HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: AGAP1 (Q9UPQ3)
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 (AGAP-1) (Centaurin-gamma-2) (Cnt-g2) (GTP-binding and GTPase-activating protein 1) (GGAP1)
Gene: AGAP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22453919
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ank_2~Ras, Ras~Ras
Common GO terms	GO:0003924 - GTPase activity GO:0005525 - GTP binding GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 857
+	Hs
		925736 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		AGAP1_HUMAN (1-857): 0: 850: 100.00
+	Hs
		925551 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		AGAP2_HUMAN (52-827): 0: 597: 52.94
+	Mm
		892722 CDC42_MOUSE (1-191): 4.96e-82: 243: 100.00		AGAP2_MOUSE (53-827): 0: 579: 52.95
+	Hs
		925724 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		ASAP1_HUMAN (367-855): 1.34e-86: 300: 20.87
+	Hs
		564527 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		GIT2_HUMAN (616-823): 7.46e-74: 258: 33.33
+	Hs
		564752 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		GIT1_HUMAN (616-848): 2.84e-73: 257: 31.58
+	Hs
		925478 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		ARAP2_HUMAN (556-846): 2.29e-75: 271: 27.70
+	Hs
		1050152 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		GIT2_HUMAN (616-823): 7.46e-74: 258: 33.33
+	Hs
		1331002 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		GIT1_HUMAN (616-848): 2.84e-73: 257: 31.58
+	Gg
		1154344 Q6LC82_CHICK (1-191): 1.75e-84: 249: 70.31		Q9DG15_CHICK (622-848): 1.04e-73: 258: 32.78
+	Hs
		925274 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		GIT2_HUMAN (616-823): 7.46e-74: 258: 33.33
+	Hs
		925751 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		GIT1_HUMAN (616-848): 2.84e-73: 257: 31.58
+	Hs
		564470 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		RAB1A_HUMAN (72-257): 3.27e-72: 237: 24.35
+	Hs
		564467 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		RAP1B_HUMAN (69-229): 7.97e-70: 230: 22.75
+	Hs
		918948 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		RAB1A_HUMAN (72-257): 3.27e-72: 237: 24.35
+	Hs
		918847 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		RAB1A_HUMAN (72-257): 3.27e-72: 237: 24.35
+	Hs
		897952 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		RAP1B_HUMAN (69-229): 7.97e-70: 230: 22.75
+	Hs
		893872 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		RAB1A_HUMAN (72-257): 3.27e-72: 237: 24.35
+	Hs
		897878 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		RAP1B_HUMAN (69-229): 7.97e-70: 230: 22.75
+	Hs
		893855 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		RAP1B_HUMAN (69-229): 7.97e-70: 230: 22.75