Protein: VSIG4
V-set and immunoglobulin domain-containing protein 4 (Protein Z39Ig)

Gene: VSIG4
Organism: Homo sapiens
Interactions: 230
UniProt ID: Q9Y279

Gene Ontology (top 5):
GO:0001851 - complement component C3b binding
GO:0006957 - complement activation, alternative pathway
GO:0016020 - membrane
GO:0032703 - negative regulation of interleukin-2 production
GO:0032991 - protein-containing complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

321792

AGRL1
Adhesion G protein-coupled receptor L1

4

2

High-throughput

0.892

High

1490559

ORNT1
Mitochondrial ornithine transporter 1

4

6

High-throughput

0.892

High

552448

ADT3
ADP/ATP translocase 3

3

3

High-throughput

0.861

High

1461567

KDIS
Kinase D-interacting substrate of 220 kDa

3

5

High-throughput

0.861

High

1023406

AT2C1
Calcium-transporting ATPase type 2C member 1

2

5

High-throughput

0.789

High

839411

MTOR
Serine/threonine-protein kinase mTOR

2

9

High-throughput

0.776

High

844899

EAA1
Excitatory amino acid transporter 1

2

4

High-throughput

0.776

High

908893

NEK3
Serine/threonine-protein kinase Nek3

3

5

High-throughput

0.770

High

1032677

AT2B2
Plasma membrane calcium-transporting ATPase 2

3

3

High-throughput

0.770

High

1243074

PKN3
Serine/threonine-protein kinase N3

3

2

High-throughput

0.770

High

411125

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

20

High-throughput

0.737

High

1414852

SCMC3
Mitochondrial adenyl nucleotide antiporter SLC25A23

2

4

High-throughput

0.726

High

337845

SGPL1
Sphingosine-1-phosphate lyase 1

3

0

High-throughput

0.720

High

839520

PI4KA
Phosphatidylinositol 4-kinase alpha

2

3

High-throughput

0.712

High

162060

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

2

1

High-throughput

0.705

High

332258

UCP5
Brain mitochondrial carrier protein 1

2

3

High-throughput

0.705

High

902236

RAB13
Ras-related protein Rab-13

2

4

High-throughput

0.705

High

912730

CTR2
Cationic amino acid transporter 2

2

6

High-throughput

0.705

High

1206351

WDR44
WD repeat-containing protein 44

2

4

High-throughput

0.705

High

1335580

DGLB
Diacylglycerol lipase-beta

2

1

High-throughput

0.705

High

1438683

PCDH9
Protocadherin-9

2

7

High-throughput

0.705

High

269074

ABCB7
Iron-sulfur clusters transporter ABCB7, mitochondrial

2

3

High-throughput

0.694

High

1435249

ANTR1
Anthrax toxin receptor 1

2

2

High-throughput

0.694

High

211959

SPIT1
Kunitz-type protease inhibitor 1

1

6

High-throughput

0.691

High

661345

AT2B4
Plasma membrane calcium-transporting ATPase 4

1

6

High-throughput

0.691

High

787269

BMR1A
Bone morphogenetic protein receptor type-1A

1

1

High-throughput

0.691

High

845163

EAA3
Excitatory amino acid transporter 3

1

4

High-throughput

0.691

High

944962

RAB38
Ras-related protein Rab-38

1

11

High-throughput

0.691

High

1083212

GALT1
Polypeptide N-acetylgalactosaminyltransferase 1

1

3

High-throughput

0.691

High

1432221

SPNS1
Protein spinster homolog 1

1

1

High-throughput

0.691

High

1438417

S38AA
Solute carrier family 38 member 10

1

1

High-throughput

0.691

High

1462625

XCT
Cystine/glutamate transporter

1

6

High-throughput

0.691

High

1490563

S4A7
Sodium bicarbonate cotransporter 3

1

2

High-throughput

0.691

High

369936

CO3
Complement C3

1

2

Small-scale

0.690

High

699901

