Protein: CP2C9
Cytochrome P450 2C9 (EC 1.14.14.1) ((R)-limonene 6-monooxygenase) (EC 1.14.14.53) ((S)-limonene 6-monooxygenase) (EC 1.14.14.51) ((S)-limonene 7-monooxygenase) (EC 1.14.14.52) (CYPIIC9) (Cholesterol 25-hydroxylase) (Cytochrome P-450MP) (Cytochrome P450 MP-4) (Cytochrome P450 MP-8) (Cytochrome P450 PB-1) (S-mephenytoin 4-hydroxylase)

Gene: CP2C9, CYP2C9
Organism: Homo sapiens
Interactions: 103
UniProt ID: P11712

Gene Ontology (top 5):
GO:0004497 - monooxygenase activity
GO:0005506 - iron ion binding
GO:0005737 - cytoplasm
GO:0005789 - endoplasmic reticulum membrane
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

548316

CP2CI
Cytochrome P450 2C18

3

12

High-throughput

0.861

High

548310

NCPR
NADPH--cytochrome P450 reductase

3

6

Small-scale

0.840

High

548317

CP2CJ
Cytochrome P450 2C19

2

11

High-throughput

0.811

High

475182

CP3A4
Cytochrome P450 3A4

1

11

Small-scale

0.647

High

528931

CP2D6
Cytochrome P450 2D6

1

12

Small-scale

0.647

High

548319

AGRE5
Adhesion G protein-coupled receptor E5

2

2

High-throughput

0.628

High

548386

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

4

High-throughput

0.541

High

340610

STABP
STAM-binding protein

1

0

High-throughput

0.518

High

343167

RAB3D
Ras-related protein Rab-3D

1

0

High-throughput

0.518

High

548337

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.518

High

548369

RNF32
RING finger protein 32

1

1

High-throughput

0.494

High

548338

RA1L2
Heterogeneous nuclear ribonucleoprotein A1-like 2

1

0

High-throughput

0.493

High

548384

SSRG
Translocon-associated protein subunit gamma

1

0

High-throughput

0.493

High

548366

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

2

High-throughput

0.481

High

129972

PGRC1
Membrane-associated progesterone receptor component 1

1

9

High-throughput

0.479

High

181243

PGRC2
Membrane-associated progesterone receptor component 2

1

9

High-throughput

0.479

High

192179

YKT6
Synaptobrevin homolog YKT6

1

1

High-throughput

0.479

High

280106

SC22B
Vesicle-trafficking protein SEC22b

1

1

High-throughput

0.479

High

280994

TACC1
Transforming acidic coiled-coil-containing protein 1

1

1

High-throughput

0.479

High

295791

FACE1
CAAX prenyl protease 1 homolog

1

1

High-throughput

0.479

High

320934

SUN1
SUN domain-containing protein 1

1

1

High-throughput

0.479

High

332844

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

1

High-throughput

0.479

High

548312

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

1

High-throughput

0.479

High

548313

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

3

High-throughput

0.479

High

548315

HMOX2
Heme oxygenase 2

1

1

High-throughput

0.479

High

548324

S12A2
Solute carrier family 12 member 2

1

1

High-throughput

0.479

High

548326

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.479

High

548332

STIM1
Stromal interaction molecule 1

1

1

High-throughput

0.479

High

548333

ITPR2
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2

1

1

High-throughput

0.479

High

548334

ITPR3
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3

1

1

High-throughput

0.479

High

548336

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

1

High-throughput

0.479

High

548348

VRK2
Serine/threonine-protein kinase VRK2

1

3

High-throughput

0.479

High

548349

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

1

High-throughput

0.479

High

548350

LRC49
Leucine-rich repeat-containing protein 49

1

1

High-throughput

0.479

High

548353

PDZD8
PDZ domain-containing protein 8

1

1

High-throughput

0.479

High

548357

UBXN4
UBX domain-containing protein 4

1

1

High-throughput

0.479

High

548362

DNJC1
DnaJ homolog subfamily C member 1

1

1

High-throughput

0.479

High

548367

ESYT1
Extended synaptotagmin-1

1

1

High-throughput

0.479

High

548371

WDR41
WD repeat-containing protein 41

1

1

High-throughput

0.479

High

548373

SEC12
Guanine nucleotide-exchange factor SEC12

1

2

High-throughput

0.479

High

548378

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

548379

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.479

High

548380

STIM2
Stromal interaction molecule 2

1

1

High-throughput

0.479

High

548381

STX18
Syntaxin-18

1

1

High-throughput

0.479

High

548388

UB2J1
Ubiquitin-conjugating enzyme E2 J1

1

4

High-throughput

0.479

High

548318

STA5A
Signal transducer and activator of transcription 5A

1

0

High-throughput

0.460

High

65550

TBAL3
Tubulin alpha chain-like 3

1

0

High-throughput

0.458

High

