HitPredict

Interactor 1: RAB5B (P61020)
Ras-related protein Rab-5B (EC 3.6.5.2)
Gene: RAB5B

Interactor 2: OPTN (Q96CV9)
Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)
Gene: OPTN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31723608
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005794 - Golgi apparatus
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 215 Hs			1 577
+	Hs
		1287377 RAB1B_HUMAN (13-213): 4.44e-89: 262: 39.30		OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00
+	Hs
		914277 RB11A_HUMAN (10-215): 2.59e-86: 255: 38.61		OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00
+	Hs
		894791 RAB8A_HUMAN (14-211): 1.25e-85: 253: 34.85		OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00
+	Hs
		1079953 RB11B_HUMAN (10-215): 3.73e-85: 252: 39.63		OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00
+	Mm
		914516 RB11A_MOUSE (10-215): 2.59e-86: 255: 38.61		OPTN_MOUSE (1-577): 1.53e-43: 165: 75.80
+	Hs
		914503 RB11A_HUMAN (10-215): 2.59e-86: 255: 38.61		NEMO_HUMAN (204-576): 1.98e-39: 150: 25.86
+	Hs
		894836 RAB8A_HUMAN (14-211): 1.25e-85: 253: 34.85		NEMO_HUMAN (204-576): 1.98e-39: 150: 25.86
+	Hs
		1079980 RB11B_HUMAN (10-215): 3.73e-85: 252: 39.63		NEMO_HUMAN (204-576): 1.98e-39: 150: 25.86
+	Hs
		592275 RAB5A_HUMAN (1-215): 9.46e-89: 262: 81.86		ITSN1_HUMAN (160-551): 1.63e-27: 120: 14.90
+	Hs
		914091 RB11A_HUMAN (10-215): 2.59e-86: 255: 38.61		ITSN1_HUMAN (160-551): 1.63e-27: 120: 14.90
+	Hs
		894733 RAB8A_HUMAN (14-211): 1.25e-85: 253: 34.85		DCTN1_HUMAN (199-553): 3.22e-27: 119: 17.58
+	Dm
		1001875 RAB5_DROME (3-213): 2.42e-97: 283: 72.51		Q0KI67_DROME (11-511): 1.3e-10: 66.6: 14.34
+	Hs
		148636 RAB1A_HUMAN (10-213): 8.59e-91: 266: 39.51		CTRO_HUMAN (7-564): 1.03e-13: 76.6: 11.59
+	Hs
		148389 RAB5A_HUMAN (1-215): 9.46e-89: 262: 81.86		CTRO_HUMAN (7-564): 1.03e-13: 76.6: 11.59
+	Hs
		149274 RAB1B_HUMAN (13-213): 4.44e-89: 262: 39.30		CTRO_HUMAN (7-564): 1.03e-13: 76.6: 11.59
+	Hs
		914103 RB11A_HUMAN (10-215): 2.59e-86: 255: 38.61		GRDN_HUMAN (5-456): 8.11e-14: 77.2: 9.37
+	Hs
		914383 RB11A_HUMAN (10-215): 2.59e-86: 255: 38.61		MYO5C_HUMAN (39-462): 1.18e-12: 73.1: 14.87
+	Hs
		894813 RAB8A_HUMAN (14-211): 1.25e-85: 253: 34.85		MYO5C_HUMAN (39-462): 1.18e-12: 73.1: 14.87
+	Hs
		254466 RB11A_HUMAN (10-215): 2.59e-86: 255: 38.61		ROCK2_HUMAN (1-323): 2.95e-11: 68.7: 10.22