HitPredict

Interactor 1: UBE2K (P61086)
Ubiquitin-conjugating enzyme E2 K (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme K) (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase)
Gene: UBE2K

Interactor 2: DZIP3 (Q86Y13)
E3 ubiquitin-protein ligase DZIP3 (EC 2.3.2.27) (DAZ-interacting protein 3) (RING-type E3 ubiquitin transferase DZIP3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138)
Gene: DZIP3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	19549727
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	GO:0000209 - protein polyubiquitination GO:0004842 - ubiquitin-protein transferase activity GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 200 Hs			1 1208
+	Hs
		1205159 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		DZIP3_HUMAN (1-1208): 0: 1250: 100.00
+	Hs
		849362 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		DZIP3_HUMAN (1-1208): 0: 1250: 100.00
+	Hs
		196282 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		PJA2_HUMAN (601-1207): 1.64e-59: 220: 14.47
+	Hs
		196372 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		PJA2_HUMAN (601-1207): 1.64e-59: 220: 14.47
+	Hs
		196294 UB2D2_HUMAN (4-154): 7.76e-75: 223: 41.06		PJA2_HUMAN (601-1207): 1.64e-59: 220: 14.47
+	Hs
		865028 UB2D2_HUMAN (4-154): 7.76e-75: 223: 41.06		TTC3_HUMAN (703-1207): 1.23e-42: 173: 19.15
+	Hs
		1170316 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		ARK2C_HUMAN (1008-1191): 3.26e-29: 122: 17.74
+	Hs
		849350 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		ARK2C_HUMAN (1008-1191): 3.26e-29: 122: 17.74
+	Hs
		919759 UB2D2_HUMAN (4-154): 7.76e-75: 223: 41.06		ARK2C_HUMAN (1008-1191): 3.26e-29: 122: 17.74
+	Hs
		1148281 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		RNF43_HUMAN (1104-1206): 7.85e-24: 110: 26.79
+	Hs
		849341 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		RNF43_HUMAN (1104-1206): 7.85e-24: 110: 26.79
+	Hs
		919752 UB2D2_HUMAN (4-154): 7.76e-75: 223: 41.06		RNF43_HUMAN (1104-1206): 7.85e-24: 110: 26.79
+	Zm
		39810 B4FCQ9_MAIZE (4-155): 5.41e-75: 224: 40.79		A0A1D6N2L7_MAIZE (1078-1193): 5.69e-25: 106: 21.19
+	Hs
		1356934 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		RN150_HUMAN (1102-1202): 2.69e-22: 103: 21.36
+	Hs
		849485 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		RN150_HUMAN (1102-1202): 2.69e-22: 103: 21.36
+	Hs
		1204871 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		GOLI_HUMAN (1107-1194): 1.08e-21: 101: 23.33
+	Hs
		849359 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		GOLI_HUMAN (1107-1194): 1.08e-21: 101: 23.33
+	Zm
		74334 B4FC97_MAIZE (4-155): 5.47e-75: 224: 42.11		B6U926_MAIZE (1112-1204): 4.67e-22: 101: 26.60
+	Hs
		849382 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		RN128_HUMAN (1112-1206): 2.54e-21: 100: 26.73
+	Hs
		919766 UB2D2_HUMAN (4-154): 7.76e-75: 223: 41.06		SYVN1_HUMAN (1108-1192): 8.82e-15: 80.9: 32.58