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

3

11

High-throughput

0.667

High

225393

ERD23
ER lumen protein-retaining receptor 3

2

0

High-throughput

0.660

High

567788

TF
Tissue factor

1

0

High-throughput

0.656

High

423485

A4
Amyloid-beta precursor protein

1

8

High-throughput

0.647

High

1393591

INT4
Integrator complex subunit 4

4

1

High-throughput

0.630

High

1450529

INT7
Integrator complex subunit 7

4

1

High-throughput

0.630

High

170550

RAB7L
Ras-related protein Rab-7L1

1

14

High-throughput

0.618

High

194856

KCNN4
Intermediate conductance calcium-activated potassium channel protein 4

1

2

High-throughput

0.618

High

690138

AVR2A
Activin receptor type-2A

1

1

High-throughput

0.618

High

931315

AT12A
Potassium-transporting ATPase alpha chain 2

1

4

High-throughput

0.618

High

1062198

PCDH1
Protocadherin-1

1

6

High-throughput

0.618

High

1063029

DDR1
Epithelial discoidin domain-containing receptor 1

1

17

High-throughput

0.618

High

1160934

PRSS8
Prostasin

1

3

High-throughput

0.618

High

1177209

MICB
MHC class I polypeptide-related sequence B

1

6

High-throughput

0.618

High

1210710

KMCP1
Kidney mitochondrial carrier protein 1

1

3

High-throughput

0.618

High

1249744

SE6L2
Seizure 6-like protein 2

1

1

High-throughput

0.618

High

1272632

PCAT2
Lysophosphatidylcholine acyltransferase 2

1

4

High-throughput

0.618

High

1322679

RPTOR
Regulatory-associated protein of mTOR

1

8

High-throughput

0.618

High

1347170

WDR48
WD repeat-containing protein 48

1

4

High-throughput

0.618

High

1406220

OSMR
Oncostatin-M-specific receptor subunit beta

1

13

High-throughput

0.618

High

1413594

LRFN3
Leucine-rich repeat and fibronectin type-III domain-containing protein 3

1

13

High-throughput

0.618

High

1420079

KPCD2
Serine/threonine-protein kinase D2

1

3

High-throughput

0.618

High

1438544

TPC
Mitochondrial thiamine pyrophosphate carrier

1

5

High-throughput

0.618

High

1445841

ABCB6
ATP-binding cassette sub-family B member 6

1

3

High-throughput

0.618

High

1454256

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

13

High-throughput

0.618

High

1490555

TBL2
Transducin beta-like protein 2

1

4

High-throughput

0.618

High

350267

FADS2
Acyl-CoA 6-desaturase

1

1

High-throughput

0.618

High

1034087

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

1

High-throughput

0.618

High

1453394

MTCH1
Mitochondrial carrier homolog 1

1

8

High-throughput

0.618

High

1386803

GCP3
Gamma-tubulin complex component 3

2

1

High-throughput

0.611

High

732861

GLPK
Glycerol kinase

3

1

High-throughput

0.609

High

1364943

AP3S1
AP-3 complex subunit sigma-1

3

1

High-throughput

0.609

High

1435083

ZDHC6
Palmitoyltransferase ZDHHC6

3

2

High-throughput

0.609

High

1454077

SH3B4
SH3 domain-binding protein 4

3

1

High-throughput

0.609

High

1458413

S53A1
Solute carrier family 53 member 1

3

1

High-throughput

0.609

High

1233677

DRS7B
Dehydrogenase/reductase SDR family member 7B

2

3

High-throughput

0.601

High

1288679

GPAT4
Glycerol-3-phosphate acyltransferase 4

2

3

High-throughput

0.601

High

1439538

AT131
Endoplasmic reticulum transmembrane helix translocase

2

6

High-throughput

0.601

High

1490561

BIG2
Brefeldin A-inhibited guanine nucleotide-exchange protein 2

2

7

High-throughput

0.601

High

1147588

UBE3C
Ubiquitin-protein ligase E3C

