HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: IQGA2 (Q13576)
Ras GTPase-activating-like protein IQGAP2
Gene: IQGAP2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.963

Property	Details
Experiments	8756646, 31980649, 31478661, 31871319, 35271311, unassigned2173, 8702968
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Ras~RasGAP
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030175 - filopodium GO:0032956 - regulation of actin cytoskeleton organization and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 1575
+	Hs
		564517 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		IQGA2_HUMAN (1-1575): 0: 1336: 100.00
+	Hs
		1040058 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		IQGA2_HUMAN (1-1575): 0: 1336: 100.00
+	Hs
		925259 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		IQGA2_HUMAN (1-1575): 0: 1336: 100.00
+	Hs
		564448 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		IQGA1_HUMAN (9-1575): 0: 1223: 55.99
+	Hs
		564593 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		IQGA3_HUMAN (18-1575): 0: 1209: 47.63
+	Hs
		809436 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		IQGA1_HUMAN (9-1575): 0: 1223: 55.99
+	Hs
		809255 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		IQGA1_HUMAN (9-1575): 0: 1223: 55.99
+	Hs
		1201453 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		IQGA3_HUMAN (18-1575): 0: 1209: 47.63
+	Mm
		925821 RAC1_MOUSE (1-191): 1.75e-84: 249: 70.31		IQGA1_MOUSE (11-1575): 0: 1211: 55.45
+	Hs
		925404 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		IQGA3_HUMAN (18-1575): 0: 1209: 47.63
+	Hs
		564757 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		MYO5A_HUMAN (230-1465): 4.4e-122: 425: 12.23
+	Hs
		564412 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		NF1_HUMAN (841-1304): 1.31e-77: 287: 18.96
+	Hs
		564728 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		NGAP_HUMAN (733-1354): 3.35e-77: 282: 14.69
+	Hs
		1139212 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		DAB2P_HUMAN (733-1359): 1.86e-79: 289: 13.92
+	Hs
		598525 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		NF1_HUMAN (841-1304): 1.31e-77: 287: 18.96
+	Hs
		925347 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		DAB2P_HUMAN (733-1359): 1.86e-79: 289: 13.92
+	Hs
		598457 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		NF1_HUMAN (841-1304): 1.31e-77: 287: 18.96
+	Hs
		1330979 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		NGAP_HUMAN (733-1354): 3.35e-77: 282: 14.69
+	Hs
		925715 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		NGAP_HUMAN (733-1354): 3.35e-77: 282: 14.69
+	Hs
		925530 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		SYGP1_HUMAN (880-1392): 1.06e-73: 273: 15.61