HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: BORG3 (Q6NZY7)
Cdc42 effector protein 5 (Binder of Rho GTPases 3)
Gene: CDC42EP5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.793

Property	Details
Experiments	11035016, 10490598
Identification Methods	pull down, two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PBD~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016020 - membrane GO:0031274 - positive regulation of pseudopodium assembly
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 191 Hs			1 148
+	Hs
		564682 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		BORG4_HUMAN (1-59): 3.63e-22: 92.1: 58.73
+	Hs
		564481 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		BORG5_HUMAN (9-65): 7.16e-19: 83.2: 59.65
+	Hs
		1330288 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		BORG4_HUMAN (1-59): 3.63e-22: 92.1: 58.73
+	Hs
		925610 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		BORG4_HUMAN (1-59): 3.63e-22: 92.1: 58.73
+	Hs
		960657 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		BORG5_HUMAN (9-65): 7.16e-19: 83.2: 59.65
+	Hs
		894420 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		BORG4_HUMAN (1-59): 3.63e-22: 92.1: 58.73
+	Hs
		951333 RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73		BORG4_HUMAN (1-59): 3.63e-22: 92.1: 58.73
+	Hs
		925198 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		BORG5_HUMAN (9-65): 7.16e-19: 83.2: 59.65
+	Hs
		900891 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		BORG4_HUMAN (1-59): 3.63e-22: 92.1: 58.73
+	Hs
		545611 RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75		BORG4_HUMAN (1-59): 3.63e-22: 92.1: 58.73
+	Hs
		893907 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		BORG5_HUMAN (9-65): 7.16e-19: 83.2: 59.65
+	Hs
		950927 RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73		BORG5_HUMAN (9-65): 7.16e-19: 83.2: 59.65
+	Hs
		892591 RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32		BORG4_HUMAN (1-59): 3.63e-22: 92.1: 58.73
+	Hs
		900382 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		BORG5_HUMAN (9-65): 7.16e-19: 83.2: 59.65
+	Hs
		545325 RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75		BORG5_HUMAN (9-65): 7.16e-19: 83.2: 59.65
+	Hs
		436256 RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41		BORG5_HUMAN (9-65): 7.16e-19: 83.2: 59.65
+	Hs
		892320 RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32		BORG5_HUMAN (9-65): 7.16e-19: 83.2: 59.65
+	Hs
		1183550 RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82		BORG4_HUMAN (1-59): 3.63e-22: 92.1: 58.73
+	Hs
		960631 RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82		BORG5_HUMAN (9-65): 7.16e-19: 83.2: 59.65