Protein: PEX5
Peroxisomal targeting signal 1 receptor (PTS1 receptor) (PTS1R) (PTS1-BP) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1)

Gene: PEX5
Organism: Homo sapiens
Interactions: 194
UniProt ID: P50542

Gene Ontology (top 5):
GO:0000038 - very long-chain fatty acid metabolic process
GO:0000268 - peroxisome targeting sequence binding
GO:0000425 - pexophagy
GO:0001764 - neuron migration
GO:0005052 - peroxisome matrix targeting signal-1 binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

278828

PEX14
Peroxisomal membrane protein PEX14

11

5

Small-scale

0.760

High

450958

LDHB
L-lactate dehydrogenase B chain

1

3

High-throughput

0.740

High

142087

PEX12
Peroxisome assembly protein 12

6

3

Small-scale

0.738

High

142309

PEX7
Peroxisomal targeting signal 2 receptor

5

16

Small-scale

0.718

High

896278

PEX13
Peroxisomal membrane protein PEX13

5

3

Small-scale

0.711

High

896240

ACOX1
Peroxisomal acyl-coenzyme A oxidase 1

4

6

Small-scale

0.671

High

896299

PECR
Peroxisomal trans-2-enoyl-CoA reductase

4

2

Small-scale

0.671

High

399949

CATA
Catalase

4

2

Small-scale

0.670

High

896228

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

4

5

Small-scale

0.670

High

162094

ACOT8
Acyl-coenzyme A thioesterase 8

4

0

Small-scale

0.663

High

253554

PEX10
Peroxisome biogenesis factor 10

3

4

Small-scale

0.646

High

122476

ADAS
Alkyldihydroxyacetonephosphate synthase, peroxisomal

3

1

Small-scale

0.640

High

896283

AP2M1
AP-2 complex subunit mu

3

0

High-throughput

0.638

High

896339

NEUR2
Sialidase-2

3

0

High-throughput

0.638

High

284552

ECI2
Enoyl-CoA delta isomerase 2

3

7

Small-scale

0.631

High

846005

CACP
Carnitine O-acetyltransferase

3

4

Small-scale

0.631

High

896223

DHB4
Peroxisomal multifunctional enzyme type 2

3

6

Small-scale

0.631

High

896266

LONP2
Lon protease homolog 2, peroxisomal

3

4

Small-scale

0.631

High

896298

DHRS4
Dehydrogenase/reductase SDR family member 4

3

1

Small-scale

0.631

High

896314

DECR2
Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]

