Protein: TNKS2
Poly [ADP-ribose] polymerase tankyrase-2 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 6) (ARTD6) (Poly [ADP-ribose] polymerase 5B) (Protein poly-ADP-ribosyltransferase tankyrase-2) (EC 2.4.2.-) (TNKS-2) (TRF1-interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase II) (Tankyrase-2) (TANK2) (Tankyrase-like protein) (Tankyrase-related protein)

Gene: TNKS2
Organism: Homo sapiens
Interactions: 78
UniProt ID: Q9H2K2

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0000209 - protein polyubiquitination
GO:0000242 - pericentriolar material
GO:0000781 - chromosome, telomeric region
GO:0003950 - NAD+ poly-ADP-ribosyltransferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1432021

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

5

12

Small-scale

0.934

High

1432026

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

2

11

High-throughput

0.811

High

1420040

PP12C
Protein phosphatase 1 regulatory subunit 12C

2

18

Small-scale

0.757

High

928549

TERF1
Telomeric repeat-binding factor 1

10

2

Small-scale

0.756

High

1432024

LCAP
Leucyl-cystinyl aminopeptidase

4

2

Small-scale

0.709

High

1432022

BABA1
BRISC and BRCA1-A complex member 1

4

1

Small-scale

0.708

High

177307

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

13

High-throughput

0.698

High

239336

MYPT2
Protein phosphatase 1 regulatory subunit 12B

1

19

High-throughput

0.691

High

299788

MPDZ
Multiple PDZ domain protein

1

4

High-throughput

0.691

High

1371859

CUL5
Cullin-5

1

9

High-throughput

0.691

High

1412210

S35A5
UDP-sugar transporter protein SLC35A5

4

1

High-throughput

0.691

High

1432023

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

4

7

Small-scale

0.688

High

1272915

3BP5L
SH3 domain-binding protein 5-like

3

3

Small-scale

0.667

High

1382340

RN166
E3 ubiquitin-protein ligase RNF166

3

3

High-throughput

0.667

High

1386696

AP2M1
AP-2 complex subunit mu

3

3

High-throughput

0.667

High

1431381

EPN3
Epsin-3

3

3

High-throughput

0.667

High

239206

ZNRD2
Protein ZNRD2

3

1

High-throughput

0.662

High

574035

HXB2
Homeobox protein Hox-B2

3

16

Small-scale

0.658

High

1432019

DISC1
Disrupted in schizophrenia 1 protein

3

4

Small-scale

0.658

High

703703

MK01
Mitogen-activated protein kinase 1

1

2

Small-scale

0.647

High

1060295

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

1

1

Small-scale

0.647

High

1402033

FNBP1
Formin-binding protein 1

1

4

Small-scale

0.647

High

1432018

TNKS2
Poly [ADP-ribose] polymerase tankyrase-2

1

14

Small-scale

0.647

High

1432025

TAOK2
Serine/threonine-protein kinase TAO2

1

9

Small-scale

0.647

High

1420813

TB182
182 kDa tankyrase-1-binding protein

3

19

Small-scale

0.647

High

1432020

RN146
E3 ubiquitin-protein ligase RNF146

3

1

Small-scale

0.640

High

251378

GMDS
GDP-mannose 4,6 dehydratase

2

2

High-throughput

0.628

High

1060915

LRP1
Prolow-density lipoprotein receptor-related protein 1

2

4

High-throughput

0.628

High

1292512

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

2

2

High-throughput

0.628

High

1330013

CELF5
CUGBP Elav-like family member 5

2

4

High-throughput

0.628

High

1359640

ARAP3
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

1

9

Small-scale

0.621

High

1154442

STK11
Serine/threonine-protein kinase STK11

1

1

Small-scale

0.618

High

257501

PAGE4
P antigen family member 4