3

5

High-throughput

0.593

High

1246036

ZNT9
Proton-coupled zinc antiporter SLC30A9, mitochondrial

3

4

High-throughput

0.593

High

163368

TR10B
Tumor necrosis factor receptor superfamily member 10B

1

0

High-throughput

0.578

High

834701

TNFL9
Tumor necrosis factor ligand superfamily member 9

1

0

High-throughput

0.578

High

1391870

AURKB
Aurora kinase B

1

0

High-throughput

0.578

High

1398995

ZN558
Zinc finger protein 558

1

0

High-throughput

0.578

High

1461885

TMCO1
Calcium load-activated calcium channel

1

0

High-throughput

0.578

High

1224791

RN213
E3 ubiquitin-protein ligase RNF213

2

0

High-throughput

0.576

High

1357051

S20A1
Sodium-dependent phosphate transporter 1

2

0

High-throughput

0.576

High

1434483

ALG2
Alpha-1,3/1,6-mannosyltransferase ALG2

2

0

High-throughput

0.576

High

228113

PM34
Peroxisomal membrane protein PMP34

1

7

High-throughput

0.575

High

895373

S26A2
Sulfate transporter

1

1

High-throughput

0.575

High

1316787

WDFY3
WD repeat and FYVE domain-containing protein 3

1

7

High-throughput

0.575

High

1395505

PCD16
Protocadherin-16

1

4

High-throughput

0.575

High

1417368

S26A6
Solute carrier family 26 member 6

1

1

High-throughput

0.575

High

1446382

IL1AP
Interleukin-1 receptor accessory protein

1

13

High-throughput

0.575

High

1462163

PCDGK
Protocadherin gamma-C3

1

3

High-throughput

0.575

High

1462176

PCDGG
Protocadherin gamma-B4

1

4

High-throughput

0.575

High

1490556

PCDBB
Protocadherin beta-11

1

3

High-throughput

0.575

High

637983

NF1
Neurofibromin

2

5

High-throughput

0.571

High

1410291

KLDC3
Kelch domain-containing protein 3

2

3

High-throughput

0.558

High

328763

VAMP5
Vesicle-associated membrane protein 5

2

2

High-throughput

0.553

High

1328227

JAGN1
Protein jagunal homolog 1

2

1

High-throughput

0.553

High

138343

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

2

High-throughput

0.553

High

777797

VGFR3
Vascular endothelial growth factor receptor 3

1

16

High-throughput

0.553

High

1195714

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

1

High-throughput

0.553

High

1336139

GLT11
Polypeptide N-acetylgalactosaminyltransferase 11

1

3

High-throughput

0.553

High

1420863

SEM4C
Semaphorin-4C

1

1

High-throughput

0.553

High

1445942

RAB18
Ras-related protein Rab-18

1

4

High-throughput

0.553

High

1041715

TNAP2
Tumor necrosis factor alpha-induced protein 2

2

1

High-throughput

0.549

High

1085486

SRBP2
Sterol regulatory element-binding protein 2

2

4

High-throughput

0.549

High

1200295

FAKD1
FAST kinase domain-containing protein 1, mitochondrial

2

2

High-throughput

0.549

High

1230768

HEAT6
HEAT repeat-containing protein 6

2

1

High-throughput

0.549

High

1336552

MROH1
Maestro heat-like repeat-containing protein family member 1

2

1

High-throughput

0.549

High

1450916

RNF12
E3 ubiquitin-protein ligase RLIM

2

2

High-throughput

0.549

High

1490562

BIG1
Brefeldin A-inhibited guanine nucleotide-exchange protein 1

2

7

High-throughput

0.549

High

753853

MRP1
Multidrug resistance-associated protein 1

1

0

High-throughput

0.546

High

341490

CDS2
Phosphatidate cytidylyltransferase 2

1

4

High-throughput

0.536

High

1085404

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

2

High-throughput

0.536

High

1207911

S27A3