3

3

Small-scale

0.631

High

896319

TBA8
Tubulin alpha-8 chain

3

7

Small-scale

0.631

High

638838

AGT1
Alanine--glyoxylate aminotransferase

2

1

Small-scale

0.629

High

896230

ATM
Serine-protein kinase ATM

2

1

Small-scale

0.618

High

896237

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

10

High-throughput

0.618

High

896267

MIRO2
Mitochondrial Rho GTPase 2

1

6

High-throughput

0.618

High

479202

THIK
3-ketoacyl-CoA thiolase, peroxisomal

2

2

High-throughput

0.611

High

729180

HNRH1
Heterogeneous nuclear ribonucleoprotein H

2

10

High-throughput

0.606

High

896279

GLMN
Glomulin

2

1

High-throughput

0.606

High

183138

GNPAT
Dihydroxyacetone phosphate acyltransferase

3

0

Small-scale

0.604

High

896329

HACL1
2-hydroxyacyl-CoA lyase 1

3

0

Small-scale

0.604

High

896335

GSTK1
Glutathione S-transferase kappa 1

3

0

Small-scale

0.604

High

896303

IQCN
IQ domain-containing protein N

2

0

High-throughput

0.602

High

231686

PEX1
Peroxisomal ATPase PEX1

2

5

Small-scale

0.595

High

702421

PEX2
Peroxisome biogenesis factor 2

2

1

Small-scale

0.584

High

891382

GSK3B
Glycogen synthase kinase-3 beta

2

6

High-throughput

0.584

High

896246

TYSD1
Peroxisomal leader peptide-processing protease

2

1

Small-scale

0.584

High

896258

HSDL2
Hydroxysteroid dehydrogenase-like protein 2

2

8

Small-scale

0.584

High

896261

ACD11
Acyl-CoA dehydrogenase family member 11

2

1

Small-scale

0.584

High

896308

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

2

0

High-throughput

0.580

High

323240

TRI37
E3 ubiquitin-protein ligase TRIM37

1

12

Small-scale

0.573

High

445148

S10A6
Protein S100-A6

1

2

High-throughput

0.573

High

896252

CAPR2
Caprin-2

1

1

High-throughput

0.573

High

896291

OXDD
D-aspartate oxidase

2

2

Small-scale

0.571

High

896270

PTGR3
Prostaglandin reductase 3

2

0

Small-scale

0.559

High

896285

SCRN2
Secernin-2

2

1

High-throughput

0.553

High

896247

CCD14
Coiled-coil domain-containing protein 14

1

0

High-throughput

0.549

High

896322

PRR13
Proline-rich protein 13

1

0

High-throughput

0.549

High

896264

NUFP2
FMR1-interacting protein NUFIP2

1

1

High-throughput

0.541

High

896313

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

1

1

High-throughput

0.541

High

896336

FIS1
Mitochondrial fission 1 protein

2

0

Small-scale

0.539

High

66927

AQ12B
Putative aquaporin-12B

1

1

High-throughput

0.536

High

341913

CEP43
Centrosomal protein 43

1

1

High-throughput

0.536

High

718783

CCND2
G1/S-specific cyclin-D2

1

6

High-throughput

0.536

High

772678

MYH9
Myosin-9

1

2

High-throughput

0.536

High

896239

MD2BP
MAD2L1-binding protein

1

1

High-throughput

0.536

High

896244

STK11
Serine/threonine-protein kinase STK11

1

1

High-throughput

0.536

High

896286

CREL1
Protein disulfide isomerase CRELD1

1

4

High-throughput

0.536

High

896300

DUS16
Dual specificity protein phosphatase 16

1

2

High-throughput

0.536

High

896340

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

2

High-throughput

0.536

High

896231

SQSTM
Sequestosome-1

1

4

Small-scale

0.534

High

896254

ACD10
Acyl-CoA dehydrogenase family member 10

1

2

Small-scale

0.527

High

896251

ZN772
Zinc finger protein 772

1

1

High-throughput

0.523

High

326817

SPN1
Snurportin-1

1

0

High-throughput

0.518

High

896241

PLEC
Plectin

1

1

High-throughput

0.515

High

896271

Q8N5N8
TM6SF1 protein

1

1

High-throughput

0.515

High

165762

PAHX
Phytanoyl-CoA dioxygenase, peroxisomal

1

0

High-throughput

0.513

High

261479

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.513

High

724008

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.513

High

834281

GARS
Glycine--tRNA ligase

1

0

High-throughput

0.513

High

892972

ENTP1
Ectonucleoside triphosphate diphosphohydrolase 1

1

0

High-throughput

0.513

High

896225

CACB3
Voltage-dependent L-type calcium channel subunit beta-3

1

0

High-throughput

0.513

High

896256

TM154
Transmembrane protein 154

1

0

High-throughput

0.513

High

896274

SYTL5
Synaptotagmin-like protein 5

1

0

High-throughput

0.513

High

896306

CSTP1
Centriolar satellite-associated tubulin polyglutamylase complex regulator 1

