HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: GIT1 (Q9Y2X7)
ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1)
Gene: GIT1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.834

Property	Details
Experiments	31478661, 31871319, 36963288
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Ank_2~Ras
Common GO terms	GO:0005813 - centrosome GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0016020 - membrane GO:0043005 - neuron projection
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 761
+	Hs
		564752 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		GIT1_HUMAN (1-761): 1.3e-176: 527: 100.00
+	Hs
		1331002 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		GIT1_HUMAN (1-761): 1.3e-176: 527: 100.00
+	Hs
		925751 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		GIT1_HUMAN (1-761): 1.3e-176: 527: 100.00
+	Gg
		1154344 Q6LC82_CHICK (1-191): 1.75e-84: 249: 70.31		Q9DG15_CHICK (1-761): 2.03e-155: 471: 85.41
+	Hs
		564527 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		GIT2_HUMAN (1-758): 2.93e-147: 451: 64.39
+	Hs
		1050152 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		GIT2_HUMAN (1-758): 2.93e-147: 451: 64.39
+	Hs
		925274 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		GIT2_HUMAN (1-758): 2.93e-147: 451: 64.39
+	Hs
		894000 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		GIT2_HUMAN (1-758): 2.93e-147: 451: 64.39
+	Hs
		925724 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		ASAP1_HUMAN (2-606): 1.67e-61: 226: 17.06
+	Hs
		925736 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		AGAP1_HUMAN (2-223): 4.13e-57: 211: 32.89
+	Hs
		925423 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		HACE1_HUMAN (134-500): 3.45e-54: 203: 15.80
+	Hs
		925551 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		AGAP2_HUMAN (2-223): 3.67e-52: 198: 32.00
+	Hs
		925478 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		ARAP2_HUMAN (7-223): 6.18e-51: 195: 27.15
+	Hs
		894263 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		ARAP2_HUMAN (7-223): 6.18e-51: 195: 27.15
+	Hs
		925529 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		ARAP1_HUMAN (8-205): 6.26e-49: 188: 29.35
+	Mm
		892722 CDC42_MOUSE (1-191): 4.96e-82: 243: 100.00		AGAP2_MOUSE (2-223): 9.71e-49: 188: 29.28
+	Hs
		894325 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		ARAP1_HUMAN (8-205): 6.26e-49: 188: 29.35
+	Hs
		925238 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		ANK3_HUMAN (93-695): 4.85e-40: 162: 12.34
+	Hs
		893947 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		ANK3_HUMAN (93-695): 4.85e-40: 162: 12.34
+	Hs
		925204 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		ANK2_HUMAN (162-494): 7.25e-30: 129: 9.52