Long-chain fatty acid transport protein 3

1

2

High-throughput

0.536

High

1219375

ECM29
Proteasome adapter and scaffold protein ECM29

1

7

High-throughput

0.536

High

1225735

LPCT4
Lysophospholipid acyltransferase LPCAT4

1

3

High-throughput

0.536

High

1228381

GL8D1
Glycosyltransferase 8 domain-containing protein 1

1

1

High-throughput

0.536

High

1280091

FRMD5
FERM domain-containing protein 5

1

7

High-throughput

0.536

High

1317092

CKLF8
CKLF-like MARVEL transmembrane domain-containing protein 8

1

2

High-throughput

0.536

High

1362096

PMGT1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

1

1

High-throughput

0.536

High

1363896

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

7

High-throughput

0.536

High

1365419

LGAT1
Acyl-CoA:lysophosphatidylglycerol acyltransferase 1

1

3

High-throughput

0.536

High

1392700

MYO19
Unconventional myosin-XIX

1

6

High-throughput

0.536

High

1434540

HEAT1
HEAT repeat-containing protein 1

1

2

High-throughput

0.536

High

1437192

L2HDH
L-2-hydroxyglutarate dehydrogenase, mitochondrial

1

2

High-throughput

0.536

High

1141614

OZF
Zinc finger protein OZF

1

0

High-throughput

0.517

High

593623

GDC
Solute carrier family 25 member 16

1

6

High-throughput

0.514

High

937561

CAD11
Cadherin-11

1

5

High-throughput

0.514

High

1102299

ATM
Serine-protein kinase ATM

1

7

High-throughput

0.514

High

1325635

GLT16
Polypeptide N-acetylgalactosaminyltransferase 16

1

3

High-throughput

0.514

High

1331323

S2529
Mitochondrial basic amino acids transporter

1

6

High-throughput

0.514

High

1410960

ODC
Mitochondrial 2-oxodicarboxylate carrier

1

5

High-throughput

0.514

High

1490557

PCDGD
Protocadherin gamma-B1

1

4

High-throughput

0.514

High

1490558

PCDA8
Protocadherin alpha-8

1

4

High-throughput

0.514

High

238642

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.513

High

562822

CY24A
Cytochrome b-245 light chain

1

0

High-throughput

0.513

High

895305

CPT1A
Carnitine O-palmitoyltransferase 1, liver isoform

1

0

High-throughput

0.513

High

1243343

INT5
Integrator complex subunit 5

1

0

High-throughput

0.513

High

1450562

FANCI
Fanconi anemia group I protein

1

0

High-throughput

0.513

High

1451909

CKLF6
CKLF-like MARVEL transmembrane domain-containing protein 6

1

0

High-throughput

0.513

High

1461158

MA1B1
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

1

0

High-throughput

0.513

High

1142735

PDK2
[Pyruvate dehydrogenase

1

1

High-throughput

0.494

High

143948

NDKM
Nucleoside diphosphate kinase, mitochondrial

1

1

High-throughput

0.489

High

178588

PLCB
1-acyl-sn-glycerol-3-phosphate acyltransferase beta

1

4

High-throughput

0.489

High

244034

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

5

High-throughput

0.489

High

318175

IPO13
Importin-13

1

15

High-throughput

0.489

High

557538

SRC
Proto-oncogene tyrosine-protein kinase Src

1

10

High-throughput

0.489

High

658796

JAK1
Tyrosine-protein kinase JAK1

1

18

High-throughput

0.489

High

944430

SYJ2B
Synaptojanin-2-binding protein

1

9

High-throughput

0.489

High

1025865

BORG5
Cdc42 effector protein 1

1

1

High-throughput

0.489

High

1122823

DOCK1
Dedicator of cytokinesis protein 1

1

11

High-throughput

0.489

High

1130225

SMC1A
Structural maintenance of chromosomes protein 1A

1

3

High-throughput

0.489