1

0

High-throughput

0.513

High

896338

FBX7
F-box only protein 7

1

0

High-throughput

0.513

High

288373

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

2

Small-scale

0.501

High

896234

PEX6
Peroxisomal ATPase PEX6

1

5

Small-scale

0.501

High

896280

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

6

Small-scale

0.501

High

724975

HXA7
Homeobox protein Hox-A7

1

3

High-throughput

0.494

High

896248

NHRF3
Na(+)/H(+) exchange regulatory cofactor NHE-RF3

1

6

High-throughput

0.494

High

252753

AP180
Clathrin coat assembly protein AP180

1

6

High-throughput

0.489

High

254886

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

6

High-throughput

0.489

High

335313

M3K6
Mitogen-activated protein kinase kinase kinase 6

1

9

High-throughput

0.489

High

376598

TGFA
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha

1

2

High-throughput

0.489

High

848601

MAGA9
Melanoma-associated antigen 9

1

1

High-throughput

0.489

High

896238

HLX
H2.0-like homeobox protein

1

9

High-throughput

0.489

High

896268

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

3

High-throughput

0.489

High

896284

ERLEC
Endoplasmic reticulum lectin 1

1

1

High-throughput

0.489

High

896288

RN145
RING finger protein 145

1

2

High-throughput

0.489

High

896294

NPAS1
Neuronal PAS domain-containing protein 1

1

2

High-throughput

0.489

High

896309

C1QR1
Complement component C1q receptor

1

1

High-throughput

0.489

High

352697

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

0

High-throughput

0.486

High

798854

BRCA1
Breast cancer type 1 susceptibility protein

1

8

High-throughput

0.481

High

896222

RL14
Large ribosomal subunit protein eL14

1

2

High-throughput

0.481

High

896324

TOM7
Mitochondrial import receptor subunit TOM7 homolog

1

1

High-throughput

0.481

High

896263

PEX26
Peroxisome assembly protein 26

1

0

Small-scale

0.480

High

61458

VWA8
von Willebrand factor A domain-containing protein 8

1

1

High-throughput

0.479

High

172588

XPO1
Exportin-1

1

11

High-throughput

0.479

High

180752

TIF1A
Transcription intermediary factor 1-alpha

1

18

Small-scale

0.479

High

437124

K2C8
Keratin, type II cytoskeletal 8

1

5

High-throughput

0.479

High

588219

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

611037

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

2

High-throughput

0.479

High

674968

TNR6
Tumor necrosis factor receptor superfamily member 6

1

1

High-throughput

0.479

High

878415

PAXI
Paxillin

1

1

High-throughput

0.479

High

891075

GSK3A
Glycogen synthase kinase-3 alpha

1

6

High-throughput

0.479

High

896227

AP2B1
AP-2 complex subunit beta

1

3

High-throughput

0.479

High

896233

DCTN2
Dynactin subunit 2

1

1

High-throughput

0.479

High

896235

CUL3
Cullin-3

1

7

High-throughput

0.479

High

896242

KS6A2
Ribosomal protein S6 kinase alpha-2

1

3

High-throughput

0.479

High

896243

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

1

High-throughput

0.479

High

896249

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

1

High-throughput

0.479

High

896250

A16L1
Autophagy-related protein 16-1

1

13

High-throughput

0.479

High

896259

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.479

High

896265

MAVS
Mitochondrial antiviral-signaling protein

1

7

High-throughput

0.479

High

896276

CNOT9
CCR4-NOT transcription complex subunit 9

1

1

High-throughput

0.479

High

896277

GOGA1
Golgin subfamily A member 1

1

3

High-throughput

0.479

High

896289

RMD3
Regulator of microtubule dynamics protein 3

1

1

High-throughput

0.479

High

896292

NECD
Necdin

1

1

High-throughput

0.479

High

896304

CCDC8
Coiled-coil domain-containing protein 8

1

1

High-throughput

0.479

High

896310

PXMP2
Peroxisomal membrane protein 2

1

2

High-throughput

0.479

High

896323

MTCH1
Mitochondrial carrier homolog 1

1

3

High-throughput

0.479

High

896327

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

896330

HOOK1
Protein Hook homolog 1

1

3

High-throughput

0.479

High

896341

MTCH2
Mitochondrial carrier homolog 2

1

4

High-throughput

0.479

High

69587

A8K3Q9
Large ribosomal subunit protein eL14

1

2

High-throughput

0.470

High

896253

Q6IPH7
Large ribosomal subunit protein eL14

1

2

High-throughput

0.470

High

896255

Q6NSB6
MKRN3 protein

1

1

High-throughput

0.470

High

896262

Q75MR5
Mitochondrial import receptor subunit TOM7 homolog

1

1

High-throughput

0.470

High

770718

SSR5
Somatostatin receptor type 5

1

1

Small-scale

0.462

High

166888

MGST3
Glutathione S-transferase 3, mitochondrial

1

0

High-throughput

0.458

High

783136

ARL3
ADP-ribosylation factor-like protein 3

1

0

High-throughput

0.458

High

896221

VASP
Vasodilator-stimulated phosphoprotein

1

0

High-throughput

0.458

High

896226

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.458

High

896287

