HitPredict

Interactor 1: RAB8A (P61006)
Ras-related protein Rab-8A (EC 3.6.5.2) (Oncogene c-mel)
Gene: RAB8A

Interactor 2: MICA1 (Q8TDZ2)
[F-actin]-monooxygenase MICAL1 (EC 1.14.13.225) (EC 1.6.3.1) (Molecule interacting with CasL protein 1) (MICAL-1) (NEDD9-interacting protein with calponin homology and LIM domains)
Gene: MICAL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.735

Property	Details
Experiments	26824392, 29125462
Identification Methods	anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Ras~bMERB_dom
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0010008 - endosome membrane GO:0030496 - midbody GO:0031267 - small GTPase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 207 Hs			1 1067
+	Hs
		895525 RAB10_HUMAN (3-181): 4.07e-93: 272: 75.98		MICA1_HUMAN (1-1067): 0: 1251: 100.00
+	Hs
		918915 RAB1A_HUMAN (1-204): 1.23e-87: 258: 54.41		MICA1_HUMAN (1-1067): 0: 1251: 100.00
+	Hs
		1255762 RAB1B_HUMAN (1-204): 7.39e-87: 256: 51.96		MICA1_HUMAN (1-1067): 0: 1251: 100.00
+	Mm
		292526 RAB10_MOUSE (3-181): 4.07e-93: 272: 75.98		ACTN3_MOUSE (430-1064): 8.36e-128: 413: 12.40
+	Hs
		914014 RB11A_HUMAN (4-204): 5.02e-81: 242: 41.06		SPTB2_HUMAN (430-1064): 4.18e-110: 380: 14.93
+	Ce
		105523 RAB10_CAEEL (1-204): 1.51e-86: 255: 68.29		G5ECW3_CAEEL (428-1061): 1.65e-85: 298: 14.50
+	Ce
		105521 G5EFC1_CAEEL (1-207): 9.93e-82: 243: 70.62		G5ECW3_CAEEL (428-1061): 1.65e-85: 298: 14.50
+	Mm
		1112011 RAB13_MOUSE (1-206): 2.37e-89: 262: 62.62		MILK2_MOUSE (752-1059): 1.29e-50: 196: 19.32
+	Hs
		895513 RAB10_HUMAN (3-181): 4.07e-93: 272: 75.98		MILK1_HUMAN (769-1051): 2.84e-43: 172: 21.68
+	Hs
		845867 RAB13_HUMAN (1-206): 3.19e-89: 262: 61.17		MILK2_HUMAN (748-1059): 8.81e-46: 180: 19.44
+	Hs
		894763 RAB8A_HUMAN (1-207): 1.67e-86: 255: 100.00		MILK2_HUMAN (748-1059): 8.81e-46: 180: 19.44
+	Hs
		845869 RAB13_HUMAN (1-206): 3.19e-89: 262: 61.17		MILK1_HUMAN (769-1051): 2.84e-43: 172: 21.68
+	Hs
		1222038 RAB8B_HUMAN (1-207): 6.41e-86: 253: 82.61		MILK2_HUMAN (748-1059): 8.81e-46: 180: 19.44
+	Hs
		894773 RAB8A_HUMAN (1-207): 1.67e-86: 255: 100.00		EHBP1_HUMAN (636-1055): 4.42e-44: 176: 13.41
+	Hs
		894767 RAB8A_HUMAN (1-207): 1.67e-86: 255: 100.00		MILK1_HUMAN (769-1051): 2.84e-43: 172: 21.68
+	Hs
		1232324 RAB8B_HUMAN (1-207): 6.41e-86: 253: 82.61		MILK1_HUMAN (769-1051): 2.84e-43: 172: 21.68
+	Hs
		895507 RAB10_HUMAN (3-181): 4.07e-93: 272: 75.98		MICA3_HUMAN (582-1053): 3.46e-30: 131: 19.03
+	Hs
		894754 RAB8A_HUMAN (1-207): 1.67e-86: 255: 100.00		MICA3_HUMAN (582-1053): 3.46e-30: 131: 19.03
+	Hs
		1186079 RAB8B_HUMAN (1-207): 6.41e-86: 253: 82.61		MICA3_HUMAN (582-1053): 3.46e-30: 131: 19.03
+	Hs
		914166 RB11A_HUMAN (4-204): 5.02e-81: 242: 41.06		MICA3_HUMAN (582-1053): 3.46e-30: 131: 19.03