High

1214831

ATD3B
ATPase family AAA domain-containing protein 3B

1

2

High-throughput

0.489

High

1242107

TTC27
Tetratricopeptide repeat protein 27

1

1

High-throughput

0.489

High

1245154

RHDF2
Inactive rhomboid protein 2

1

2

High-throughput

0.489

High

1273032

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

2

High-throughput

0.489

High

1277543

MON2
Protein MON2 homolog

1

6

High-throughput

0.489

High

1361688

ELYS
Protein ELYS

1

4

High-throughput

0.489

High

1402482

MYADM
Myeloid-associated differentiation marker

1

1

High-throughput

0.489

High

1432330

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

2

High-throughput

0.489

High

1435656

DOCK5
Dedicator of cytokinesis protein 5

1

2

High-throughput

0.489

High

1448436

PYRG2
CTP synthase 2

1

1

High-throughput

0.489

High

1450031

PLCE
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

1

4

High-throughput

0.489

High

1450510

DJC11
DnaJ homolog subfamily C member 11

1

9

High-throughput

0.489

High

361723

F13A
Coagulation factor XIII A chain

1

0

High-throughput

0.481

High

1436440

CNNM2
Metal transporter CNNM2

1

0

High-throughput

0.481

High

72686

UPK3L
Uroplakin-3b-like protein 1

1

0

High-throughput

0.458

High

1047259

ATP7A
Copper-transporting ATPase 1

1

4

High-throughput

0.445

High

1106247

MYO9B
Unconventional myosin-IXb

1

5

High-throughput

0.445

High

1211222

ODR4
Protein odr-4 homolog

1

1

High-throughput

0.445

High

1395065

ELMO2
Engulfment and cell motility protein 2

1

1

High-throughput

0.445

High

1446654

AT132
Polyamine-transporting ATPase 13A2

1

9

High-throughput

0.445

High

1490560

ALG5
Dolichyl-phosphate beta-glucosyltransferase

1

1

High-throughput

0.445

High

136451

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

High-throughput

0.437

High

220041

XRCC3
DNA repair protein XRCC3

1

1

High-throughput

0.437

High

318418

MYO1D
Unconventional myosin-Id

1

4

High-throughput

0.437

High

1364897

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

18

High-throughput

0.437

High

1395595

FACR2
Fatty acyl-CoA reductase 2

1

1

High-throughput

0.437

High

841283

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.426

High

1200414

TM177
Transmembrane protein 177

1

0

High-throughput

0.426

High

1309815

IPRI
Inositol 1,4,5-trisphosphate receptor-interacting protein

1

0

High-throughput

0.426

High

1392195

RUSF1
RUS family member 1

1

0

High-throughput

0.426

High

1405073

SORT
Sortilin

1

0

High-throughput

0.426

High

1416870

TACAN
Transmembrane protein 120A

1

0

High-throughput

0.426

High

1428904

TM39B
Transmembrane protein 39B

1

0

High-throughput

0.426

High

1454475

TM181
Transmembrane protein 181

1

0

High-throughput

0.426

High

208098

TTI1
TELO2-interacting protein 1 homolog

1

2

High-throughput

0.407

High

942513

DHB7
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7

1

2

High-throughput

0.407

High

1122053

EFR3A
Protein EFR3 homolog A

1

2

High-throughput

0.407

High

1159191

SGCB
Beta-sarcoglycan

1

1

High-throughput

0.407

High

1272036

ARMX2
Armadillo repeat-containing X-linked protein 2

1

2

High-throughput

0.407

High

1308017

RELL1
RELT-like protein 1

1

1

High-throughput

0.407

High

1327750

MACOI
Macoilin

1

5

High-throughput

0.407

High

1449028

PLCD
1-acyl-sn-glycerol-3-phosphate acyltransferase delta