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.458

High

896305

VP33B
Vacuolar protein sorting-associated protein 33B

1

0

High-throughput

0.458

High

896311

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.458

High

896316

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

896317

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.458

High

896318

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

High-throughput

0.458

High

896337

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

0

High-throughput

0.458

High

896232

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

7

High-throughput

0.445

High

896302

ZDHC5
Palmitoyltransferase ZDHHC5

1

4

High-throughput

0.445

High

896326

SL9A2
Sodium/hydrogen exchanger 2

1

1

High-throughput

0.445

High

896229

MKRN3
E3 ubiquitin-protein ligase makorin-3

1

1

High-throughput

0.439

High

896301

TM6S1
Transmembrane 6 superfamily member 1

1

1

High-throughput

0.439

High

896333

ANR50
Ankyrin repeat domain-containing protein 50

1

4

High-throughput

0.439

High

694946

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

767714

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

896334

TRI33
E3 ubiquitin-protein ligase TRIM33

1

7

High-throughput

0.437

High

896224

MOT1
Monocarboxylate transporter 1

1

0

High-throughput

0.426

High

3597

A0A0S2Z6F4
Ankyrin repeat domain 50 isoform 2

1

5

High-throughput

0.417

High

71716

NUD19
Acyl-coenzyme A diphosphatase NUDT19

1

1

Small-scale

0.408

High

171416

S27A2
Long-chain fatty acid transport protein 2

1

5

Small-scale

0.408

High

184056

ACOX3
Peroxisomal acyl-coenzyme A oxidase 3

1

6

Small-scale

0.408

High

296041

IDHC
Isocitrate dehydrogenase [NADP] cytoplasmic

1

1

Small-scale

0.408

High

575125

IDE
Insulin-degrading enzyme

1

3

Small-scale

0.408

High

577387

OXDA
D-amino-acid oxidase

1

2

Small-scale

0.408

High

647427

SCP2
Sterol carrier protein 2

1

8

Small-scale

0.408

High

761176

HYES
Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2

1

2

Small-scale

0.408

High

777601

HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial

1

2

Small-scale

0.408

High

811737

MPV17
Mitochondrial inner membrane protein Mpv17

1

2

Small-scale

0.408

High

888689

ACOT2
Acyl-coenzyme A thioesterase 2, mitochondrial

1

2

Small-scale

0.408

High

896236

BAAT
Bile acid-CoA:amino acid N-acyltransferase

1

2

Small-scale

0.408

High

896257

PAOX
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase

1

3

Small-scale

0.408

High

896272

ACOT4
Peroxisomal succinyl-coenzyme A thioesterase

1

2

Small-scale

0.408

High

896290

ACOX2
Peroxisomal acyl-coenzyme A oxidase 2

1

6

Small-scale

0.408

High

896320

HAOX2
2-Hydroxyacid oxidase 2

1

3

Small-scale

0.408

High

896331

HAOX1
2-Hydroxyacid oxidase 1

1

3

Small-scale

0.408

High

896332

OCTC
Peroxisomal carnitine O-octanoyltransferase

1

4

Small-scale

0.408

High

516896

ECE2
Endothelin-converting enzyme 2

1

2

High-throughput

0.407

High

896269

SLX4
Structure-specific endonuclease subunit SLX4

1

8

High-throughput

0.407

High

896312

CAH10
Carbonic anhydrase-related protein 10

1

1

High-throughput

0.407

High

348242

DCMC
Malonyl-CoA decarboxylase, mitochondrial

1

0

Small-scale

0.391

High

501690

NUDT7
Peroxisomal coenzyme A diphosphatase NUDT7

1

0

Small-scale

0.391

High

716411

PRDX5
Peroxiredoxin-5, mitochondrial

1

0

Small-scale

0.391

High

766151

NOS2
Nitric oxide synthase, inducible

1

0

Small-scale

0.391

High

896325

SOX
Peroxisomal sarcosine oxidase

1

0

Small-scale

0.391

High

896328

AMACR
Alpha-methylacyl-CoA racemase

1

0

Small-scale

0.391

High

458677

SAP
Prosaposin

2

0

High-throughput

0.316

High

896307

ZFAN3
AN1-type zinc finger protein 3

2

0

High-throughput

0.316

High

896297

TINF2
TERF1-interacting nuclear factor 2

1

0

High-throughput

0.299

High

896275

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

1

0

High-throughput

0.299

High

896281

ACD
Adrenocortical dysplasia protein homolog

1

0

High-throughput

0.288

High

896315

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.288

High

260715

RAMP1
Receptor activity-modifying protein 1

1

0

High-throughput

0.279

Low

378424

IFNG
Interferon gamma

1

0

High-throughput

0.279

Low

896245

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.279

Low

896260

K0408
Uncharacterized protein KIAA0408

1

0

High-throughput

0.279

Low

896273

TLC3A
TLC domain-containing protein 3A

1

0

High-throughput

0.279

Low

896282

FAM3D
Protein FAM3D

1

0

High-throughput

0.279

Low

896293

CGRE1
Cell growth regulator with EF hand domain protein 1

1

0

High-throughput

0.279

Low

896295

SSX3
Protein SSX3

1

0

High-throughput

0.279

Low

896296

KXDL1
KxDL motif-containing protein 1

1

0

High-throughput

0.279

Low

896321

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025