HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: UNC5B (Q8IZJ1)
Netrin receptor UNC5B (Protein unc-5 homolog 2) (Protein unc-5 homolog B) (p53-regulated receptor for death and life protein 1) (p53RDL1)
Gene: UNC5B

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 191 Hs			1 945
+	Hs
		564606 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		UNC5B_HUMAN (1-945): 0: 962: 100.00
+	Hs
		1224470 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		UNC5B_HUMAN (1-945): 0: 962: 100.00
+	Hs
		925426 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		UNC5B_HUMAN (1-945): 0: 962: 100.00
+	Hs
		900676 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		UNC5B_HUMAN (1-945): 0: 962: 100.00
+	Hs
		892478 RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32		UNC5B_HUMAN (1-945): 0: 962: 100.00
+	Hs
		1183457 RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82		UNC5B_HUMAN (1-945): 0: 962: 100.00
+	Hs
		893933 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		ZO1_HUMAN (405-656): 2.76e-51: 198: 20.63
+	Hs
		900411 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		ZO1_HUMAN (405-656): 2.76e-51: 198: 20.63
+	Hs
		564764 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		ROBO1_HUMAN (2-257): 1.06e-41: 168: 17.16
+	Hs
		1331019 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		ROBO1_HUMAN (2-257): 1.06e-41: 168: 17.16
+	Hs
		925776 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		ROBO1_HUMAN (2-257): 1.06e-41: 168: 17.16
+	Hs
		894644 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		ROBO1_HUMAN (2-257): 1.06e-41: 168: 17.16
+	Hs
		894276 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		PXDN_HUMAN (2-262): 8.33e-41: 165: 17.80
+	Hs
		901110 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		ROBO1_HUMAN (2-257): 1.06e-41: 168: 17.16
+	Hs
		436602 RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41		ROBO1_HUMAN (2-257): 1.06e-41: 168: 17.16
+	Hs
		1183635 RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82		ROBO1_HUMAN (2-257): 1.06e-41: 168: 17.16
+	Hs
		1166654 RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82		LRIG3_HUMAN (11-263): 1.61e-38: 157: 19.23
+	Hs
		894044 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		MYLK_HUMAN (37-133): 4.45e-11: 69.3: 13.00