133426

ACATN
Acetyl-coenzyme A transporter 1

1

0

High-throughput

0.458

High

175313

PLXB2
Plexin-B2

1

0

High-throughput

0.458

High

250042

ADCY9
Adenylate cyclase type 9

1

0

High-throughput

0.458

High

258228

TRI13
E3 ubiquitin-protein ligase TRIM13

1

0

High-throughput

0.458

High

329506

STBD1
Starch-binding domain-containing protein 1

1

0

High-throughput

0.458

High

339412

ACSL3
Fatty acid CoA ligase Acsl3

1

0

High-throughput

0.458

High

417236

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

468978

SRPRA
Signal recognition particle receptor subunit alpha

1

0

High-throughput

0.458

High

548314

CALX
Calnexin

1

0

High-throughput

0.458

High

548320

CAMLG
Guided entry of tail-anchored proteins factor CAMLG

1

0

High-throughput

0.458

High

548321

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.458

High

548322

EMD
Emerin

1

0

High-throughput

0.458

High

548323

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

0

High-throughput

0.458

High

548328

CKAP4
Cytoskeleton-associated protein 4

1

0

High-throughput

0.458

High

548329

STX5
Syntaxin-5

1

0

High-throughput

0.458

High

548331

PHLP
Phosducin-like protein

1

0

High-throughput

0.458

High

548335

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

548340

TGO1
Transport and Golgi organization protein 1 homolog

1

0

High-throughput

0.458

High

548342

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

1

0

High-throughput

0.458

High

548344

TPGS1
Tubulin polyglutamylase complex subunit 1

1

0

High-throughput

0.458

High

548345

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.458

High

548346

KTN1
Kinectin

1

0

High-throughput

0.458

High

548347

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

0

High-throughput

0.458

High

548351

VMA12
Vacuolar ATPase assembly protein VMA12

1

0

High-throughput

0.458

High

548355

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

0

High-throughput

0.458

High

548356

SYNE2
Nesprin-2

1

0

High-throughput

0.458

High

548358

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.458

High

548359

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

548361

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

548363

TRPM7
Transient receptor potential cation channel subfamily M member 7

1

0

High-throughput

0.458

High

548364

CLCC1
Chloride channel CLIC-like protein 1

1

0

High-throughput

0.458

High

548368

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.458

High

548372

VEZA
Vezatin

1

0

High-throughput

0.458

High

548374

AT131
Endoplasmic reticulum transmembrane helix translocase

1

0

High-throughput

0.458

High

548375

JPH1
Junctophilin-1

1

0

High-throughput

0.458

High

548377

NSMA3
Sphingomyelin phosphodiesterase 4

1

0

High-throughput

0.458

High

548382

DHCR7
7-dehydrocholesterol reductase

1

0

High-throughput

0.458

High

548385

FND3A
Fibronectin type-III domain-containing protein 3A

1

0

High-throughput

0.458

High

548389

SRPRB
Signal recognition particle receptor subunit beta

1

0

High-throughput

0.458

High

548390

S23IP
SEC23-interacting protein

1

0

High-throughput

0.458

High

548311

PRS6A
26S proteasome regulatory subunit 6A

1

2

High-throughput

0.437

High

548339

RABL3
Rab-like protein 3

1

1

High-throughput

0.437

High

548360

FAF2
FAS-associated factor 2

1

1

High-throughput

0.437

High

354289

TOM40
Mitochondrial import receptor subunit TOM40 homolog

2

0

High-throughput

0.328

High

548325

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

High-throughput

0.249

Low

548327

RBM11
Splicing regulator RBM11

1

0

High-throughput

0.249

Low

548330

PDE3B
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

1

0

High-throughput

0.249

Low

548341

TOIP1
Torsin-1A-interacting protein 1

1

0

High-throughput

0.249

Low

548343

ZCHC8
Zinc finger CCHC domain-containing protein 8

1

0

High-throughput

0.249

Low

548352

MACOI
Macoilin

1

0

High-throughput

0.249

Low

548354

NPL4
Nuclear protein localization protein 4 homolog

1

0

High-throughput

0.249

Low

548365

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

0

High-throughput

0.249

Low

548370

IFG15
Torsin-1A-interacting protein 2, isoform IFRG15

1

0

High-throughput

0.249

Low

548376

ARFG3
ADP-ribosylation factor GTPase-activating protein 3

1

0

High-throughput

0.249

Low

548383

SEC63
Translocation protein SEC63 homolog

1

0

High-throughput

0.249

Low

548387

MAN1
Inner nuclear membrane protein Man1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025