1

3

High-throughput

0.407

High

65369

TCAF2
TRPM8 channel-associated factor 2

3

0

High-throughput

0.347

High

342473

RPP29
Ribonuclease P protein subunit p29

3

0

High-throughput

0.347

High

397628

NU1M
NADH-ubiquinone oxidoreductase chain 1

3

0

High-throughput

0.347

High

1198329

TIGD5
Tigger transposable element-derived protein 5

3

0

High-throughput

0.347

High

1310064

DEN6A
Protein DENND6A

3

0

High-throughput

0.347

High

1357814

PTCD2
Pentatricopeptide repeat-containing protein 2, mitochondrial

3

0

High-throughput

0.347

High

1389730

TV23C
Golgi apparatus membrane protein TVP23 homolog C

3

0

High-throughput

0.347

High

1458925

MTFP1
Mitochondrial fission process protein 1

3

0

High-throughput

0.347

High

1005783

RPP38
Ribonuclease P protein subunit p38

2

0

High-throughput

0.318

High

1071230

ABD18
Protein ABHD18

2

0

High-throughput

0.318

High

1379893

FATE1
Fetal and adult testis-expressed transcript protein

2

0

High-throughput

0.316

High

187576

FANCA
Fanconi anemia group A protein

2

0

High-throughput

0.313

High

1260328

INT8
Integrator complex subunit 8

2

0

High-throughput

0.313

High

1252037

TRI72
Tripartite motif-containing protein 72

1

0

Small-scale

0.292

High

177621

MRPP3
Mitochondrial ribonuclease P catalytic subunit

1

0

High-throughput

0.279

Low

317483

GFPT2
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

1

0

High-throughput

0.279

Low

1133246

STAR3
StAR-related lipid transfer protein 3

1

0

High-throughput

0.279

Low

1239158

NEPRO
Nucleolus and neural progenitor protein

1

0

High-throughput

0.279

Low

1286513

SCD5
Stearoyl-CoA desaturase 5

1

0

High-throughput

0.279

Low

1347975

NUBPL
Iron-sulfur cluster transfer protein NUBPL

1

0

High-throughput

0.279

Low

1412365

TIM29
Mitochondrial import inner membrane translocase subunit Tim29

1

0

High-throughput

0.279

Low

1434827

NSUN3
tRNA

1

0

High-throughput

0.279

Low

1449585

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

High-throughput

0.279

Low

1450877

PAPD1
Poly(A) RNA polymerase, mitochondrial

1

0

High-throughput

0.279

Low

1452980

CISD1
CDGSH iron-sulfur domain-containing protein 1

1

0

High-throughput

0.279

Low

1459153

PISD
Phosphatidylserine decarboxylase proenzyme, mitochondrial

1

0

High-throughput

0.279

Low

1490554

NOC2L
Nucleolar complex protein 2 homolog

1

0

High-throughput

0.279

Low

1448771

C42S2
CDC42 small effector protein 2

1

0

High-throughput

0.249

Low

49478

TM223
Transmembrane protein 223

1

0

High-throughput

0.232

Low

49602

GXLT2
Glucoside xylosyltransferase 2

1

0

High-throughput

0.232

Low

183872

VGF
Neurosecretory protein VGF [Cleaved into: Neuroendocrine regulatory peptide-1

1

0

High-throughput

0.232

Low

720554

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

0

High-throughput

0.232

Low

1281032

PIGW
Glucosaminyl-phosphatidylinositol-acyltransferase PIGW

1

0

High-throughput

0.232

Low

1322842

ORML3
ORM1-like protein 3

1

0

High-throughput

0.232

Low

1324962

VW5B2
von Willebrand factor A domain-containing protein 5B2

1

0

High-throughput

0.232

Low

1450858

TM38B
Trimeric intracellular cation channel type B

1

0

High-throughput

0.232

Low

1490564

SQOR
Sulfide:quinone oxidoreductase, mitochondrial

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025