein) (GTPase-activating protein rhoGAP) (Rho-related small GTPase protein activator) (Rho-type GTPase-activating protein 1) (p50-RhoGAP)
Gene: ARHGAP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.976

Property	Details
Experiments	14749388, 9407060, 9535855, 9427749, 10551883, 31871319, 10684602, rtd:9262406, 9846874, 9262406, 9338791
Identification Methods	pull down, two hybrid, affinity chromatography technology, x-ray crystallography
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Ras~RhoGAP
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 439
+	Hs
		564492 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		RHG01_HUMAN (1-439): 2.97e-164: 471: 100.00
+	Hs
		993069 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		RHG01_HUMAN (1-439): 2.97e-164: 471: 100.00
+	Hs
		925227 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		RHG01_HUMAN (1-439): 2.97e-164: 471: 100.00
+	Mm
		925791 RAC1_MOUSE (1-191): 1.75e-84: 249: 70.31		RHG01_MOUSE (1-439): 4.64e-163: 468: 96.58
+	Hs
		564562 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		RHG21_HUMAN (168-434): 3.18e-71: 246: 23.08
+	Hs
		564503 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		RHG05_HUMAN (148-435): 5.93e-67: 233: 20.85
+	Hs
		1133703 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		RHG21_HUMAN (168-434): 3.18e-71: 246: 23.08
+	Hs
		64652 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		RHG32_HUMAN (180-433): 7.32e-64: 225: 21.56
+	Hs
		1022689 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		RHG05_HUMAN (148-435): 5.93e-67: 233: 20.85
+	Hs
		200213 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		SRGP3_HUMAN (182-434): 2.44e-66: 231: 26.44
+	Mm
		925805 RAC1_MOUSE (1-191): 1.75e-84: 249: 70.31		RHG22_MOUSE (175-438): 2.95e-67: 229: 25.36
+	Hs
		64741 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		RHG32_HUMAN (180-433): 7.32e-64: 225: 21.56
+	Hs
		64688 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		RHG32_HUMAN (180-433): 7.32e-64: 225: 21.56
+	Hs
		147862 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		RHG33_HUMAN (164-438): 1.47e-63: 224: 22.38
+	Mm
		1194500 RHOJ_MOUSE (2-179): 1.33e-84: 250: 65.17		RHG33_MOUSE (164-438): 3.43e-63: 222: 22.38
+	Mm
		925803 RAC1_MOUSE (1-191): 1.75e-84: 249: 70.31		RHG32_MOUSE (180-435): 3.64e-63: 222: 21.40
+	Hs
		551044 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		CHIN_HUMAN (187-431): 1.89e-66: 221: 21.51
+	Mm
		925802 RAC1_MOUSE (1-191): 1.75e-84: 249: 70.31		CHIO_MOUSE (187-431): 1.39e-67: 220: 21.91
+	Hs
		856140 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		CHIO_HUMAN (187-431): 1.49e-64: 216: 21.91
+	Hs
		302639 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		FA13A_HUMAN (242-431): 1.18e-25: 112: 34.03