Protein: EST1A
Telomerase-binding protein EST1A (EC 3.1.-.-) (Ever shorter telomeres 1A) (hEST1A) (Nonsense mediated mRNA decay factor SMG6) (Smg-6 homolog) (hSmg5/7a)

Gene: EST1A, SMG6
Organism: Homo sapiens
Interactions: 79
UniProt ID: Q86US8

Gene Ontology (top 5):
GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000781 - chromosome, telomeric region
GO:0003723 - RNA binding
GO:0004521 - RNA endonuclease activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1288967

SMG7
Nonsense-mediated mRNA decay factor SMG7

2

4

Small-scale

0.754

High

1288992

SMG5
Nonsense-mediated mRNA decay factor SMG5

2

4

Small-scale

0.754

High

1288968

RENT1
Regulator of nonsense transcripts 1

4

6

Small-scale

0.686

High

162947

TERT
Telomerase reverse transcriptase

2

1

Small-scale

0.624

High

995113

CSK2B
Casein kinase II subunit beta

3

0

High-throughput

0.622

High

1288962

EST1A
Telomerase-binding protein EST1A

1

4

Small-scale

0.618

High

1288975

LPIN3
Phosphatidate phosphatase LPIN3

2

0

High-throughput

0.602

High

1288985

HAOX2
2-Hydroxyacid oxidase 2

2

0

High-throughput

0.602

High

396432

ESR1
Estrogen receptor

2

0

High-throughput

0.547

High

766669

PHB1
Prohibitin 1

1

1

High-throughput

0.515

High

1232433

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.515

High

872486

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.513

High

909070

NEK4
Serine/threonine-protein kinase Nek4

1

0

High-throughput

0.513

High

948550

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.513

High

1288986

PEN2
Gamma-secretase subunit PEN-2

1

0

High-throughput

0.513

High

1288993

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

0

High-throughput

0.513

High

130977

HIP1
Huntingtin-interacting protein 1

1

0

High-throughput

0.493

High

280697

PR40A
Pre-mRNA-processing factor 40 homolog A

1

0

High-throughput

0.493

High

562176

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.493

High

937048

CASP6
Caspase-6

1

0

High-throughput

0.493

High

981564

RAN
GTP-binding nuclear protein Ran

1

0

High-throughput

0.493

High

786703

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

0

Small-scale

0.486

High

893981

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.481

High

64054

CNOT1
CCR4-NOT transcription complex subunit 1

1

1

High-throughput

0.479

High

258964

DNJA2
DnaJ homolog subfamily A member 2

1

1

High-throughput

0.479

High

273890

CNOT3
CCR4-NOT transcription complex subunit 3

1

5

High-throughput

0.479

High

290062

OFD1
Centriole and centriolar satellite protein OFD1

1

1

High-throughput

0.479

High

344734

AP2A1
AP-2 complex subunit alpha-1

1

1

High-throughput

0.479

High

352483

TOP3B
DNA topoisomerase 3-beta-1

1

1

High-throughput

0.479

High

550348

PABP1
Polyadenylate-binding protein 1

1

1

Small-scale

0.479

High

727874

DNJA1
DnaJ homolog subfamily A member 1

1

1

High-throughput

0.479

High

875705

PRC2A
Protein PRRC2A

1

7

High-throughput

0.479

High

900012

FXR1
RNA-binding protein FXR1

1

6

High-throughput

0.479

High

1206484

PRC2B
Protein PRRC2B

1

7

High-throughput

0.479

High

1280682

YTHD3
YTH domain-containing family protein 3

1

6

High-throughput

0.479

High

1288963

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

3

High-throughput

0.479

High

1288965

XRN1
5'-3' exoribonuclease 1

1

3

High-throughput

0.479

High

1288969

ASPP1
Apoptosis-stimulating of p53 protein 1

1

5

High-throughput

0.479

High

1288971

SMG1
Serine/threonine-protein kinase SMG1

1

1

High-throughput

0.479

High

1288974

ATX2
Ataxin-2

1

3

High-throughput

0.479

High

1288976

HDAC8
Histone deacetylase 8

1

2

Small-scale

0.479

High

1288977

REN3B
Regulator of nonsense transcripts 3B

1

2

Small-scale

0.479

High

1288978

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

1288979

TDRD3
Tudor domain-containing protein 3

1

2

High-throughput

0.479

High

1288981

RC3H2
Roquin-2

1

7

High-throughput

0.479

High

1288984

4ET
Eukaryotic translation initiation factor 4E transporter

1

2

High-throughput

0.479

High

1288989

AGO2
Protein argonaute-2

1

2

High-throughput

0.479

High

1288990

AGO1
Protein argonaute-1

1

2

High-throughput

0.479

High

1288994

PRC2C
Protein PRRC2C

1

6

High-throughput

0.479

High

1288995

YTHD2
YTH domain-containing family protein 2

1

6

High-throughput

0.479

High

1288996

RBM8A
RNA-binding protein 8A

1

4

Small-scale

0.479

High

124935

GTPB1
GTP-binding protein 1

1

0

High-throughput

0.458

High

331104

KI20A
Kinesin-like protein KIF20A

1

0

High-throughput

0.458

High

406345

MYCN
N-myc proto-oncogene protein

1

0

High-throughput

0.458

High

408966

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.458

High

540045

BCR
Breakpoint cluster region protein

1

0

High-throughput

0.458

High

961055

MGN
Protein mago nashi homolog

1

0

Small-scale

0.458

High

1005689

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

1

0

High-throughput

0.458

High

1045462

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1169008

CSPP1
Centrosome and spindle pole-associated protein 1

1

0

High-throughput

0.458

High

1218594

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

1288964

RTKN2
Rhotekin-2

1

0

High-throughput

0.458

High

1288966

BRX1
Ribosome biogenesis protein BRX1 homolog

1

0

High-throughput

0.458

High

1288972

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.458

High

1288980

UCK1
Uridine-cytidine kinase 1

1

0

High-throughput

0.458

High

1288982

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.458

High

1288987

IBTK
Inhibitor of Bruton tyrosine kinase

1

0

High-throughput

0.458

High

1288988

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1288991

CP131
Centrosomal protein of 131 kDa

1

0

High-throughput

0.458

High

765671

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.445

High

1288970

CC138
Coiled-coil domain-containing protein 138

1

1

High-throughput

0.437

High

1097394

CBX3
Chromobox protein homolog 3

1

0

Small-scale

0.426

High

543428

PSG1
Pregnancy-specific beta-1-glycoprotein 1

3

0

High-throughput

0.347

High

1179263

CB068
UPF0561 protein C2orf68

3

0

High-throughput

0.347

High

64462

F221B
Protein FAM221B

2

0

High-throughput

0.328

High

1219188

SPAT1
Spermatogenesis-associated protein 1

1

0

High-throughput

0.279

Low

1288973

MPP9
M-phase phosphoprotein 9

1

0

High-throughput

0.249

Low

1288983

Q9HCK3
KIAA1569 protein

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025