HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: SH319 (Q5HYK7)
SH3 domain-containing protein 19 (ADAM-binding protein Eve-1) (EEN-binding protein) (EBP)
Gene: SH3D19

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.614

Property	Details
Experiments	31871319, 20936779
Identification Methods	affinity chromatography technology, two hybrid, two hybrid pooling approach
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 191 Hs			1 790
+	Hs
		925460 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		SH3R3_HUMAN (418-723): 9.67e-28: 122: 17.33
+	Hs
		894241 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		SH3R3_HUMAN (418-723): 9.67e-28: 122: 17.33
+	Hs
		894047 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		ITSN1_HUMAN (417-786): 3.11e-27: 121: 18.20
+	Hs
		924448 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		GRB2_HUMAN (498-718): 1.8e-24: 104: 20.27
+	Hs
		209021 RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32		NCK2_HUMAN (414-652): 5.41e-28: 118: 20.36
+	Hs
		893878 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		GRB2_HUMAN (498-718): 1.8e-24: 104: 20.27
+	Hs
		1078851 RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82		ITSN1_HUMAN (417-786): 3.11e-27: 121: 18.20
+	Hs
		557724 RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82		NCK1_HUMAN (414-659): 8.08e-29: 120: 19.93
+	Hs
		209093 RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82		NCK2_HUMAN (414-652): 5.41e-28: 118: 20.36
+	Hs
		925374 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		DNMBP_HUMAN (492-785): 3.4e-16: 85.6: 17.22
+	Hs
		894149 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		DNMBP_HUMAN (492-785): 3.4e-16: 85.6: 17.22
+	Hs
		951095 RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73		DNMBP_HUMAN (492-785): 3.4e-16: 85.6: 17.22
+	Hs
		924663 RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82		GRB2_HUMAN (498-718): 1.8e-24: 104: 20.27
+	Hs
		892443 RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32		DNMBP_HUMAN (492-785): 3.4e-16: 85.6: 17.22
+	Hs
		925396 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		SH3R1_HUMAN (244-550): 1.54e-09: 63.7: 11.61
+	Hs
		925459 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		SH3R2_HUMAN (667-785): 7.09e-09: 61.2: 34.96