2

3

High-throughput

0.611

High

1134718

NUMA1
Nuclear mitotic apparatus protein 1

2

13

Small-scale

0.606

High

949503

NANO2
Nanos homolog 2

2

0

High-throughput

0.602

High

181173

AXIN1
Axin-1

2

6

Small-scale

0.595

High

1004313

3BP2
SH3 domain-binding protein 2

2

5

Small-scale

0.593

High

320411

SASH1
SAM and SH3 domain-containing protein 1

1

0

Small-scale

0.589

High

1116799

CAC1S
Voltage-dependent L-type calcium channel subunit alpha-1S

2

5

Small-scale

0.586

High

540086

BCR
Breakpoint cluster region protein

1

12

Small-scale

0.586

High

1366822

RAD54
DNA repair and recombination protein RAD54-like

1

1

Small-scale

0.586

High

895962

F10A1
Hsc70-interacting protein

2

4

High-throughput

0.584

High

239428

3BP5
SH3 domain-binding protein 5

2

3

Small-scale

0.576

High

1240808

F117B
Protein FAM117B

2

1

High-throughput

0.574

High

1126600

GRB14
Growth factor receptor-bound protein 14

1

8

Small-scale

0.573

High

1353105

ARH40
Rho guanine nucleotide exchange factor 40

2

12

High-throughput

0.571

High

1432029

AXIN2
Axin-2

2

6

Small-scale

0.571

High

951852

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

7

Small-scale

0.561

High

1432028

AMOL2
Angiomotin-like protein 2

1

14

Small-scale

0.561

High

228628

STRN
Striatin

1

6

Small-scale

0.550

High

248778

PEPL
Periplakin

1

20

High-throughput

0.536

High

640288

EPHA1
Ephrin type-A receptor 1

1

8

High-throughput

0.528

High

1387554

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

10

High-throughput

0.515

High

1278104

MAVS
Mitochondrial antiviral-signaling protein

1

11

Small-scale

0.512

High

1210987

CE170
Centrosomal protein of 170 kDa

1

15

Small-scale

0.501

High

1307486

MY18B
Unconventional myosin-XVIIIb

1

7

Small-scale

0.501

High

1413311

DIDO1
Death-inducer obliterator 1

1

10

Small-scale

0.501

High

1400301

CC85A
Coiled-coil domain-containing protein 85A

1

1

High-throughput

0.489

High

1406310

CGRE1
Cell growth regulator with EF hand domain protein 1

1

1

High-throughput

0.489

High

1410448

SOST
Sclerostin

1

1

High-throughput

0.489

High

1129742

MDC1
Mediator of DNA damage checkpoint protein 1

1

14

Small-scale

0.481

High

808168

CDN1A
Cyclin-dependent kinase inhibitor 1

1

2

Small-scale

0.479

High

1197085

AMOT
Angiomotin

1

14

Small-scale

0.479

High

1227442

A16L1
Autophagy-related protein 16-1

1

11

Small-scale

0.479

High

1314103

AMOL1
Angiomotin-like protein 1

1

18

Small-scale

0.479

High

1365592

MY18A
Unconventional myosin-XVIIIa

1

8

High-throughput

0.479

High

1402297

RANB9
Ran-binding protein 9

1

2

High-throughput

0.479

High

1419399

IFIH1
Interferon-induced helicase C domain-containing protein 1

1

1

Small-scale

0.479

High

1396129

Z512B
Zinc finger protein 512B

1

5

High-throughput

0.464

High

1250366

FAT4
Protocadherin Fat 4

1

1

Small-scale

0.457

High

1290968

TAXB1
Tax1-binding protein 1

1

9

Small-scale

0.457

High

1431860

GO45
Golgin-45

1

1

High-throughput

0.445

High

1432027

SL9A8
Sodium/hydrogen exchanger 8

1

2

High-throughput

0.445

High

1022275

FBLN2
Fibulin-2

1

9

Small-scale

0.417

High

1280155

ARPIN
Arpin

1

0

Small-scale

0.295

High

1125321

FASTK
Fas-activated serine/threonine kinase

1

0

Small-scale

0.261

Low

947050

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025