HitPredict

Interactor 1: UBE2K (P61086)
Ubiquitin-conjugating enzyme E2 K (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme K) (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase)
Gene: UBE2K

Interactor 2: TRAIP (Q9BWF2)
E3 ubiquitin-protein ligase TRAIP (EC 2.3.2.27) (RING finger protein 206) (TRAF-interacting protein)
Gene: TRAIP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	19549727, 32814053
Identification Methods	two hybrid, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 200 Hs			1 469
+	Hs
		849430 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		TRAIP_HUMAN (1-469): 1.32e-114: 346: 100.00
+	Hs
		919842 UB2D2_HUMAN (4-154): 7.76e-75: 223: 41.06		TRAIP_HUMAN (1-469): 1.32e-114: 346: 100.00
+	Hs
		895896 UB2D3_HUMAN (4-154): 1.49e-73: 220: 39.74		TRAIP_HUMAN (1-469): 1.32e-114: 346: 100.00
+	Hs
		72157 B3KSH4_HUMAN (104-200): 1.63e-61: 187: 100.00		TRAIP_HUMAN (1-469): 1.32e-114: 346: 100.00
+	Hs
		787873 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		EPS15_HUMAN (3-170): 2.69e-10: 64.9: 14.53
+	Hs
		787888 UB2D2_HUMAN (4-154): 7.76e-75: 223: 41.06		EPS15_HUMAN (3-170): 2.69e-10: 64.9: 14.53
+	Hs
		787884 UB2D3_HUMAN (4-154): 1.49e-73: 220: 39.74		EPS15_HUMAN (3-170): 2.69e-10: 64.9: 14.53
+	Hs
		787874 UB2E1_HUMAN (3-153): 1.87e-66: 203: 39.74		EPS15_HUMAN (3-170): 2.69e-10: 64.9: 14.53
+	Dm
		715093 UBE2N_DROME (43-153): 2.22e-34: 120: 53.15		Q7K2X1_DROME (7-294): 2.71e-30: 123: 23.65